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Search Results - technology+classifications+%3e+medical+%3e+therapeutics
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Blocking Necroptosis in Kidney Transplantation: PPP1R3G Targeting to Improve Graft Function and Survival
Advantages Novel Mechanism: Identifies PPP1R3G as a previously unexplored regulatory node in necroptosis during kidney transplantation. Demonstrated Preclinical Efficacy: In animal models, inhibition of PPP1R3G signaling resulted in a ~65% reduction in plasma creatinine and a ~55% improvement in glomerular filtration rate (GFR). Peptidomimetic...
Published: 1/13/2026
|
Inventor(s):
Lei Wang
,
Zhigao Wang
,
Jianfeng Cai
Keywords(s):
Organ Transplantation
,
Renal / Kidney
Category(s):
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Chemistry
,
Technology Classifications > Medical > Therapeutics
Acute Kidney Injury (AKI) Disrupts Cardiac Remodeling via Serpin A3N
Advantages Novel Mechanistic Insight: Identification of SerpinA3N-GZMB axis links AKI to cardiac fibrosis and dysfunction. New Therapeutic Target: targeting SerpinA3N-GZMB axis enables a novel treatment approach for maladaptive cardiac remodeling. Diagnostic and Drug Discovery Potential: SerpinA3N and GZMB could serve as biomarkers for diagnostics...
Published: 10/31/2025
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Inventor(s):
Gowda Pramod
,
Ruisheng Liu
Keywords(s):
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Medical > Medical Diagnostics
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Therapeutics
Exogenous Acetate Formulations for Treating Alcohol Use Disorder and Withdrawal
Advantages Mechanistic Innovation: stabilizes brain energy metabolism and modulates adenosine signaling mechanisms not targeted by current addiction therapies. Targeted Brain Delivery: formulations enable effective acetate transport across the blood-brain barrier, (BBB) Controlled and sustained release Versatile Administration Routes: compatible...
Published: 9/30/2025
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Inventor(s):
Dominic D'Agostino
Keywords(s):
Neuroscience
,
Pharmaceuticals
Category(s):
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Chemistry
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Neuroscience
Novel Heart Failure Therapy: Farnesyltransferase Inhibition Targets Protein Aggregation in Cardiomyocytes
Advantages First-in-Class Mechanism: Targets a novel pathway—protein farnesylation—for heart failure treatment. Broad Therapeutic Potential: Effective in both HFrEF and HFpEF, addressing a major unmet need. Tested in multiple preclinical models: Danon disease cardiomyopathy (genetic model); HFpEF (diet-induced and hypertensive models);...
Published: 11/7/2025
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Inventor(s):
Kunhua Song
,
Congwu Chi
,
Amanda Conniff
Keywords(s):
Cardiovascular Diseases
,
Drug Repurpose
,
Medical Pharmaceuticals
,
Therapeutics
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Chemistry
A Novel Immunomodulatory Strategy for Treating Heart Failure in Aging Populations
Advantages Novel Mechanism of Action: Targets the Th17/IL17A signaling axis Validated Target: IL17A is already clinically validated in other inflammatory diseases (e.g., psoriasis, psoriatic arthritis), with FDA-approved therapies like secukinumab Strong Preclinical POC: transcriptomic, histological, and functional cardiac assessments showing reversal...
Published: 10/14/2025
|
Inventor(s):
Wanling Xuan
,
Srinivas Tipparaju
Keywords(s):
Cardiological Diseases Treatment
,
Cardiovascular Diseases
,
Drug Discovery
Category(s):
zzCardiology
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Therapeutics
Spatiotemporal Drug Control in Autoimmune and Inflammatory Diseases: Photoswitchable JAK2 Inhibitors for Reversible Kinase Modulation
Advantages Precise spatiotemporal control and reversible modulation of kinase activity Reduced systemic toxicity and off-target effects Superior binding affinity and isomer selectivity than traditional Jak 2 inhibitor Summary Janus kinase 2 (JAK2), a key player in hematologic cancers and autoimmune diseases, is a particularly challenging target...
Published: 9/11/2025
|
Inventor(s):
Shelby Kell
,
Chavdar Slavov
Keywords(s):
Autoimmune Diseases
,
Inflammatory Diseases
,
Small Molecules
,
Therapeutics
Category(s):
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
Chemokine Receptor CCR1 as a New Therapeutic Target to Improve Hemorrhagic Shock Resuscitation
Advantages Significant reduction in fluid requirements without noticeable adverse events Clinically tested compound for multiple sclerosis, demonstrating favorable safety and tolerability profile Mitigation of inflammation and tissue edema Broad market potential in major surgeries, sepsis, burn care, and military medicine, where fluid management...
Published: 8/18/2025
|
Inventor(s):
Matthias Majetschak
,
Xianlong Gao
,
Elizabeth Cook
Keywords(s):
Critical Care / Trauma
,
Surgery
Category(s):
Technology Classifications > Medical > Surgery
,
Technology Classifications > Medical > Therapeutics
Methionine Sulfoxide Reductase A (MsrA) Gene Therapy for Retinal Degeneration
Advantaages Targeted Protection Against Oxidative Stress Dual-Vector Delivery System (AAV and Lenti) Simple and scalable plasmid design for efficient production Suitable for major ophthalmology indications: Age-related macular degeneration (AMD), Retinitis pigmentosa, other oxidative stress-related retinal degenerations Summary Oxidative stress...
Published: 10/14/2025
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Inventor(s):
Manas Biswal
Keywords(s):
Ophthalmology
,
Pharmaceuticals
Category(s):
Technology Classifications
,
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Cell & Tissue Engineering
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
Regenerative Extracellular Vesicle (EV) Therapy for Sarcopenia: A Cell-Free Solution for Muscle Aging
Advantages Rejuvenates aged muscle tissue: restoring to youthful state while enhancing muscle mass and strength. Reduces muscle fiber degeneration and inflammation: healthier and more effective muscle regeneration. Effectively reverses age-associated alterations in muscle stem cells (MuSCs), outperforming PBS treatment in aged mice models. Summary Sarcopenia...
Published: 9/11/2025
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Inventor(s):
Wanling Xuan
Keywords(s):
Drug Discovery
,
Medical Pharmaceuticals
,
Therapeutics
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
Gamified Physical Therapy Rehabilitation System
Advantages: Turns muscle movement into gameplay using wearable EMG sensors Personalizes difficulty based on each user’s strength and ability Keeps patients engaged and motivated with real-time feedback and rewards Designed for at-home or clinical use, with easy setup and data tracking Summary: Physical therapy with a licensed physical...
Published: 11/6/2025
|
Inventor(s):
John Templeton
,
Gabriel Mozombite Gallegos
,
Ashley Pham
,
Nathan Schilaty
,
Antonio Gonzalez
,
Voon Hee Lee
Keywords(s):
Devices for Disabilities / Rehabilitation
,
Digital Healthcare
,
Human Computer Interfaces
,
Medical Devices
,
Neurodegenerative Diseases
,
Simulation Training Aid
,
Wearable Electronics
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Medical Devices
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