Search Results - biofilm

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Control of Periprosthetic Joint Infections (Case No. 2021-334)
Summary: UCLA researchers in the Department of Orthopaedic Surgery have developed a non-invasive method to disrupt biofilms on orthopaedic implants and decrease the overall rate of infections. Background: Prosthetic joint infection (PJI) remains a serious complication in hip and knee arthroplasty, with skyrocketing revision rates across all orthopaedic...
Published: 9/23/2024   |   Inventor(s): Fabrizio Billi, Beth Lazazzera
Keywords(s): Biofilm, Cell Growth, electromagnetic, Infection, Nanoparticle, Orthopaedics, Orthopedics and Prosthetics (O & P), Osteo, Prosthetics
Category(s): Medical Devices > Prosthetics, Chemical > Coatings, Adhesives & Inks, Diagnostic Markers > Immunology, Materials > Membranes, Medical Devices > Coatings, Therapeutics > Orthopaedics
A Human Monoclonal Antibody Against Deacetylated PNAG for Use as an Antimicrobial Agent
Abstract: Biofilms are complex microbial communities, surface attached and held together by self-produced polymer matrices.  These matrices are mainly composed of polysaccharides, secreted proteins and nucleic acids.  Poly-N-acetyl glucosamine (PNAG) is a highly conserved surface polysaccharide expressed by a range of bacterial, fungal and protozoan...
Published: 12/17/2024   |   Inventor(s): Jeffrey Gildersleeve, Joel Temme
Keywords(s): ANTIMICROBIAL, Biofilm, Deacetyleated Poly-N-Acetyl Glucosamine, dPNAG, Gildersleeve, Mab, Monoclonal Antibody, TG10
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing
Multiwell Plate-Based Flow Culture for Improving the Quality of 3D Tissues (Case No. 2022-067)
Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a simple, innovative method for growing 3D cell cultures with improved organoid differentiation and reduced hypoxia-induced cell death. TITLE: Multiwell Plate-Based Flow Culture for Improving the Quality of 3D Tissues Background: 3D tissue culture,...
Published: 10/23/2024   |   Inventor(s): Neil Lin, Marie Payne
Keywords(s): 3D Printing, Biofilm, Biomaterial 3D Printing, Biomedical Engineering, Cancer, cancer detection, Cancer Immunotherapy, Cell and tissue culture, Cell Culture, Cellular agriculture, Cultured meat, iPS/stem cells, Laminar flow, Microwell plates, organogenesis, Organoids, Personalized Pharmacotherapy, Pharmaceutical testing, Stem Cells / Regenerative Medicine, Tissue (Biology), tissue detection, Tissue Engineering, Tissue sedimentation
Category(s): Life Science Research Tools > Lab Equipment, Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Therapeutics, Therapeutics > Oncology
Novel Cationic Amphiphiles Control Biofilm Formation for Bacterial Vaginosis
Cationic amphiphiles greatly inhibits the biofilm formation of the pathogenic bacteria in BV. Cationic Amphiphile Concentration (μM) Invention Summary: Bacterial vaginosis (BV) is a common polymicrobial infection in women of reproductive age, affecting 10-30% of women in developed nations. BV can lead to serious complications such as abortion,...
Published: 11/1/2024   |   Inventor(s): Kathryn Uhrich, Allison Faig
Keywords(s): Antibacterial, Biofilm, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
2022-005-METAL PARTICLE/GRAPHENE EXTRACELLUAR MATRIX FOR ENHANCED CHARGE TRANSFER EFFICIENCY IN MICROBIAL FUEL CELLS
SUMMARY: UCLA researchers in the Department of Materials Science and Engineering have developed a method that boosts the electron extraction efficiency and enables high-performance microbial fuel cells (MFCs) with record-high power output. BACKGROUND:: Fuel cells have garnered increased attention as a means of obtaining green energy. They are capable...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s): Biofilm, Electron, Fuel Cell, Materials, Microbiology, Nanomaterials, Nanoparticles, Power Transmission
Category(s): Materials, Materials > Membranes, Materials > Metals, Materials > Nanotechnology, Chemical, Energy & Environment > Energy Generation > Biofuels
Hollow-Fiber Membrane Biofilm Reactor for Denitrification of Drinking Water
NU 1999-063 INVENTORBruce Rittmann*SHORT DESCRIPTIONPrototypes of an autohydrogenotrophic hollow-fiber membrane-biofilm reactor to reduce nitrate and perchlorate pollutants in waterBACKGROUNDMany of the emerging water contaminants share a common characteristic: they are chemically oxidized. The classic examples are nitrate (NO3-) and nitrite (NO2-),...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biofilm, Environment
Category(s): Physical Sciences > Energy & Sustainability
An In-Line UV Disinfection System
NU 2009-001InventorsWei ZhangAaron Packman*Tadas SileikaShort DescriptionA self-enclosed UV disinfection unit that includes a series of capillary tubes in a reflective housing with a UV sourceAbstractThe UV disinfection unit is positioned in-line with inflow/outflow tubing of a circulating flow system, so as to provide flow-through disinfection without...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biofilm, Health & Safety, Instrumentation, Materials, Medical device
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Anti-Biofilm Compound 1 (ABC-1) and Associated Derivative Molecules
Introduction Bacteria commonly attach to living and nonliving surfaces in the form of biofilms. In this morphology, the bacteria synthesize a matrix of extracellular polymeric substances (EPS) that provide the biofilm with protection and structural support. The EPS also gives the biofilm resistance to antibiotics and immune system clearance, making...
Published: 10/1/2024   |   Inventor(s): Christopher Waters, Karthik Sambanthamoorthy, Matthew Neiditch, Martin Semmelhack
Keywords(s): Biofilm, Film, Pathogen
Category(s): Biotechnology