Search Results - marcelo+der+torossian+torres

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Deep Learning Model Discovers Antibiotic Drugs in Extinct Organisms Effective Against Drug-Resistant Superbugs
Antibiotic Peptide de-extinction (APEX) is a deep-learning AI solution that can unearth ancient antibiotics to effectively combat superbugs and tackle antibiotic resistance on a global scale. Problem: Escalating antibiotic resistance around the globe has emerged as one of the pressing problems of our time, with antibiotic-resistant infections causing...
Published: 6/27/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Fangping Wan
Keywords(s): Bioengineering, Infectious Disease, Platform Technology, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics
Antimicrobial Peptides (AMPs) Mined from Human Gut Metagenome Are Effective Against Antibiotic Resistant Pathogens
The collective genomes of the human gut microbiome, known as the metagenome, encode peptides that are effective against antibiotic-resistant bacteria. Problem: Antimicrobial resistance poses a major threat to public health. The development of drug-resistance outpaces traditional drug discovery approaches. As a result, the supply of drugs available to...
Published: 6/26/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Ami Bhatt, Erin Brooks
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Bioengineering, Infectious Disease, Microbiome, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Therapeutics
Low-Cost, Point-of-Care Test for Rapid Visual Diagnosis of COVID-19
A rapid, low-cost, portable swab-based SARS-CoV-2 biosensor whose test result can be detected with naked eye Problem: COVID-19 has killed over 2.84 million people worldwide and has disproportionately affected people in lower-income and resource-limited geographies. High-frequency testing can prevent rapid virus spread and reduce COVID-19-related hospitalizations...
Published: 6/26/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Lucas Felipe de Lima, Andre Lopes Ferreira
Keywords(s): Bioengineering, COVID-19, Infectious Disease
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices
Modified Antimicrobial Peptides For Enhanced Antibiotic Properties
Modified antimicrobial peptides with protein sequences for augmenting antimicrobial and antibiofilm properties. Problem: Antibiotic resistant bacteria are becoming more prevalent, while antibiotic innovation has slowed. Novel antimicrobial agents are needed to treat the 35,000 annual deaths from antibiotic resistant infections. While antimicrobial...
Published: 5/7/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Octavio Franco
Keywords(s): Bioengineering, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Hidden Antibiotics In The Human Proteome For The Treatment Of Antibiotic-Resistant Infections
Antimicrobial peptides computationally mined from the human proteome. Problem: Novel antibiotics are needed to counter the emergence of drug-resistant bacteria as traditional discovery approaches have not yielded new classes of antimicrobials for decades. Antimicrobial resistance (AMR) is a growing public health concern and, thus far, no significant...
Published: 1/5/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Marcelo Dos Reis Melo
Keywords(s): Bioengineering, Data Science, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics
Low Toxicity Antimicrobial Peptides To Overcome Antibiotic Resistance
Combining naturally occurring peptides by hybridizing them with known active peptides to synthesize effective antimicrobial peptides with minimal cytotoxicity. Problem: Antibiotic resistance is a significant concern that poses a potential risk of increased harm from future infectious diseases. Consequently, antimicrobial peptides (AMPs) are regarded...
Published: 11/3/2023   |   Inventor(s): Cesar de la Fuente-Nunez, Ravi Radhakrishnan, Vani Xavier de Oliveira Junior, Marcelo Der Torossian Torres, Yiming Wang, Cibele Nicolaski Pedron
Keywords(s): Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Chemical Processes and Synthesis
Non-Toxic, Potent Antimicrobial Peptides Derived From Wasp Venom For Use Against Antimicrobial Resistant (AMR) Pathogens
Synthetic antimicrobial peptides derived from wasp venom to treat antibiotic-resistant infections. Problem: Antibiotics have transformed modern medicine as they are just one of the most effective drugs in history. However, the rise of antimicrobial resistance (AMR) currently threatens to undermine these achievements, posing a major threat to public...
Published: 10/16/2023   |   Inventor(s): Cesar de la Fuente-Nunez, Lucía Ageitos Castiñeiras, Marcelo Der Torossian Torres, Andreia Boaro
Keywords(s): Bioengineering, Immunology, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics
Synthetic Antibiotic Derived From Plasma Protein Human Apolipoprotein B Targets Key Pathogens in Hospital-Acquired Infections
Peptides derived from the human apolipoprotein B that are antimicrobial, anti-inflammatory, highly cytotoxic, and do not select for bacterial resistance. Problem: In 2019, more than 2.8 million people in the U.S. suffered from antibiotic-resistant infections, leading to over 35,000 deaths. Such infections are of great concern, especially for ESKAPE...
Published: 10/16/2023   |   Inventor(s): Cesar de la Fuente-Nunez, Angela Arciello, Angela Cesaro, Marcelo Der Torossian Torres
Keywords(s): Bioengineering, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics
Engineered Wasp Venom for Safe and Effective Antibiotics
A method for manipulating wasp venom peptide to maintain antimicrobial properties while reducing human toxicity. Problem: Almost 20% of global deaths (~11 million) are from sepsis, often caused by bacterial infections. 35,000 of these deaths are due to drug-resistant bacteria, which are becoming more prevalent. Drug-resistant bacteria are also dangerous...
Published: 10/16/2023   |   Inventor(s): Marcelo Der Torossian Torres, Cesar de la Fuente-Nunez
Keywords(s): Bioengineering, Infectious Disease, Inflammation, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Low-cost rapid diagnostic for COVID-19
A COVID-19 diagnostic approach, utilizing a SARS-CoV-2 binding biosensor, that allows for real-time virus detection, without the need for sample processing, ultimately leading to population-level surveillance, outbreak tracking, reduced healthcare costs, improved treatment outcomes, and saved lives. Problem: SARS-CoV-2, the virus that causes COVID-19,...
Published: 1/5/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, William Reis de Araujo
Keywords(s): Bioengineering, COVID-19, Infectious Disease
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Digital Health, Technology Classifications > Hardware & Components