Search Results - respiratory+diseases+treatment

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High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Novel PCR-Based Blood Test to Predict Mortality and Monitor Treatment Response for Idiopathic Pulmonary Fibrosis
Advantages Prognostic biomarker assay: Easy PCR blood tests to determine 6-gene signature as an accurate method to stratify IPF patient severity and predict mortality Potential for Precision-Based Therapies: gene-signature panel opens avenues to test targeted therapeutic interventions Identification of Drug Candidates: Identified several drug categories...
Published: 5/22/2025   |   Inventor(s): Jose Herazo-Maya, Theodoros Karampitsakos
Keywords(s): Medical Diagnostics, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Pharmaceuticals
Mecamylamine as a Therapeutic Agent for SARS-CoV-2
­Advantages: A new method of treating severe acute respiratory syndrome (SARS-CoV-2) Mecamylamine, a nicotinic receptor antagonist, blocks virus and nAChR receptor binding and decreases SARS-COV-2 replication in virus-infected Calu-3 cells Mecamylamine decreases cytokine expression in MHV4-infected IMG cells and manages inflammatory conditions Mecamylamine...
Published: 9/24/2024   |   Inventor(s): Paul Sanberg, Christian Brechot
Keywords(s): Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Infectious Diseases
Combination Therapy to Treat Viral Acute Respiratory Distress Syndrome (ARDS)
­Advantages: PG’s anti-inflammatory effects mitigate viral inflammation of COVID-19. Intranasally administered mesenchymal stem cells (MSCs) create an anti-inflammatory microenvironment and can enhance neuro-regenerative effects. Targets viral transmission and neuronal damage to reduce virus-induced neuronal damage, and mortality, and...
Published: 7/15/2024   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Mahasweta Das, Andrew McGill, Karthick Mayilsamy
Keywords(s): Covid-19, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory
Genistein For Asthma Prevention And Treatment
­Advantages: The research focuses on a tailored approach for managing asthma, specifically on individuals with high PAI-1 genotypes. The research underscores the therapeutic potential of genistein in mitigating asthma severity and associated complications. In vitro and animal data support the efficacy of genistein in reducing allergic inflammation...
Published: 4/16/2025   |   Inventor(s): Seong Cho, Raj Kumar, Brett Anderson, Michael Kaytor
Keywords(s): Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Biotechnology
Soy Isoflavones For Asthma Prevention
­Advantages: This research identified specific genetic markers (PAI-1 polymorphisms) linked to a significant reduction in asthma risk with soy isoflavone treatment. The research incorporates soy isoflavones into asthma management, leveraging the nutritional benefits of this natural compound and a holistic dietary path to respiratory wellness....
Published: 4/30/2025   |   Inventor(s): Seong Cho, Raj Kumar
Keywords(s): Genetics, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Electronics > Food Sciences
New natural product scaffolds with activity against respiratory syncytial virus
­Advantages: This research introduces a novel class of compounds, including neosuberitenone, which demonstrates selectivity against respiratory syncytial virus (RSV). The research's focus on small molecules derived from a natural source, the Antarctic sponge Suberites sp., hints at the potential for cost-effective treatments. The identified...
Published: 3/27/2025   |   Inventor(s): Bill Baker, Joe Bracegirdle, Stine Olsen, Michael Teng, Kim Tran, Charles Amsler, James McClintock
Keywords(s): Antiviral Therapeutics, Infectious Diseases Treatment, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Infectious Diseases
A Liposomal Nanoformulation Encapsulating Linolenic Acid and Acetate Inhibits SARS-CoV-2 Infection
­Advantages: This research offers the potential to combat SARS-CoV-2 and respiratory viruses such as RSV and other coronaviruses. The research addresses various issues of the disease by targeting both the host and viral factors, including reduction in viral replication dampening the excessive immune response. The development of nanoformulations...
Published: 4/24/2025   |   Inventor(s): Andrew McGill, Subhra Mohapatra, Shyam Mohapatra, Eleni Markoutsa, Karthick Mayilsamy
Keywords(s): Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Medical Nanotechnology
Protein Palmiotylation Inhibitors of SARS Viruses
­Competitive Advantages Novel treatment for Covid-19 Inhibits palmitoylation of SARS-CoV-2 spike proteins resulting in reduced virus infectivity Inhibits syncytia formation Summary The last two decades have seen the emergence of three major corona virus(CoV) outbreaks. The SARS-CoV-2 spike glycoprotein (S) is a 1273 amino acids type I membrane...
Published: 8/8/2024   |   Inventor(s): Robert Deschenes, Arunava Roy, Ahmed Ramadan, Subhra Mohapatra, Marcello Giulianotti
Keywords(s): Cell & Tissue Culture & Engineering, Covid-19, Respiratory Diseases, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Respiratory
Alternative Gαs-promoting agonist Bronchodilator
­Competitive Advantages Novel compounds and methods for selecting targeting β2AR receptors to treat obstructive lung diseases The method might improve airway response with reduced tachyphylaxis Biasing towards β-arrestin and away from G protein coupling can be attained, which can be therapeutically favorable for certain receptors...
Published: 4/22/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Marcello Giulianotti
Keywords(s): Biotechnology, Respiratory Diseases, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Biotechnology
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