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Novel Method to Treat Heart Disease in Duchenne Muscular Dystrophy (DMD) Patients

Advantages: Novel Therapeutic target to treat cardiac dystrophy in DMD: Nox4 Inhibition Potential to reduce fibrosis and improve cardiac function over conventional treatments Potential to combine NOX4 inhibition with dystrophin replacement therapies Summary: Duchenne Muscular Dystrophy (DMD) is a genetic disorder caused by mutations in the...

Published: 4/1/2025 | Inventor(s): DaZhi Wang, Zhanpeng Huang, Jianming Liu

Keywords(s): Cardiological Diseases Treatment

Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Therapeutics

Non-Contact, Painless Electroporation and Molecular Transfer Method

Advantages: Permeabilizes cell membranes and tissues without applying a current minimizes the risk of ventricular fibrillation, pain, muscle contractions, and twitching Achieves molecular delivery and cell ablation solely through voltage application, reducing treatment complexity and potential medication side effects Safer modality suitable for...

Published: 3/25/2025 | Inventor(s): Anna Bulysheva, Alex Otten, Jacob Hensley

Keywords(s): Medical Therapeutics Gene Therapy

Category(s): Technology Classifications > Medical > Therapeutics

Novel Potential Treatment for Glioblastoma Multiforme (GBM) via Potent Inhibitor of Atypical Protein Kinase C-iota

Advantages: ICA-1S uniquely inhibits aPKC-ι and Connexin 43, critical proteins in Glioblastoma Multiforme progression Significantly reduces glioblastoma cell proliferation, demonstrating superior efficacy compared to current chemotherapy agents Overcome therapeutic resistance by targeting Connexin 43, enhancing responsiveness to treatment Addressing...

Published: 3/25/2025 | Inventor(s): Mildred Acevedo-Duncan, Grazielly Teodoro

Keywords(s): Cancer Treatment

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics

Brain Cancer: Novel Prognostic Method and Therapeutic Target for Glioblastoma

Advantages: A precision-guided method for identifying glioblastoma-related genes that improves assessment of the current prognostic biomarker Enables the identification of potential novel therapeutic targets: GLP1R agonists, which are already used for managing obesity and type 2 diabetes, could be explored as treatments for GBM Broader Applications:...

Published: 3/24/2025 | Inventor(s): George Blanck, Teresa Thomas

Keywords(s): Cancer Diagnostics, Medical Diagnostics, Oncology, Therapeutics

Category(s): Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Therapeutics

YTH Domain-Containing Family Protein 1 (YTHDF1): A Novel Therapeutic Target for Alzheimer’s Disease

Advantages: A novel method for targeting m6A methylation via YTHDF1 offers a potential therapy for tauopathies and Alzheimer’s disease YTHDF1 reduces neuroinflammation in Alzheimer’s disease by downregulating pro-inflammatory genes like Ccl6 and Cst7 Enhance working memory and reduce hyperactivity in tauopathy, suggesting cognitive...

Published: 3/6/2025 | Inventor(s): Gopal Thinakaran, Shuai Wang

Keywords(s): Animal Models, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics

Ciproloxacin-Based Polyacrylate nanoparticle Emulsions for Antibiotic Applications

Advantages: A water-soluble nanoparticle emulsion with an antibiotic monomer foundation has the ability to fight antibiotic-resistant bacterial infections The emulsion technique facilitates the conversion of antibiotics into nanoparticles that are protected from degradative enzymes The aqueous homo-polymer nanoparticle offers stability, versatility,...

Published: 2/3/2025 | Inventor(s): Edward Turos, Faeez Mahzamani

Keywords(s): Drug Delivery and Nanomedicine, Drug Delivery Systems

Category(s): Technology Classifications > Chemistry, Technology Classifications > Chemistry > Polymers, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Therapeutics

Novel Anti- Aggregation Therapeutic Targets Against Cystic Fibrosis Caused by Pseudomonas Aeruginosa

Advantages: Therapeutic Targets: Identified essential genes in Pa aggregate formation that can be potentially targeted with therapeutics Improved Infection Model: use of synthetic CF sputum media that closely mimics the physical and nutritional environment of CF sputum Potential for Broader Applications: can be extended to other bacterial species...

Published: 2/21/2025 | Inventor(s): Sophie Darch

Keywords(s): Medical Devices, Medical Diagnostics, Therapeutics

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Medical Diagnostics

Treating Age-Related Hearing Loss with Rapamycin and Its Derivatives

Advantages: Novel Application of FDA approved drugs, rapamycin and its derivatives, for treating age-related hearing loss (ARHL). Targeting mTOR alleviates oxidative stress and inflammation in the cochlea, enhancing cellular health and resilience to age-related damage. Potential to Reverse or Delay Age-related hearing loss (ARHL) in patients. Summary: Age-related...

Published: 1/17/2025 | Inventor(s): Robert Frisina, Xiaohua Zhu, Bo Ding, Xiaoxia Zhu

Keywords(s): Pharmaceuticals, Therapeutics

Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices

Antiviral Properties of Deep-Sea Coral Metabolites

Advantages: A novel compound for developing new antiviral drugs extracted from the Irish deep-sea soft coral Anthoteibinene B exhibits significant antiviral activity against Respiratory Syncytial Virus (RSV) without cytotoxic effects N,N-dimethylaminoethyl substituents further enhance antiviral properties by improving solubility, bioavailability,...

Published: 11/7/2024 | Inventor(s): Bill Baker, Stine Olsen, Sam Afoullouss, Kim Teng, Michael Teng, Louise Allcock, Mark Johnson

Keywords(s): Antiviral Therapeutics

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry, Technology Classifications > Medical > Therapeutics

Human Adipose-Derived Stem Cell Exosomes’ Packaging for Use at Room Temperature

Advantages: Promotes wound healing and supports positive long-term outcomes Reduces oxidative stress in human dermal fibroblasts (HDF) by exposing them to a composition containing adipose stem cell-derived exosomes Promising solution specifically tailored for penetrating wounds such as during military combat Summary: Penetrating injuries...

Published: 9/17/2024 | Inventor(s): Niketa Patel

Keywords(s): Wound and Tissue Healing

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Therapeutics

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