Search Results - protein%2fpeptide+(non-antibody)

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Pervious Polymersomes For Antioxidant Enzyme Delivery
Pervious polymersomes encapsulate antioxidant agents while allowing reactive oxygen species to enter through diblock copolymer-defined channels. Problem: Reactive oxygen species and oxidative stress are associated with osteoarthritis development and myocardial injury. Direct use of antioxidant enzymes is challenging due to insufficient delivery systems....
Published: 6/11/2026   |   Updated: 6/11/2026   |   Inventor(s): Zhiliang Cheng, Andrew Tsourkas, Ling Qin
Keywords(s): Drug Delivery, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Materials, Technology Classifications > Therapeutics
LNP-Enabled Intracellular Delivery of Recombinant bioPROTACs
Recombinant fusion bioPROTACs are combined with cationic delivery agents and lipid formulations to enable cytosolic entry and on-demand intracellular degradation of target proteins. Tech Title: Technology: Technology: The core construct is a recombinant fusion protein comprising an E3 ubiquitin ligase domain, a small protein binding scaffold, and an...
Published: 6/9/2026   |   Updated: 5/29/2026   |   Inventor(s): Andrew Tsourkas, Alexander Chan
Keywords(s): Protein/Peptide (Non-Antibody), Soft Materials
Category(s): Technology Classifications > Therapeutics
Multipronged Composite Protocol for High-Efficiency Deep Tissue RNA Delivery and Expression
An RNA transfection and protein expression approach comprising lipid nanoparticles, hyaluronic acid, and photostimulation Problem: As the field of cell modification has expanded, researchers have sought more effective methods for nucleic acid (NA) delivery into cells. RNA transfection is easier to facilitate and control than DNA transfection, making...
Published: 5/13/2026   |   Updated: 5/13/2026   |   Inventor(s): James Eberwine, Jai-Yoon Sul, Hyunbum Kim
Keywords(s): Cell Therapy, Gene Editing, Gene Therapy, Platform Technology, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Pharmacological Treatment for Sleep Disorders Improving Sleep Quality & Architecture
Targeting Heat Shock Factor 1 (HSF1) via gene therapy or using pharmacological compounds targeting HSF1 (e.g. geranylgeranylacetone or macrocyclic peptides) can increase sleep stability, promote deeper sleep, reduce sleep fragmentation, and improve recovery from sleep loss. Problem: Millions of people worldwide suffer from disrupted sleep, whether due...
Published: 4/16/2026   |   Updated: 4/14/2026   |   Inventor(s): Akhilesh Basi Reddy, Shintaro Yamazaki
Keywords(s): Aging, Drug Target, Gene Therapy, Neurodegenerative Diseases, Protein/Peptide (Non-Antibody), Small Molecule, Women's Health
Category(s): Technology Classifications > Therapeutics
An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms
Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems. Problem: CRISPR therapies can permanently correct disease-causing genes, but today's CRISPR delivery systems are either too risky or not potent enough. Viral vectors raise red flags...
Published: 1/14/2026   |   Updated: 1/14/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Reducing The Adverse Side Effects Of Using Native T-Cells To Destroy Cancer Cells
A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected. Problem: Compounds which link native T-cells with the surface antigens found on cancer cells have emerged as an effective treatment for blood malignancies and are currently being developed for solid tumors....
Published: 12/8/2025   |   Updated: 4/16/2025   |   Inventor(s): Michael Mitchell, Ningqiang Gong
Keywords(s): Bioengineering, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s): Technology Classifications > Therapeutics
Methods and Sequences for mRNA and Other HIV Vaccine Development
Unique sequences eliciting broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) that could be used to develop effective mRNA-based and other types of HIV vaccine. Problem: Despite decades of research, there is currently no vaccine to prevent HIV infection. A major goal of HIV vaccine programs is to generate bNAbs, which...
Published: 6/10/2026   |   Updated: 3/31/2025   |   Inventor(s): George Shaw, Edward (Ted) Kreider, Beatrice Hahn, Ashwin Skelly, Hui Li, Drew Weissman
Keywords(s): Bioengineering, HIV/AIDS, Immunology, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Vaccines
Deep Learning Model Discovers Antibiotic Drugs in Extinct Organisms Effective Against Drug-Resistant Superbugs
Antibiotic Peptide de-extinction (APEX) is a deep-learning AI solution that can unearth ancient antibiotics to effectively combat superbugs and tackle antibiotic resistance on a global scale. Problem: Escalating antibiotic resistance around the globe has emerged as one of the pressing problems of our time, with antibiotic-resistant infections causing...
Published: 1/7/2026   |   Updated: 6/26/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Fangping Wan
Keywords(s): Bioengineering, Infectious Disease, Platform Technology, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics
Hidden Antibiotics In The Human Proteome For The Treatment Of Antibiotic-Resistant Infections
Antimicrobial peptides computationally mined from the human proteome. Problem: Novel antibiotics are needed to counter the emergence of drug-resistant bacteria as traditional discovery approaches have not yielded new classes of antimicrobials for decades. Antimicrobial resistance (AMR) is a growing public health concern and, thus far, no significant...
Published: 9/18/2025   |   Updated: 1/4/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Marcelo Dos Reis Melo
Keywords(s): Bioengineering, Data Science, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics
Low Toxicity Antimicrobial Peptides To Overcome Antibiotic Resistance
Combining naturally occurring peptides by hybridizing them with known active peptides to synthesize effective antimicrobial peptides with minimal cytotoxicity. Problem: Antibiotic resistance is a significant concern that poses a potential risk of increased harm from future infectious diseases. Consequently, antimicrobial peptides (AMPs) are regarded...
Published: 1/6/2026   |   Updated: 11/3/2023   |   Inventor(s): Cesar de la Fuente-Nunez, Ravi Radhakrishnan, Vani Xavier de Oliveira Junior, Marcelo Der Torossian Torres, Yiming Wang, Cibele Nicolaski Pedron
Keywords(s): Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Chemical Processes and Synthesis
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