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Curative Locoregional Therapy Using Ablation or Catheter-Based Embolization of Targeted Hepatocellular Carcinoma by Delivering Supercharged NK Cells and CAR-NK or CAR-T Cells (UCLA Case No. 2023-115)
UCLA researchers in the School of Dentistry and Interventional Radiology have developed a groundbreaking curative treatment for hepatocellular carcinoma that combines locoregional therapy, such as ablation or catheter-based embolization, with targeted delivery of supercharged NK cells and CAR-NK or CAR-T cells, offering a highly effective approach that...
Published: 10/23/2025   |   Inventor(s): Anahid Jewett, Steven Raman, Jason Chiang
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy
Lipid Nanoparticle-Mediated Delivery of Gene Editing Reagents for Targeted Disruption of Oncogenic Drivers in C-Myc Overexpressing Malignancies (UCLA Case No. 2025-9A9)
Contact UCLA Technology Development Group to learn more.
Published: 9/19/2025   |   Inventor(s): Steven Jonas, Tanya Stoyanova
Keywords(s):  
Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Oncology
Co-Deacidification and Dechlorination of Aqueous/Gaseous Streams by Mineral Dissolution (Case No. 2022-173)
Summary UCLA researchers have developed a method and composition for simultaneous deacidification and dechlorination of acidic aqueous solutions (including brines or electrolyte streams enriched in free-chlorine species), using mineral or rock solids containing low-valent metals to neutralize acidity and remove chlorine contaminants. Background Electrolytic...
Published: 9/11/2025   |   Inventor(s): Gaurav Sant, David Jassby, Xin Chen, Dante Simonetti, Steven Bustillos
Keywords(s):  
Category(s): Materials, Materials > Functional Materials, Materials > Membranes, Materials > Nanotechnology, Energy & Environment
Damped Flexural Bipod
The Damped Flexural Bipod is an innovative support structure designed to reduce vibrations in sensitive optical systems without compromising positional stability. By enhancing traditional bipod mounts with advanced constrained layer damping strategies, this technology creates a stable yet responsive support ideal for environments where precision is...
Published: 9/16/2025   |   Inventor(s): Steve Meyer
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Imaging & Optics > Materials & Fabrication, Technology Classifications > Sensors & Controls > Motion & Force
Selective Expansion of Engineered TCR-T Cells for Use in Adoptive Cell Immunotherapy
Summary: The National Cancer Institute (NCI) seeks capable licensees interested in commercializing T cell receptor (TCR)-engineered T cells expressing murine/human hybrid receptors. Description of Technology: TCR-T therapies, particularly those targeting patient-specific neoantigens, remain a promising approach to the treatment metastatic cancers....
Published: 8/25/2025   |   Inventor(s): Steven Feldman, Steven Rosenberg, Drew Deniger
Keywords(s):  
Category(s): Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Selective Expansion of Engineered TCR-T Cells for Use in Adoptive Cell Immunotherapy
Summary: The National Cancer Institute (NCI) seeks capable licensees interested in commercializing T cell receptor (TCR)-engineered T cells expressing murine/human hybrid receptors. Description of Technology: TCR-T therapies, particularly those targeting patient-specific neoantigens, remain a promising approach to the treatment metastatic cancers....
Published: 8/25/2025   |   Inventor(s): Steven Feldman, Steven Rosenberg, Drew Deniger
Keywords(s):  
Category(s): Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Collaboration Sought > Licensing
C8166-45 Cells
Summary: The National Cancer Institute (NCI) seeks licensees for a human T-cell line, C8166-45, transformed by HTLV-1. C8166-45, also known as C63/CRII-2, contains three transcriptionally active proviruses useful for testing biological activities involved in T-cell immortalization and growth. Description of Technology: ...
Published: 8/21/2025   |   Inventor(s): Genoveffa Franchini, Syed Salahuddin, Flossie Wong-Staal, Robert Gallo, Phillip Markham, V Kalyanaraman
Keywords(s):  
Category(s): Application > Research Materials, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Combating Potential Misinformation in Journalism: A Hybrid Framework using LLMs and Heuristic Approaches
Background The rapid dissemination of news is an important factor for the global population to stay up to date with current events, or to make well-informed decisions in dynamic sectors like the stock market. Journalists typically include large amounts of quantitative information using data visualization to help enhance accessibility and comprehension...
Published: 6/17/2025   |   Inventor(s): Arlen Fan, Fan Lei, Steven Corman, Ross Maciejewski
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Physical Science, Cybersecurity
UCLA CRISPR Licensing Program (Multiple Technology Case Numbers)
UCLA CRISPR Licensing Program A major challenge in CRISPR-based gene editing is efficient delivery of the editing system to target cells. UCLA has filed patents on plant viral delivery vectors expressing highly-miniaturized CRISPR systems that may overcome these challenges. The technology is based on recent work from the Jacobsen (UCLA) and Doudna...
Published: 9/12/2025   |   Inventor(s): Steven Jacobsen, Jennifer Doudna
Keywords(s):  
Category(s): Therapeutics > Gene Therapy And Editing
Companion Diagnostic for Immunomodulatory Repair Treatments
This technology is a diagnostic tool designed to help match patients to specific drugs or therapies to treat chronic ischemic heart failure. The platform focuses on immune cells called macrophages, which play a crucial role in the body's response to injury and disease. By promoting a specific type of macrophage known to aid healing, this system...
Published: 5/30/2025   |   Inventor(s): Steven Goldman, Daniel Benson, Adrian Grijalva, Jordan Fink, Jordan Lancaster, Jennifer Koevary, Simar Singh
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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