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Drug Loading of Donor Corneas for Corneal Transplantation
Advantages Provides a preventative approach to improving vision and reducing post-procedure complications Does not compromise or change donor tissue quality or viability Can be accomplished with a variety of techniques available in the market Drug dose and release can be controlled to meet patient specific needs Summary Partial and full thickness...
Published: 5/28/2025   |   Inventor(s): Christopher Passaglia, Edgar Espana, Emily Checchio
Keywords(s): Ophthalmology, Organ Transplantation
Category(s): Technology Classifications > Medical > Surgery, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology, Technology Classifications > Medical > Therapeutics
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Treating Covid-19 Infection-Induced Dementia
Advantages: Novel gene therapy targeting FKBP5 and IFI204 to disrupt tauopathy-related signaling Targeted RNA delivery utilizing dendriplex nanoparticles to silence SARS-CoV-2 induced neurodegenerative pathways Preclinical animal studies indicate reduction of neuroinflammation and tau accumulation Intranasal delivery bypasses the blood-brain...
Published: 5/27/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Karthick Mayilsamy
Keywords(s): Covid-19, Neuroscience
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Development of an Innovative AI-Enhanced Music-Based Magnetic Respiratory Therapy System
Advantages Uses magnetic sensors to monitor breathing without wires or chest straps AI adapts music in real time to regulate and stabilize respiration Designed for stress relief, respiratory therapy, and sleep quality improvement Comfortable, low-cost, and easy to use for home or clinical settings Summary Patients with respiratory issues whether...
Published: 5/20/2025   |   Inventor(s): Manh-Huong Phan, Dang Nguyen, Kee Young Hwang
Keywords(s): Therapeutics
Category(s): Technology Classifications > Medical > Therapeutics
Gamified Physical Therapy Rehabilitation System
Advantages: Turns muscle movement into gameplay using wearable EMG sensors Personalizes difficulty based on each user’s strength and ability Keeps patients engaged and motivated with real-time feedback and rewards Designed for at-home or clinical use, with easy setup and data tracking Summary: Physical therapy can feel boring and repetitive,...
Published: 5/7/2025   |   Inventor(s): Antonio Gonzalez, Gabriel Mozombite Gallegos, Ashley Pham, Nathan Schilaty, John Templeton, Voon Hee Lee
Keywords(s): Devices for Disabilities / Rehabilitation, Digital Healthcare, Human Computer Interfaces, Medical Devices, Neurodegenerative Diseases, Simulation Training Aid, Wearable Electronics
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Medical Devices
TREM2 Binds to Specifically Structured Heparan Sulfate
Advantages: Discovered novel structural interactions between HS and TREM2, associated with neurodegeneration High-affinity binding: TREM2 specifically interacts with Heparan Sulfate (HS) modified with 6-O-sulfation and iduronic acid, enabling precise microglial modulation compared to broad-spectrum anti-inflammatory strategies. Defined structural...
Published: 5/15/2025   |   Inventor(s): Lianchun Wang, Ilayda McMillan
Keywords(s): Immunology, Neurodegenerative Diseases, Neuroscience
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Novel HPV Epitopes for Designing Cervical Cancer Immunotherapies
Advantages: Specific targeting of HPV epitopes from E2 and E6 proteins opens new avenues for cervical cancer immunotherapies. Correlation of high chemical complementarity scores between TCR CDR3 regions and HPV epitopes with improved overall and disease-free survival provides a reliable biomarker that complement traditional clinical factors. Whole...
Published: 4/24/2025   |   Inventor(s): George Blanck, Deo Rei Agnila, Rahul Jain, Michael Diaz, Tabitha Hudlock, Rachel Eakins, Andrea Chobrutskiy, Boris Chobrutskiy
Keywords(s): Biomarker, Cancer Treatment, Women’s Health
Category(s): Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Womens Health
Wearable Gait and Balance Device for Seniors
Advantages: Integrates lower and upper body support in one discreet wearable system Customizable elastic band tension addresses multiple gait issues, including shuffling, wide-based steps, and foot pronation Real-time feedback via ankle and chest sensors, processed through an intuitive mobile app Concealed wiring and soft fabric design enhance...
Published: 4/24/2025   |   Inventor(s): Justin Irvin, Nathan Schilaty, Souheil Zekri, Vamsi Julapally, Jacob Haefeli
Keywords(s): Devices for Disabilities / Rehabilitation, Health Tech, Medical Devices, Mobility Devices, Mobility Devices and Software, Orthopedic, Sensors, Wearable Electronics, Wearable Monitoring Equipment
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Therapeutics
Novel Method to Treat Heart Disease in Duchenne Muscular Dystrophy (DMD) Patients
Advantages: Novel Therapeutic target to treat cardiac dystrophy in DMD: Nox4 Inhibition Potential to reduce fibrosis and improve cardiac function over conventional treatments Potential to combine NOX4 inhibition with dystrophin replacement therapies Summary: Duchenne Muscular Dystrophy (DMD) is a genetic disorder caused by mutations in the...
Published: 4/1/2025   |   Inventor(s): DaZhi Wang, Zhanpeng Huang, Jianming Liu
Keywords(s): Cardiological Diseases Treatment
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Therapeutics
Non-Contact, Painless Electroporation and Molecular Transfer Method
Advantages: Permeabilizes cell membranes and tissues without applying a current minimizes the risk of ventricular fibrillation, pain, muscle contractions, and twitching Achieves molecular delivery and cell ablation solely through voltage application, reducing treatment complexity and potential medication side effects Safer modality suitable for...
Published: 3/25/2025   |   Inventor(s): Anna Bulysheva, Alex Otten, Jacob Hensley
Keywords(s): Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Therapeutics
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