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Search Results - donghwa+kim
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Alternative Gαs-promoting agonist Bronchodilator
Competitive Advantages Novel compounds and methods for selecting targeting β2AR receptors to treat obstructive lung diseases The method might improve airway response with reduced tachyphylaxis Biasing towards β-arrestin and away from G protein coupling can be attained, which can be therapeutically favorable for certain receptors...
Published: 5/23/2024
|
Inventor(s):
Stephen Liggett
,
Donghwa Kim
,
Marcello Giulianotti
Keywords(s):
Biotechnology
,
Respiratory Diseases
,
Respiratory Diseases Treatment
Category(s):
Technology Classifications > Medical > Respiratory
,
Technology Classifications > Medical > Biotechnology
Novel Bronchodilators For Treating Obstructive Lung Disease
Competitive Advantages Identified novel bronchodilators agonists that relax airway smooth muscle Could be a novel therapeutic for asthma and other obstructive lung diseases Could also be a therapeutic for other types of bronchoconstriction caused by smoke or anaphylaxis Summary Currently patients with obstructive airways diseases have...
Published: 5/21/2024
|
Inventor(s):
Stephen Liggett
,
James Leahy
,
Donghwa Kim
,
Steven An
Keywords(s):
Medical Therapeutics Cell Therapy
,
Respiratory Diseases
,
Respiratory Diseases Treatment
,
Therapeutics
Category(s):
Technology Classifications > Medical > Respiratory
,
Technology Classifications > Medical > Therapeutics
A Method to Reduce the Downregulation of Beta2-adrenergic Receptors in Asthma and COPD
Advantages Discovered a new mechanism responsible for ∼50% of the β agonist-promoted down-regulation of β2Ars. Let-7f miRNA reduces β2-adrenergic receptor (β2AR) downregulation in airway smooth muscle cells. Targets microRNA let-7f to mitigate β-agonist-induced tachyphylaxis and improve efficacy in asthma and COPD treatments. Offers...
Published: 8/22/2024
|
Inventor(s):
Stephen Liggett
,
Donghwa Kim
Keywords(s):
Category(s):
Technology Classifications > Medical > Respiratory
,
Technology Classifications > Medical