Search Results - kelsey+swingle

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Ionizable Lipid Nanoparticles For In Vivo mRNA Delivery To The Placenta During Pregnancy
Lipid nanoparticles for selective mRNA delivery to the placenta to treat pre-eclampsia, FGR, and other pregnancy-related disorders. Problem: 3-8% of pregnant women experience pre-eclampsia, or insufficient blood flow to the placenta. In severe cases, this can cause fetal growth restriction (FGR), in which the developing fetus cannot receive adequate...
Published: 2/7/2024   |   Inventor(s): Michael Mitchell, Kelsey Swingle
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Platform Technology, Women's Health
Category(s): Technology Classifications > Therapeutics
Amniotic Fluid Stabilized Lipid Nanoparticles (LNPs) for In Utero Intra-Amniotic mRNA Delivery
Nanoparticles for potent encapsulation and delivery of therapeutic molecules for prenatal fetal therapy in the amniotic sac Problem: Many prenatal genetic diseases suffer from ineffective postnatal treatments. For this reason, therapies that are delivered to the fetus before birth hold promise to treat diseases prior to or in the early stages of...
Published: 2/7/2024   |   Inventor(s): Michael Mitchell, Kelsey Swingle, Margaret Billingsley, William Peranteau
Keywords(s): Bioengineering, Cell Therapy, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Nanotechnology, Orphan Disease, Platform Technology
Category(s): Technology Classifications > Therapeutics