Search Results - biofilm

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Control of Periprosthetic Joint Infections (Case No. 2021-334)
Summary: UCLA researchers in the Department of Orthopaedic Surgery have developed a non-invasive method to disrupt biofilms on orthopaedic implants and decrease the overall rate of infections. Background: Prosthetic joint infection (PJI) remains a serious complication in hip and knee arthroplasty, with skyrocketing revision rates across all orthopaedic...
Published: 9/23/2024   |   Inventor(s): Fabrizio Billi, Beth Lazazzera
Keywords(s): Biofilm, Cell Growth, electromagnetic, Infection, Nanoparticle, Orthopaedics, Orthopedics and Prosthetics (O & P), Osteo, Prosthetics
Category(s): Medical Devices > Prosthetics, Chemical > Coatings, Adhesives & Inks, Diagnostic Markers > Immunology, Materials > Membranes, Medical Devices > Coatings, Therapeutics > Orthopaedics
A Human Monoclonal Antibody Against Deacetylated PNAG for Use as an Antimicrobial Agent
Abstract: Biofilms are complex microbial communities, surface attached and held together by self-produced polymer matrices.  These matrices are mainly composed of polysaccharides, secreted proteins and nucleic acids.  Poly-N-acetyl glucosamine (PNAG) is a highly conserved surface polysaccharide expressed by a range of bacterial, fungal and protozoan...
Published: 5/22/2024   |   Inventor(s): Jeffrey Gildersleeve, Joel Temme
Keywords(s): ANTIMICROBIAL, Biofilm, Deacetyleated Poly-N-Acetyl Glucosamine, dPNAG, Gildersleeve, Mab, Monoclonal Antibody, TG10
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing
2022-067 Multiwell Plate-Based Flow Culture for Improving the Quality of 3D Tissues
Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a simple, innovative method for growing 3D cell cultures with improved organoid differentiation and reduced hypoxia-induced cell death. TITLE: Multiwell Plate-Based Flow Culture for Improving the Quality of 3D Tissues Background: 3D tissue culture,...
Published: 4/5/2024   |   Inventor(s): Neil Lin, Marie Payne
Keywords(s): 3D Printing, Biofilm, Biomaterial 3D Printing, Biomedical Engineering, Cancer, cancer detection, Cancer Immunotherapy, Cell and tissue culture, Cell Culture, Cellular agriculture, Cultured meat, iPS/stem cells, Laminar flow, Microwell plates, organogenesis, Organoids, Personalized Pharmacotherapy, Pharmaceutical testing, Stem Cells / Regenerative Medicine, Tissue (Biology), tissue detection, Tissue Engineering, Tissue sedimentation
Category(s): Life Science Research Tools > Lab Equipment, Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Therapeutics, Therapeutics > Oncology
Novel Cationic Amphiphiles Control Biofilm Formation for Bacterial Vaginosis
Cationic amphiphiles greatly inhibits the biofilm formation of the pathogenic bacteria in BV. Cationic Amphiphile Concentration (μM) Invention Summary: Bacterial vaginosis (BV) is a common polymicrobial infection in women of reproductive age, affecting 10-30% of women in developed nations. BV can lead to serious complications such as abortion,...
Published: 4/17/2024   |   Inventor(s): Kathryn Uhrich, Allison Faig
Keywords(s): Antibacterial, Biofilm, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
2022-005-METAL PARTICLE/GRAPHENE EXTRACELLUAR MATRIX FOR ENHANCED CHARGE TRANSFER EFFICIENCY IN MICROBIAL FUEL CELLS
SUMMARY: UCLA researchers in the Department of Materials Science and Engineering have developed a method that boosts the electron extraction efficiency and enables high-performance microbial fuel cells (MFCs) with record-high power output. BACKGROUND:: Fuel cells have garnered increased attention as a means of obtaining green energy. They are capable...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s): Biofilm, Electron, Fuel Cell, Materials, Microbiology, Nanomaterials, Nanoparticles, Power Transmission
Category(s): Materials, Materials > Membranes, Materials > Metals, Materials > Nanotechnology, Chemical, Energy & Environment > Energy Generation > Biofuels
Hollow-Fiber Membrane Biofilm Reactor for Denitrification of Drinking Water
NU 1999-063 INVENTORBruce Rittmann*SHORT DESCRIPTIONPrototypes of an autohydrogenotrophic hollow-fiber membrane-biofilm reactor to reduce nitrate and perchlorate pollutants in waterBACKGROUNDMany of the emerging water contaminants share a common characteristic: they are chemically oxidized. The classic examples are nitrate (NO3-) and nitrite (NO2-),...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biofilm, Environment
Category(s): Physical Sciences > Energy & Sustainability
An In-Line UV Disinfection System
NU 2009-001InventorsWei ZhangAaron Packman*Tadas SileikaShort DescriptionA self-enclosed UV disinfection unit that includes a series of capillary tubes in a reflective housing with a UV sourceAbstractThe UV disinfection unit is positioned in-line with inflow/outflow tubing of a circulating flow system, so as to provide flow-through disinfection without...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biofilm, Health & Safety, Instrumentation, Materials, Medical device
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Anti-Biofilm Compound 1 (ABC-1) and Associated Derivative Molecules
IntroductionBacteria commonly attach to living and nonliving surfaces in the form of biofilms. In this morphology, the bacteria synthesize a matrix of extracellular polymeric substances (EPS) that provide the biofilm with protection and structural support. The EPS also gives the biofilm resistance to antibiotics and immune system clearance, making biofilms...
Published: 11/21/2023   |   Inventor(s): Christopher Waters, Karthik Sambanthamoorthy, Matthew Neiditch, Martin Semmelhack
Keywords(s): Biofilm, Film, Pathogen
Category(s): Biotechnology