Search Results - respiratory+diseases+treatment

12 Results Sort By:
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Novel PCR-Based Blood Test to Predict Mortality and Monitor Treatment Response for Idiopathic Pulmonary Fibrosis
Advantages IPF Biomarker assay: 6-gene transcriptomic signature strongly correlates with disease severity and mortality across multiple patient cohorts and sample types Non-Invasive Testing: PCR test requires only a blood sample Potential for Precision-Based Therapies: gene-signature panel opens avenues to test targeted therapeutic interventions Identification...
Published: 6/2/2025   |   Inventor(s): Jose Herazo-Maya, Theodoros Karampitsakos
Keywords(s): Medical Diagnostics, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Pharmaceuticals
Mecamylamine as a Therapeutic Agent for SARS-CoV-2
­Advantages: A new method of treating severe acute respiratory syndrome (SARS-CoV-2) Mecamylamine, a nicotinic receptor antagonist, blocks virus and nAChR receptor binding and decreases SARS-COV-2 replication in virus-infected Calu-3 cells Mecamylamine decreases cytokine expression in MHV4-infected IMG cells and manages inflammatory conditions Mecamylamine...
Published: 9/24/2024   |   Inventor(s): Paul Sanberg, Christian Brechot
Keywords(s): Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Infectious Diseases
Combination Therapy to Treat Viral Acute Respiratory Distress Syndrome (ARDS)
­Advantages: PG’s anti-inflammatory effects mitigate viral inflammation of COVID-19. Intranasally administered mesenchymal stem cells (MSCs) create an anti-inflammatory microenvironment and can enhance neuro-regenerative effects. Targets viral transmission and neuronal damage to reduce virus-induced neuronal damage, and mortality, and...
Published: 7/15/2024   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Mahasweta Das, Andrew McGill, Karthick Mayilsamy
Keywords(s): Covid-19, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory
Genistein For Asthma Prevention And Treatment
­Advantages: The research focuses on a tailored approach for managing asthma, specifically on individuals with high PAI-1 genotypes. The research underscores the therapeutic potential of genistein in mitigating asthma severity and associated complications. In vitro and animal data support the efficacy of genistein in reducing allergic inflammation...
Published: 4/16/2025   |   Inventor(s): Seong Cho, Raj Kumar, Brett Anderson, Michael Kaytor
Keywords(s): Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Biotechnology
Soy Isoflavones For Asthma Prevention
­Advantages: This research identified specific genetic markers (PAI-1 polymorphisms) linked to a significant reduction in asthma risk with soy isoflavone treatment. The research incorporates soy isoflavones into asthma management, leveraging the nutritional benefits of this natural compound and a holistic dietary path to respiratory wellness....
Published: 4/30/2025   |   Inventor(s): Seong Cho, Raj Kumar
Keywords(s): Genetics, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Electronics > Food Sciences
New natural product scaffolds with activity against respiratory syncytial virus
­Advantages: This research introduces a novel class of compounds, including neosuberitenone, which demonstrates selectivity against respiratory syncytial virus (RSV). The research's focus on small molecules derived from a natural source, the Antarctic sponge Suberites sp., hints at the potential for cost-effective treatments. The identified...
Published: 7/17/2025   |   Inventor(s): Bill Baker, Joe Bracegirdle, Stine Olsen, Michael Teng, Kim Tran, Charles Amsler, James McClintock
Keywords(s): Antiviral Therapeutics, Infectious Diseases Treatment, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Infectious Diseases
Protein Palmiotylation Inhibitors of SARS Viruses
­Competitive Advantages Novel treatment for Covid-19 Inhibits palmitoylation of SARS-CoV-2 spike proteins resulting in reduced virus infectivity Inhibits syncytia formation Summary The last two decades have seen the emergence of three major corona virus(CoV) outbreaks. The SARS-CoV-2 spike glycoprotein (S) is a 1273 amino acids type I membrane...
Published: 8/8/2024   |   Inventor(s): Robert Deschenes, Arunava Roy, Ahmed Ramadan, Subhra Mohapatra, Marcello Giulianotti
Keywords(s): Cell & Tissue Culture & Engineering, Covid-19, Respiratory Diseases, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Respiratory
Alternative Gαs-promoting agonist Bronchodilator
­Competitive Advantages Novel compounds and methods for selecting targeting β2AR receptors to treat obstructive lung diseases The method might improve airway response with reduced tachyphylaxis Biasing towards β-arrestin and away from G protein coupling can be attained, which can be therapeutically favorable for certain receptors...
Published: 4/22/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Marcello Giulianotti
Keywords(s): Biotechnology, Respiratory Diseases, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Biotechnology
Novel Bronchodilators For Treating Obstructive Lung Disease
­Competitive Advantages Identified novel bronchodilators agonists that relax airway smooth muscle Could be a novel therapeutic for asthma and other obstructive lung diseases Could also be a therapeutic for other types of bronchoconstriction caused by smoke or anaphylaxis Summary Currently patients with obstructive airways diseases have...
Published: 2/19/2025   |   Inventor(s): Stephen Liggett, James Leahy, Donghwa Kim, Steven An
Keywords(s): Medical Therapeutics Cell Therapy, Respiratory Diseases, Respiratory Diseases Treatment, Therapeutics
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics
1 2