Search Results - steven+an

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DNA EndosomaL Escape Vehicle Response (DELVR) as a Platform to Boost Antisense Oligonucleotide (ASO) Efficacy

Application A versatile delivery platform for antisense oligonucleotides (ASOs) enabling transient downregulation of protein expression. Key Benefits Broadly boost the efficacy of nucleic acid-based drugs. Drastic reduction in toxicity. DELVR strategy can rescue clinically tested ASOs that didn’t progress to FDA approval due to off-target...

Published: 4/22/2026 | Updated: 4/22/2026 | Inventor(s): Steven Narum, Khalid Salaita

Keywords(s): Gene Therapy and Editing, Nanoparticle Drug Delivery, Platform, Rare and Orphan Disease Treatments, Therapeutics

Category(s): TechPub Algolia > Micro and Nanotechnology

Method for formation, compaction, sealing and disposal of CO2 hydrates on the seabed

Background: The rising levels of atmospheric carbon dioxide (CO2) present a critical global challenge, significantly contributing to climate change and ocean acidification. Current CO2 sequestration methods, such as geological storage, face numerous hurdles, including leakage risks, high costs, and the need for extensive monitoring. An emerging method...

Published: 4/9/2026 | Updated: 4/9/2026 | Inventor(s): Vaibhav Bahadur, Awan Bhati, ManojKumar Lokanathan, Steve Smaha

Keywords(s):

Category(s): Physical sciences > Energy > Renewable, green, or transitional energy, Physical sciences > Environmental & sustainable solutions

Genetically engineered cell surface biosensors for high-throughput detection, screening, and recovery of rare earth elements

This technology uses genetically engineered yeast cells displaying fluorescent sensors to detect and recover rare earth elements from solutions, enabling rapid, specific, and scalable metal screening and extraction using fluorescence signals and high-throughput sorting. Background Rare earth elements (REEs) are a group of 17 chemically similar metals...

Published: 3/30/2026 | Updated: 3/30/2026 | Inventor(s): Manish Kumar, Marcus Benyamin, Steven Zilko, Andrew Ellington, Benjamin Keitz, Randall Hughes

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Synthetic biology

Systems and Methods for Concurrent Biochemical Immunoassay and Cellular Traction Force Measurement in Hydrogels

This invention relates to a platform that couples bead-based immunoassays with 3D traction force microscopy (TFM) within a single hydrogel substrate to quantify time-resolved biochemical cues and cell-generated mechanical forces at matched locations. This invention allows researchers to directly test how local molecular cues influence cell mechanics...

Published: 3/23/2026 | Updated: 3/23/2026 | Inventor(s): Alex McGhee, Kelvin Pond, A Departmental Work

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics > Sensors and Detection, Technology Classifications > Engineering & Physical Sciences > Photonics, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays

Engineered Models of Human Embryo Implantation - Microfabricated Cell Culture Platforms to Increase the Efficiency and Timing of Blastoid Formation and their Lineage Representation (UCLA Case No. 2026-096)

Details available soon. Please contact UCLA Technology Development Group if you have any questions or would like more information in the meantime.

Published: 4/24/2026 | Updated: 3/4/2026 | Inventor(s): Steven Jonas

Keywords(s):

Category(s): Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Women's Health

Gene-Modified Conventional Type 1 Dendritic Cells (UCLA Case No. 2026-093)

Details available soon. Please contact UCLA Technology Development Group if you have any questions or would like more information in the meantime.

Published: 4/3/2026 | Updated: 3/4/2026 | Inventor(s): Steven Dubinett

Keywords(s):

Category(s): Therapeutics > Immunology And Immunotherapy

Dark Eye Harvester

This invention involves using an insulated light-proof chamber that allows the harvesting of eyes or another light-sensitive biomaterial without light exposure, allowing visual rhodopsin to regenerate more efficiently. The chamber has a cylindrical shape and is attached to a chest cooler with handles on top to rotate the walls. The chamber has multiple...

Published: 2/9/2026 | Updated: 2/9/2026 | Inventor(s): A Departmental Work, Michael Brown

Keywords(s):

Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Research Tools

Nanoparticle & dsDNA Toolkit for Decreased Toxicity and Gene Editing of Epithelial Stem Cells via Epithelial Disruption (UCLA Case No. 2023-205/209) -- for Cystic Fibrosis and other genetic diseases

UCLA researchers in the Department of Pediatrics, Hematology/ Oncology have constructed a nanoparticle toolkit for increased integration and reduced toxicity for gene therapies that treat debilitating diseases such as Cystic Fibrosis and other critical genetic diseases. BACKGROUND: Gene therapies are the forefront of therapeutic advancements as a one-off...

Published: 12/1/2025 | Updated: 12/1/2025 | Inventor(s): Steven Jonas, Brigitte Gomperts, Donald Kohn

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Platforms > Drug Delivery

Curative Locoregional Therapy Using Ablation or Catheter-Based Embolization of Targeted Hepatocellular Carcinoma by Delivering Supercharged NK Cells and CAR-NK or CAR-T Cells (UCLA Case No. 2023-115)

UCLA researchers in the School of Dentistry and Interventional Radiology have developed a groundbreaking curative treatment for hepatocellular carcinoma that combines locoregional therapy, such as ablation or catheter-based embolization, with targeted delivery of supercharged NK cells and CAR-NK or CAR-T cells, offering a highly effective approach that...

Published: 10/31/2025 | Updated: 10/23/2025 | Inventor(s): Anahid Jewett, Steven Raman, Jason Chiang

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy

Lipid Nanoparticle-Mediated Delivery of Gene Editing Reagents for Targeted Disruption of Oncogenic Drivers in C-Myc Overexpressing Malignancies (UCLA Case No. 2025-9A9)

Contact UCLA Technology Development Group to learn more.

Published: 9/19/2025 | Updated: 9/19/2025 | Inventor(s): Steven Jonas, Tanya Stoyanova

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Oncology

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