Search Results - liyanaaratchige+tillekeratne

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An OCT method to improve scleral lens fitting
Summary The current technology allows for accurate and objective 3-dimensional (3D) mapping of the external limbus, which could ultimately improve the process of scleral lens fitting. Technology Overview Rigid scleral lenses are difficult to fit to patients because they must rest on the eye but vault over the cornea and the limbus, which is the transition...
Published: 1/5/2024   |   Inventor(s): David Huang, Yan Li, Clara Llorens Quintana
Keywords(s): Imaging, Imaging - Other, Software, Software - Diagnostic/Detection
Category(s): Imaging, Software
Coherent Generation Of High-Dimensional Structured Light Using A Hyperdimensional Spin-Orbit Microlaser
The current invention describes next-generation high-capacity noise-resilient communication and computing technology. The invention describes a method to coherently generate high-dimensional structured light, including spin-orbit states, in an integrated and scalable way. Problem: On-chip information technologies are mostly limited to two-level systems...
Published: 10/16/2023   |   Inventor(s): Liang Feng, Zhifeng Zhang, Haoqi Zhao, Li Ge
Keywords(s): Augmented Reality (AR) & Virtual Reality (VR), Optics & Photonics 
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Materials, Technology Classifications > Imaging
Metabolically stable HDAC inhibitors with trifluoromethylpyruvamide as metal-binding group
Project ID: TECH-2023-25 Background Histone Deacetylases (HDACs) have been studied extensively for their role in regulating expression of genes and proteins involved in cancer cell proliferation and migration. The Zinc Binding Group (ZBG) is an essential component of the HDAC inhibitor pharmacophore. It binds to the zinc ion in the enzyme active...
Published: 5/21/2024   |   Inventor(s): Liyanaaratchige Tillekeratne, Endri Karaj, Riddhidev Banerjee, William Taylor
Keywords(s):  
Category(s): Oncology
Novel Ferroptosis Inducers To Treat Cancer
Project ID: D2022-15 Background ferroptosis is a non-apoptotic cell death mechanism impelled by unrestrained accumulation of iron-dependent cellular reactive oxygen (ROS) species leading to membrane lipid peroxidation resulting from intra-cellular antioxidant depletion. Clinical application of ferroptosis agents/drugs has been elusive due to off-target...
Published: 6/18/2024   |   Inventor(s): Liyanaaratchige Tillekeratne, Samkeliso Dlamini, William Taylor
Keywords(s):  
Category(s): Oncology
Ferroptosis-HDAC Inhibitor Hybrids for treating cancer
Project ID: D2022-16 Background Many cancer treatments target cells and induce apoptosis, a cell death mechanism. Due to genetic instability, tumors become more heterogeneous leading to cells that avert molecular signatures that are targeted by the cancer drugs. Drug resistance remains a major impediment to the success of a cancer treatment. Combinatorial...
Published: 6/18/2024   |   Inventor(s): Liyanaaratchige Tillekeratne, Endri Karaj, Shaimaa Sindi, William Taylor
Keywords(s): Cancer, Drug-resistance, HDAC inhibitors, Histone deacetylases , Non-apoptotic cell death
Category(s): Oncology
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Cofilin inhibitor for the treatment of hemorrhagic brain injury-induced inflammation
Project ID D2019-35 Background Cofilin regulates actin filament assembly and organization in most cells, including during macrophage, T-cell, and dendritic activation and migration. Over-activation of cofilin can lead to microglia inflammation in the brain. Although Cofilin has been shown to be involved in the secondary injury of intracerebral hemorrhage...
Published: 11/27/2024   |   Inventor(s): Zahoor Shah, Saleh Alaqel, Liyanaaratchige Tillekeratne
Keywords(s): Cofilin, Hemorrhagic, Stroke
Category(s): Cardiovascular, Renal, & Metabolism, Neuroscience, Inflammation & Immunity
Control Plane System to Safely and Accurately Transfer Large Amounts of Data
Establishes Dedicated Bandwidths and Reserves Specific Channels to Efficiently Convey InformationThis device is designed to control access to a network which can be utilized by a variety of industries to safely and accurately transfer large amounts of data. High Bandwidth Systems are increasingly using control plane for managing the traffic on the network....
Published: 4/21/2023   |   Inventor(s): Sartaj Sahni, Sanjay Ranka, Yan Li, Eun-Sung Jung, Nara Kamath, Nageshwara Rao
Keywords(s): Backend Signaling, Bandwidth Scheduling, broadband technologies, data processing/data interchange, middleware, data protection, storage technology, cryptogr, Dedicated Bandwidth Channels, Future Resource Scheduling, GMPLS, In-Advance Circuit Provisioning, internet technologies/communication (wireless
Category(s): Technology Classifications > Engineering > Computer Science
A new class of HDAC inhibitors with a new metal-binding group
Project ID: D2018-08Background Cancer is group of diseases characterized by uncontrolled growth of abnormal cells. Selectivity towards cancer cells has been challenging, resulting in treatment options with severe side effects. Histone deacetylases (HDAC) are highly expressed in cancer cells and have been investigated for cancer drug development. Out...
Published: 6/18/2024   |   Inventor(s): Liyanaaratchige Tillekeratne, Ayad Al-Hamashi, Samkeliso Dlamini, Abdulateef Alqahtani, Endri Karaj
Keywords(s): Cancer, Drug development, GI-50, Histone deacetylases
Category(s): Oncology
Twistron Mechanical Energy Harvesters
Mechanical energy harvesters are needed for diverse applications, including self-powered wireless sensors, structural and human health monitoring systems, automotive technologies, and the extraction of energy from ocean waves. Until now, few harvesters have been flexible enough to be used as yarns in textiles, and the performance of such yarns has been...
Published: 6/26/2024   |   Inventor(s): Shi Hyeong Kim, Carter Haines, Na Li, Keon Jung Kim, Tae Jin Mun, Changsoon Choi, Jiangtao Di, Shaoli Fang, Seon Jeong Kim, Ray Baughman
Keywords(s): Automotive, Carbon Nanomaterials, Carbon Nanotubes, Electronics, Energy, Cleantech & Environmental, Engineering & Physical Sciences, Renewable Energy, Sensors & Controls, Textiles, Wireless
Category(s): Nanotechnology
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