Search Results - venkatareddy+sabbasani

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A New Molecular Scaffold for Targeting hRpn13 as a Treatment for Cancer
This technology includes a new chemical scaffold (with lead compound XL5) against hRpn13 that induces apoptosis, which may have clinical efficacy against cancer. The structure of XL5-conjugated hRpn13 guided the design of XL5-PROTAC degrader compounds that exhibit greater efficacy than previous hRpn13-targeting compounds, as evaluated by selectivity...
Published: 8/12/2024   |   Inventor(s): Venkatareddy Sabbasani, Kylie Walters, Xiuxiu Lu, Nadya Tarasova, Rolf Swenson
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology
PIM-Targeted PROTACs
Abstract: Proviral Integration for the Moloney murine leukemia virus (PIM) kinases are overexpressed in many solid cancers – including prostate, breast, colon, endometrial, gastric and pancreatic. High of PIM1 expression is predictive of poor survival in multiple cancer types. While several selective pan-PIM inhibitors were developed and tested in clinical...
Published: 4/8/2024   |   Inventor(s): John Brognard, Rolf Swenson, Pedro Torres-Ayuso, Venkatareddy Sabbasani, Dawid Mehlich, Noel Warfel
Keywords(s): anti-cancer, Brognard, Chemotherapy Resistance, Kinase, PIM, PIM kinase-targeting proteolysis-targeting chimeras, PROTACs, solid tumors, Swenson, THERAPY
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Calcium/Calmodulin-Regulated Plant Immunity
Unmet Need: Understanding the mechanism of regulation of salicylic acid by Ca2+ signaling Intracellular calcium transients during plant-pathogen interactions are necessary early events leading to local and systemic acquired resistance. Salicylic acid, a critical messenger, is also required for both these responses, but whether and how salicylic acid...
Published: 10/8/2024   |   Inventor(s): B Poovaiah, A Reddy, Gul Ali, Tianbao Yang, Kayla Simons, Jingguo Hou, Liqun Du
Keywords(s): Agriculture and Plant Sciences, Biotechnology
Category(s): Technologies > Food & Nutrition > Agriculture and Plant Sciences, Technologies > Health & Well-being > Biotechnology