Search Results - noel+warfel

2 Results Sort By:
PIM-Targeted PROTACs
Abstract: Proviral Integration for the Moloney murine leukemia virus (PIM) kinases are overexpressed in many solid cancers – including prostate, breast, colon, endometrial, gastric and pancreatic. High of PIM1 expression is predictive of poor survival in multiple cancer types. While several selective pan-PIM inhibitors were developed and tested in clinical...
Published: 4/8/2024   |   Inventor(s): John Brognard, Rolf Swenson, Pedro Torres-Ayuso, Venkatareddy Sabbasani, Dawid Mehlich, Noel Warfel
Keywords(s): anti-cancer, Brognard, Chemotherapy Resistance, Kinase, PIM, PIM kinase-targeting proteolysis-targeting chimeras, PROTACs, solid tumors, Swenson, THERAPY
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Novel Phosphorylation that Controls the Stability of Hypoxia-Inducible Factor 1 Alpha
This invention relates to a polyclonal antibody against a novel phosphorylation site that is known to be correlated with increased tumor growth. Specifically, the antibody targets a phosphorylation site on HIF-1α, which is controlled by PIM kinases. This invention can be used not only as a therapeutic against cancer but also potentially as a means...
Published: 9/5/2024   |   Inventor(s): Noel Warfel
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic