Search Results - subhra+mohapatra

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Treating Covid-19 Infection-Induced Dementia
Advantages: Novel gene therapy targeting FKBP5 and IFI204 to disrupt tauopathy-related signaling Targeted RNA delivery utilizing dendriplex nanoparticles to silence SARS-CoV-2 induced neurodegenerative pathways Preclinical animal studies indicate reduction of neuroinflammation and tau accumulation Intranasal delivery bypasses the blood-brain...
Published: 5/27/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Karthick Mayilsamy
Keywords(s): Covid-19, Neuroscience
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Novel Combination Treatment for Glioblastoma
Advantages: Temozolomide (TMZ), Cannabidiol (CBD), and CCR6/CCL20 inhibitors work together to overcome Glioblastoma resistance and enhance efficacy Targeted CCL20/CCR6 inhibition blocks survival pathways in glioblastoma, reducing resistance and relapse while improving outcomes Enhances CD8+ T cells and rewires immunity, offering powerful, lasting...
Published: 4/30/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Ryan Green, Karthick Mayilsamy
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
A Method of Delivering Genes and Drugs to the Posterior Eye
Advantages: Non-invasive administration of PAMAM Dendrimer-based eye drop formulation eliminates risks associated with needle-based procedures and reduces cost Hyaluronic acid (HA) on the Dendrimer surface targets overexpressed CD44 receptors on retinal cells, potentially leading to higher bioavailability in the posterior eye Encapsulation of poorly...
Published: 3/10/2025   |   Inventor(s): Shyam Mohapatra, Subhra Mohapatra, Eleni Markoutsa
Keywords(s):  
Category(s): Technology Classifications > Medical > Ophthalmology
Combination Therapy to Treat Viral Acute Respiratory Distress Syndrome (ARDS)
­Advantages: PG’s anti-inflammatory effects mitigate viral inflammation of COVID-19. Intranasally administered mesenchymal stem cells (MSCs) create an anti-inflammatory microenvironment and can enhance neuro-regenerative effects. Targets viral transmission and neuronal damage to reduce virus-induced neuronal damage, and mortality, and...
Published: 7/15/2024   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Mahasweta Das, Andrew McGill, Karthick Mayilsamy
Keywords(s): Covid-19, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory
Withaferin A and Immune Checkpoint Blocker Therapy for The Treatment of Non-Small Cell Lung Cancer
­Advantages: Improved Immunotherapy Outcomes: Significantly enhances the effectiveness of immunotherapy for NSCLC, improving treatment success rates. Personalized Cancer Care: Enables tailored treatments based on individual tumor characteristics, leading to more precise and efficient therapies. Enhanced Safety Profile: Promises a well-tolerated...
Published: 11/14/2023   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Roukiah Khalil
Keywords(s): Cancer Treatment Lung Cancer
Category(s): Technology Classifications > Cancer > Cancer Treatment Lung Cancer
A Liposomal Nanoformulation Encapsulating Linolenic Acid and Acetate Inhibits SARS-CoV-2 Infection
­Advantages: This research offers the potential to combat SARS-CoV-2 and respiratory viruses such as RSV and other coronaviruses. The research addresses various issues of the disease by targeting both the host and viral factors, including reduction in viral replication dampening the excessive immune response. The development of nanoformulations...
Published: 4/24/2025   |   Inventor(s): Andrew McGill, Subhra Mohapatra, Shyam Mohapatra, Eleni Markoutsa, Karthick Mayilsamy
Keywords(s): Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Medical Nanotechnology
Exploring Choroid Plexus Senescence as a Potential Link Between COVID-19 and Alzheimer's Disease
­Advantages: Advances viral neurology research by studying SARS-CoV-2's impact on the aging brain's choroid plexus. Identifies potential biomarkers for neurodegenerative diseases through cellular senescence and SASP factor analysis. Informs public health strategies regarding COVID-19-related neurological complications and preventive...
Published: 2/19/2025   |   Inventor(s): Eleni Markoutsa, Shyam Mohapatra, Subhra Mohapatra
Keywords(s): Infectious Diseases, Neurodegenerative Diseases, Therapeutics
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Method of Treating Long-COVID Induced Neurologic Diseases
­Advantages: Method of preventing AD onset following severe COVID RNA Nano-carrier system carrying dual (brain and CNS)-targeted dendriplexes to target the brain and CNS Summary: COVID-19 is primarily a respiratory disease; however, neurological symptoms are also reported in a subpopulation of infected COVID-19 individuals. Complementary...
Published: 2/19/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Paula Bickford, Laura Blair, Bala Chandran, Karthick Mayilsamy, Ryan Green
Keywords(s):  
Category(s): Technology Classifications > Medical > Neuroscience
RAiD2: Robotics and AI for Onsite Detection and Disinfection
Advantages: Precise and non-contact disinfection User-friendly and portable autonomous operation Robotic and AI-augmented advanced control Business Summary: The RAiD2 platform combats biological threats, particularly during the COVID-19 pandemic. The platform integrates multiplexed nucleic acid-based biosensing for onsite detection, corona...
Published: 9/4/2024   |   Inventor(s): Ying Zhong, Subhra Mohapatra, Shyam Mohapatra, Ehsan Sheybani, Tansel Yucelen
Keywords(s): Artificial Intelligence, Electronics, Infectious Diseases Treatment, Medical Devices, Robotics, Sensors
Category(s): Technology Classifications > Data/AI > D/AI Imaging, Technology Classifications > Electronics > Electronics Sensors, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Engineering > Sensors, Technology Classifications > Medical > Biomaterials, Technology Classifications > Medical, Technology Classifications > Medical > Medical Sensors
Protein Palmiotylation Inhibitors of SARS Viruses
­Competitive Advantages Novel treatment for Covid-19 Inhibits palmitoylation of SARS-CoV-2 spike proteins resulting in reduced virus infectivity Inhibits syncytia formation Summary The last two decades have seen the emergence of three major corona virus(CoV) outbreaks. The SARS-CoV-2 spike glycoprotein (S) is a 1273 amino acids type I membrane...
Published: 8/8/2024   |   Inventor(s): Robert Deschenes, Arunava Roy, Ahmed Ramadan, Subhra Mohapatra, Marcello Giulianotti
Keywords(s): Cell & Tissue Culture & Engineering, Covid-19, Respiratory Diseases, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Respiratory
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