Search Results - alzheimer%27s

8 Results Sort By:
Rat Model for Alzheimer's Disease
The present invention is directed to a transgenic rat model of Alzheimer's Disease (AD) termed TgF344-19+/-. The invention rat overexpresses two human genes (APPswe and PS1deltaE9 genes), each of which are believed to be independent dominant causes of early-onset AD. The hemizygote exhibits major features of AD pathology (i.e., dense and diffuse amyloid...
Published: 7/25/2024   |   Inventor(s): Daniel (missing inventor) Ye, Robert Cohen
Keywords(s): ALZHEIMER'S, Disease, Model, rat, RXXXXX, TgF344+/-
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Furoxans as Novel Therapeutics for Neurodegenerative Disorders
Project ID: D2017-15 Background Nitric oxide (NO) signaling plays a major role in brain activity and normal function of neurons. Disrupted NO signaling is implicated in several central nervous system (CNS) and neurodegenerative disorders. NO mimetic, such as nitrates, have been used against a variety of neurological disorders. This is due to the...
Published: 5/9/2024   |   Inventor(s): Isaac Schiefer, Zahoor Shah
Keywords(s): Alzheimer's, Depression, Encephalopathy, Furoxan, Neurodegenerative, Nitrate, NitricOxide, Stroke, Traumatic
Category(s): Neuroscience
Development of genetically engineered probes for calcium sensing and manipulation
Calcium levels in cells have critical functions. Moreover, calcium signaling plays a crucial role in the control of neuronal function and plasticity. Consequently, calcium sensing dysfunction can lead to a variety of pathological conditions such as Alzheimer’s disease or neuromuscular disorders such as Dystonia. Changes in neuronal Ca2+ concentration...
Published: 3/4/2024   |   Inventor(s): Venkat Venkataraman, Anuradha Krishnan, Jeffrey Viviano, Jingyi Zhang
Keywords(s): Alzheimer's, Calcium, Genetics, Neurology, Neuromuscular
Category(s): Human Health Care > Therapeutics
Activated Protein C Inhibits p53-Mediated Apoptosis and Acts as a Cell Survival Factor in the Central Nervous System
Applications:Activated protein C (APC), pro-drug, and/or a variant thereof may be used as an inhibitor of apoptosis or cell death and/or a cell survival factor, especially for stressed or injured cells or tissues of the nervous system including subjects with neurodegenerative disorders.Advantages:Novel biological functions (e.g., neuroprotection) can...
Published: 5/7/2024   |   Inventor(s): Berislav Zlokovic, John Griffin
Keywords(s): Aging, Alzheimer's, Neurological, Therapy
Category(s): Therapeutic
Novel Compounds in Treating Autophagy-Related Pathologies
Project IDs: D2015-09 and D2016-81 Background: Autophagy is a self-degradation process of cellular organelles that helps defend against metabolic stress, maintain metabolic equilibrium, arbitrate cell fate decisions, and safeguard genomic stability. Deficient autophagy has been associated with over 100 diseases, and experimental enhancement of autophagy...
Published: 5/9/2024   |   Inventor(s): Kenneth Hensley, Travis Denton
Keywords(s): ALS, Alzheimer's, Autophagy, Lanthionine Ketimine, Parkinson's
Category(s): Neuroscience
Neuropsychological digital assessment test that identifies discrete latencies in response time to identify emergent neurological/nueropsychiatric illness
TechnologyDeclining cognitive health is increasing in the U.S and worldwide. Early detection of impairment is crucial to altering the course of disease. Many cognitive assessments have previously focused on early memory defects, such as those associated with Alzheimer’s, and it is now evident that focused deficits accumulate over several decades...
Published: 3/6/2024   |   Inventor(s): David Libon, Ganesh Baliga, Mary Kerwin, Rod Swenson
Keywords(s): Alzheimer's, Assesments, Cognition, Dementia, Intervention, Neurodegeneration, Quantitative
Category(s): Research Tools, Software, Human Health Care > Biomarkers, Diagnosis and Detection
A Method to Treat Alzheimer’s, Heart and Liver Diseases
Technology Description This technology describes a process for the preparation of the tripeptide glutathione or its precursors to be delivered to the mitochondria for treating age-related conditions, toxicologic exposures, neurodegeneration, heart disease, and liver damage. More specifically, glutathione precursors and derivatives are coupled to a lipophilic...
Published: 5/26/2021   |   Inventor(s): Tory Hagen, Joseph Beckman, Pamela Beilby
Keywords(s): ALS, Alzheimer's, Antioxidant, Cancer, Liver disease, Medical Science & Technologies, Mitochondria, Neurodegenerative disease
Category(s): Biological Materials, Chemical, Diagnostics, Research Tools, Therapeutics
A Model to Study the Role of IL-1ß in Neurodegeneration and Brain Injury
Applications:A novel transgenic mouse model was created to investigate the role of IL1ß in neurodegeneration and brain injury. This model may also be used to test existing and novel drugs and therapies for suppression of neuroinflammation associated with brain disorders.Advantages:Creation of conditionally expressed IL1ß and IL-1A (receptor...
Published: 5/7/2024   |   Inventor(s): M. Kerry O'banion, Stephanos Kyrkanides
Keywords(s): Alzheimer's, Research Tool
Category(s): Research Tools