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16950
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ID
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Quinoline-derived SARS-
C
oV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead
c
ompound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Prakash Jadhav
,
Bin Tan
,
Haozhou Tan
Keywords(s):
Antiviral
Category(s):
Te
c
hnology Classifications > COVID-19
,
Te
c
hnology Classifications > Healthcare & Life Sciences
,
Te
c
hnology Classifications > Infectious Disease
,
Te
c
hnology Classifications > Therapeutics
Spe
c
ific inhibitors to mitigate mu opioid‐induced side‐effects without compromising analgesia
Preliminary data shows that the inhibitor signifi
c
antly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 7/31/2025
|
Inventor(s):
Yingxian Pan
Keywords(s):
Category(s):
Te
c
hnology Classifications > Healthcare & Life Sciences
,
Te
c
hnology Classifications
,
Te
c
hnology Classifications > Therapeutics
Method for Optimizing an Integrated Flight
C
ontrol System using Reinforcement Meta-Learning
This te
c
hnology is a method to incorporate reinforcement meta-learning to the design of a flight control system for missiles. The integration will benefit the control system, as it optimizes it with the help of a simulation environment. The technology removes the need for manual tuning of the control system settings. Background: The flight control...
Published: 7/30/2025
|
Inventor(s):
Roberto Furfaro
,
Brian Gaudet
Keywords(s):
Category(s):
Te
c
hnology Classifications > Software & Information Technology
,
Te
c
hnology Classifications > Engineering & Physical Sciences > Aerospace Engineering
TRP: A Mouse Model of Limb Girdle Mus
c
ular Dystrophy Type 2A (R1/D4) (UCLA Case No. 2021-171)
U
C
LA researchers in the Department of Neurology have developed a novel mouse model for limb girdle muscular dystrophy, a disorder that causes muscle weakness in the limbs and hip area. BACKGROUND: Limb-Girdle Muscular Dystrophy Type 2A (LGMDR1) is a genetic neuromuscular disorder characterized by progressive muscle weakness, primarily affecting muscles...
Published: 7/30/2025
|
Inventor(s):
Melissa Spen
c
er
Keywords(s):
Category(s):
Life S
c
ience Research Tools > Animal Models
Regiosele
c
tive 1,2-Dearomatization of Functionalized Azines by Organolanthanide Catalysts
NU2014-129 INVENTORS Tobin Marks* Alexander Dudnik Massimiliano Delferro Vi
c
toria Weidner SHORT DESCRIPTION This invention describes a catalytic process for the regioselective 1,2-dearomatization of functionalized azines using an organolanthanide catalyst and pinacolborane (HBpin). It offers a streamlined approach to key intermediates for pharmaceuticals...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
C
atalyst
,
C
hemicals
,
Manufa
c
turing/Processing
,
Materials
Category(s):
Physi
c
al Sciences > Materials and Industrial Processes
Novel self-healing
c
ommodity copolymers based on 2-ethylhexyl acrylate
NU2023-240 INVENTORS John Torkelson* Tong Wang SHORT DES
C
RIPTION This invention describes a new class of random copolymers that exhibit autonomous self-healing behavior at room temperature. The copolymers, derived entirely from commodity comonomers including 2-ethylhexyl acrylate, fully recover their material properties after damage. BACKGROUND The...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Materials
,
Polymer
,
Smart/Fun
c
tional materials
Category(s):
Physi
c
al Sciences > Materials and Industrial Processes
Multi-Parti
c
le System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: U
C
LA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025
|
Inventor(s):
Dino Di
C
arlo
,
Alyssa Arnheim
,
Mi
c
hael Mellody
,
Yuta Nakagawa
,
Lily Shang
Keywords(s):
Assay
,
B
C
ell
,
bar
c
ode
,
Bioassay
,
biologi
c
al assays
,
Biomarker
,
biomarkers
,
Biomaterial
,
c
apping particles
,
C
AR-T cell platform
,
C
AR-T cell therapy
,
c
avities
,
c
avity-containing particles
,
C
ell and tissue culture
,
c
ell encapsulation
,
c
ell engineering
,
c
ell imaging
,
c
ell mapping
,
c
ell sorting
,
c
ell type identification
,
c
ell-based therapy
,
c
entrifugation
,
c
onfinement
,
Diagnosti
c
Platform Technologies (E.G. Microfluidics)
,
Digital Mi
c
rofluidics
,
Drug
,
Drug Delivery
,
Drug Dis
c
overy
,
drug s
c
reening
,
high throughput
,
high throughput assays
,
high throughput testing
,
high-throughput analysis
,
High-Throughput S
c
reening
,
Immunoassay
,
Immunoassay Sense (Mole
c
ular Biology)
,
Mi
c
rofluidics
,
Mi
c
rofluidics And Mem's
,
Mi
c
rofluidics Nanosphere
,
mi
c
roparticles
,
moieties
,
Nanoparti
c
le
,
single
c
ell analysis
,
single
c
ell analysis and testing
,
Single
c
ell data
,
single-
c
ell resolution
,
single-
c
ell trapping
Category(s):
Life S
c
ience Research Tools
,
Life S
c
ience Research Tools > Cell Counting And Imaging
,
Life S
c
ience Research Tools > Lab Equipment
,
Life S
c
ience Research Tools > Microscopy And Imaging
,
Life S
c
ience Research Tools > Microfluidics And Mems
,
Medi
c
al Devices
,
Platforms
C
ovalent Adaptable Networks with Associative Siloxane Exchange Enabled by Amide-Based Internal Catalysis
NU2025-056 INVENTORS John Torkelson* Tapas Debsharma Nathan Purwanto Tong Wang SHORT DES
C
RIPTION A technology that introduces internally catalyzed siloxane dynamic chemistry in covalent adaptable networks (CANs) through amide-based catalysis to produce recyclable and reprocessable polymers with maintained cross-link density at elevated temperatures. BACKGROUND Replacing...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physi
c
al Sciences > Materials and Industrial Processes
Re
c
yclable and Depolymerizable Polymer Network Materials via Thiourethane Dynamic Chemistry
NU2019-126 INVENTORS John Torkelson* Lingqiao Li Xi
C
hen SHORT DESCRIPTION A class of reprocessable, PU-like polymer networks synthesized via thiourethane dynamic chemistry that allow for complete cross-link density recovery and offer the potential for monomer recovery under mild conditions. BACKGROUND Traditional cross-linked polyurethane...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physi
c
al Sciences > Materials and Industrial Processes
Fusion Protein for Development of Transgeni
c
Resistance to Lepidopteran Pests
A Spe
c
ific, Eco-Friendly Approach to Pest Control Using Genetically Engineered Biopesticides A fusion protein comprised of a densovirus coat protein, a proline-rich linker, and an insect-specific neurotoxin allows for the development of transgenic crops with resistance to lepidopteran (caterpillar) pests. Insects cause agricultural loss and economic...
Published: 7/31/2025
|
Inventor(s):
Bryony Bonning
Keywords(s):
Category(s):
Te
c
hnology Classifications > Agricultural > Insect Control
,
Te
c
hnology Classifications > Agricultural > Therapeutics
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