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Human Adipose-Derived Stem Cell Exosomes’ Packaging for Use at Room Temperature

Advantages: Promotes wound healing and supports positive long-term outcomes Reduces oxidative stress in human dermal fibroblasts (HDF) by exposing them to a composition containing adipose stem cell-derived exosomes Promising solution specifically tailored for penetrating wounds such as during military combat Summary: Penetrating injuries...

Published: 9/17/2024 | Inventor(s): Niketa Patel

Keywords(s): Wound and Tissue Healing

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Therapeutics

Modulating Molecular Chaperone DnaJB6b as a Novel Method to Regulate Tau Seeding and Propagation

Advantages: Semi-high throughput screening accelerates drug discovery by quickly identifying candidates, reducing time to market, and gaining a competitive edge. Molecular Chaperone reduces tau aggregation, preserving cognitive function and improving patient quality. Employs a precision medicine approach targeting tauopathy mechanisms, potentially...

Published: 9/11/2024 | Inventor(s): Abigail Esquivel, Laura Blair

Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics

Method for Treating Melanoma using an Inhibitor of an Atypical Protein Kinase C (PKC)

Advantages: Effectively decreases melanoma cell proliferation and suppresses tumor migration and metastasis. Promotes cancer cell death, specifically targeting melanoma cells and sparing healthy melanocytes. The method not only treats melanoma by targeting atypical PKC isoforms but also utilizes PKC-ι and PKC-ζ levels as biomarkers...

Published: 8/16/2024 | Inventor(s): Mildred Acevedo-Duncan, Wishrawana Ratnayake, David Ostrov

Keywords(s): Cancer Treatment Melanoma

Category(s): Technology Classifications > Cancer > Cancer Treatment Melanoma, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Cancer > Cancer Treatment Adenocarcinomas, Technology Classifications > Medical > Therapeutics, Technology Classifications > Cancer

Methods for Treating Covid-19 Based on Individual Genomic Profiles

Advantages: A high-throughput method offers a rapid and efficient way to predict severe outcomes in COVID-19 patients, facilitating faster clinical decision-making for pulmonary injury. Can be integrated with clinical variables to improve triage across healthcare settings, potentially reducing hospital stays, and optimizing resource allocation...

Published: 7/16/2024 | Inventor(s): Jose Herazo-Maya, Brenda Juan-Guardela, Gaetane Michaud

Keywords(s):

Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics

Treating Kidney Disorders via Targeted Nanoparticles

Advantages: Collagen IV targeted nanoparticles for drug delivery to kidney glomeruli to treat lupus nephritis and other kidney disorders. Therapeutic efficiency: The nanoparticles loaded with prednisone effectively treated lupus nephritis in mice. Reduced systemic toxicity. Summary: Our inventors developed a novel nanoparticle drug delivery...

Published: 5/28/2024 | Inventor(s): Shyam Mohapatra, Ruisheng Liu

Keywords(s): Nanotechnology, Renal / Kidney

Category(s): Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Medical > Therapeutics

Topical Formulations for Treatment of Hypergranulation Tissue

Advantages: Inexpensive and easily manufactured. Fast acting with improvement in the first 72 hours after treatment. No adverse side effects. Summary: Hypergranulation tissue is an excessive growth of granulation tissue in a wound and is a problem that can be encountered in burn care when wounds take a significant time to heal at burn sites...

Published: 9/3/2024 | Inventor(s): Wlliam West

Keywords(s): Dermatology / Skin, Wound and Tissue Healing

Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Therapeutics

Protein-Based Advanced Wound Healing System

Advantages: Inhibits multiple tissue proteases and promotes cell growth. Sustained release of the therapeutic at the wound site. Protease inhibition is easily editable to allow for further targeting of possible bacterial proteases. Can be applied dry, reconstituted, or embedded in materials. Summary: Wound healing is dependent on a balance...

Published: 9/12/2024 | Inventor(s): Graham Strauss, Piyush Koria

Keywords(s): Medical Dressing, Wound and Tissue Healing

Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Biomaterials, Technology Classifications > Medical > Therapeutics

Connector Of Inflammation And Resolution Of Inflammation In Heart Failure

Advantages: ALOX5 expression promotes the synthesis of inflammation resolving factors after infarction ALOX5 deficiency is linked with increased inflammatory signaling and poor outcomes ALOX5 represents a novel potential therapeutic target to treat heart failure Summary: Chronic inflammation is a prime determinant for ischemic and non-ischemic...

Published: 9/3/2024 | Inventor(s): Ganesh Halade, Vasundhara Kain

Keywords(s):

Category(s): Technology Classifications > Medical > Therapeutics

Regulated Delivery of Antibiotic and Antifungal Drugs Via Controlled Degradable Chondroitin Sulfate Particles

Advantages: Novel synthesis of Chondroitin sulfate (CS) particles for encapsulation of antibiotic and antifungal drugs. Synthesis can be fine-tuned to produced non-degradable, slightly degradable, and completely degradable CS drug carriers, for a variety of therapeutic applications. CS particles were successfully tested for encapsulation...

Published: 5/14/2024 | Inventor(s): NURETTIN SAHINER, Ramesh Ayyala

Keywords(s): Drug Delivery and Nanomedicine, Pharmaceuticals

Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical

Drugs That Regulate Heparan Sulfate Expression for Cancer Treatment

Advantages: Developed a novel assay for identifying repurposed drugs targeting HS-related gene expression Revealed a dose-dependent inhibition of the HS-related gene EXT1 with Vitamin D/ Calcitriol EXT1 stable cell line with luciferase reporter ensures specificity in identifying EXT1 regulators, minimizing off-target effects Summary: Heparan...

Published: 9/3/2024 | Inventor(s): Lianchun Wang

Keywords(s): Biotechnology, Cancer Treatment, Medical Therapeutics Gene Therapy

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals

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