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Search Results - steven+an
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HLA-class II-restricted T Cell Receptors for PIK3CA “Hotspot” Mutations, E545K and N345K
Summary: The National Cancer Institute (NCI) seeks co-development partners and/or licensees for a collection of T cell receptors (TCRs) that specifically target PIK3CA mutations to treat patients with tumors expressing these mutations in the context of HLA-DPA1*01:03:01, HLA-DPB1*04:01:01 or HLA-DRB1*04:01. Description of Technology: Phosphatidylinositol-4,5-biphosphate...
Published: 11/10/2024
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Inventor(s):
Steven Rosenberg
,
NIkolaos Zacharakis
,
S M Rafiqul Islam
,
Samantha Seitter
,
Maria Parkhurst
,
Frank Lowery
Keywords(s):
Category(s):
TherapeuticArea
,
TherapeuticArea > Oncology
,
TherapeuticArea > Immunology
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Collaboration Sought > Collaboration
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Application > Therapeutics
A Process for the Complete Degradation of Perfluoro Alkyl Substances (PFAS) Molecules Using Catalytic Ozonolysis
The Problem: Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals that have been widely used in various industrial and consumer products such as non-stick cookware, water-repellent fabrics, and firefighting foams due to their unique properties of resistance to heat, water, and oil. These chemicals are highly persistent in the...
Published: 11/5/2024
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Inventor(s):
James Shogren-Harris
,
Steven Weinman
,
Alexander Minne
,
Britney Mack
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Healthcare
,
Technology Classifications > Systems & Services
Combination Cancer Therapy Methods and Agents (UCLA Case No. 2024-084)
UCLA researchers from the Department of Medicine, Pathology, & Laboratory Medicine and Molecular & Medical Pharmacology have identified a novel cell-based therapy that leads to enhanced immunotherapy efficacy and overcomes treatment resistance to immune checkpoint blockade in non-small cell lung cancer. BACKGROUND: Non-small cell lung cancer...
Published: 11/4/2024
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Inventor(s):
Bin Liu
,
Steven Dubinett
Keywords(s):
anti-tumor immunity
,
cell-based therapy
,
Immune checkpoint blockade
,
Immunotherapy
,
non-small cell lung cancer
,
treatment resistance
,
Tumor microenvironment
,
Vaccines
Category(s):
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Respiratory And Pulmonary
Novel cermet composite for nuclear waste immobilization
1.5-inch diameter cermet synthesized using hot uniaxial sintering Invention Summary: Nuclear power generates ~10% of electricity globally and ~20% in developed economies. High-level waste, expected to be produced at the back end of advanced reactor fuel cycles, includes metals, oxides, halide salts, and carbon/graphite...
Published: 10/9/2024
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Inventor(s):
Ashutosh Goel
,
John Vienna
,
John McCloy
,
S Sundaram
,
Aditya Kumar
,
Hans-Conrad zur Loye
,
Jake Amoroso
Keywords(s):
Category(s):
Technology Classifications > Energy & Battery
,
Technology Classifications > Physical Sciences & Engineering
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Technology Classifications > Polymers/Composites/Materials
Food Demonstration Guide
The Food Demonstration Guide is a comprehensive resource developed to enhance the quality and safety of food demonstrations conducted under the Arizona Department of Health Services' Supplemental Nutrition Assistance Program Education (SNAP-Ed) and Women, Infants, and Children (WIC) programs. This guide aims to train SNAP-Ed and WIC staff on best...
Published: 10/9/2024
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Inventor(s):
Jennifer Parlin
,
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Creative Works
,
Technology Classifications > Agriculture & Horticulture > Food Science & Nutrition
Enzyme delivery for lung injuries and infections using nebulized solutions and perfluorocarbons
The technology describes methods and compositions for treating lung injuries and infections by delivering enzymes, such as plasminogen activators, to the airway using nebulized solutions and perfluorocarbon carriers. This approach dissolves airway obstructions and supports respiratory function. Background Acute lung injury (ALI) and its severe form,...
Published: 9/9/2024
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Inventor(s):
Robert Williams
,
Steven Idell
Keywords(s):
Category(s):
Life sciences > Therapeutics > Drug delivery
,
Life sciences > Therapeutics > Formulation
Shoot Inducing Genes for Improved Production of Transgenic Plants
This invention, using Agrobacterium gene clusters, enables passive regeneration of transgenic cells without the need for plant hormones Background For plants which are recalcitrant (difficult) to transform, poor performance is usually associated with inadequate DNA delivery or difficult regeneration response. There is a need for improved methods...
Published: 9/5/2024
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Inventor(s):
Greg Goralogia
,
Steven Strauss
Keywords(s):
Agrobacterium
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Biotechnology
,
gene transfer
,
gene-edited
,
transgenic
Category(s):
Agricultural
Improved Lox SItes for Cre Recombination Plants
Provides recombination sites for the most widely used recombinase that facilitate increased plant activity Background Site-specific recombinases are widely used molecular tools for performing DNA manipulations both in vitro and in vivo, with applications in research and biotechnology. This includes deletion, integration, and inversion of target...
Published: 9/5/2024
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Inventor(s):
Greg Goralogia
,
Steven Strauss
Keywords(s):
Recombinase
Category(s):
Biological Materials
,
Agricultural
In the Americas Season 10
In the Americas with David Yetman is an HDTV series that takes an in depth look at the heartland of Arizona, New Mexico, Sonora, and Chihuahua, and its peripheries and brings the region into the spotlight for the general audience. This show undertakes a new approach to travel and adventure with a focus on the western continents and islands. Season 10...
Published: 7/29/2024
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Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Creative Works
Core Administrative Program Suite
This technology comprises a comprehensive set of user-friendly business tools designed to enhance and streamline Core Facilities operations. It includes features like managing purchasing requests, reconciling procurement cards (p-cards), and controlling inventory. These tools are specifically tailored to meet the needs of Core Facilities, providing...
Published: 7/10/2024
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Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Education & Training
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