Search Results - isaac+schiefer

2 Results Sort By:
Allosteric Modulation of Muscarinic Acetylcholine Receptor for Treatment of Neurological Disorders
Project ID: D2022-18 Background Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors that are located in the cell membranes of neurons and mediate the effects of the neurotransmitter acetylcholine (ACh). Each mAChR forms a complex with intracellular G proteins that, when activated, produce an intracellular signaling cascade....
Published: 8/23/2024   |   Inventor(s): William Messer, Hazel Cunningham, Corey Widman, John Ellis, Isaac Schiefer, Gina Kaup
Keywords(s):  
Category(s): Neuroscience
Furoxans as Novel Therapeutics for Neurodegenerative Disorders
Project ID: D2017-15 Background Nitric oxide (NO) signaling plays a major role in brain activity and normal function of neurons. Disrupted NO signaling is implicated in several central nervous system (CNS) and neurodegenerative disorders. NO mimetic, such as nitrates, have been used against a variety of neurological disorders. This is due to the...
Published: 5/9/2024   |   Inventor(s): Isaac Schiefer, Zahoor Shah
Keywords(s): Alzheimer's, Depression, Encephalopathy, Furoxan, Neurodegenerative, Nitrate, NitricOxide, Stroke, Traumatic
Category(s): Neuroscience