Search Results - animal+models

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YTH Domain-Containing Family Protein 1 (YTHDF1): A Novel Therapeutic Target for Alzheimer’s Disease
Advantages: A novel method for targeting m6A methylation via YTHDF1 offers a potential therapy for tauopathies and Alzheimer’s disease YTHDF1 reduces neuroinflammation in Alzheimer’s disease by downregulating pro-inflammatory genes like Ccl6 and Cst7 Enhance working memory and reduce hyperactivity in tauopathy, suggesting cognitive...
Published: 3/6/2025   |   Inventor(s): Gopal Thinakaran, Shuai Wang
Keywords(s): Animal Models, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
A Novel Preclinical Model of Neonatal Necrotizing Enterocolitis
Advantages: Uniquely replicates the clinical scenario of RBC transfusion-exacerbated NEC in anemic neonates, providing a more accurate model than the traditional method Provide superior mechanistic insights, offering precise investigation of molecular pathways compared to in vitro intestinal injury assays Cost-effective and high-throughput experimentation,...
Published: 1/17/2025   |   Inventor(s): Akhil Maheshwari, Mohan Krishnan
Keywords(s): Animal Models, Research Tools
Category(s): Technology Classifications > Medical
Kcnab2 Conditional Knockout Mouse Model
­Advantages: A new Kcnab2 exon 4-floxed mice, suitable for experimental models to study muscle development, regeneration, and pathogenesis Kcnab2 exon 4-floxed mice were successfully generated using CRISPR/Case9 technology Allows for specific study of the Kcanb2 function on skeletal muscle (e.g. TA) without significant changes in the brain...
Published: 1/24/2025   |   Inventor(s): Srinivas Tipparaju
Keywords(s): Animal Models, Cardiological Diseases Treatment, Cardiovascular Diseases
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Cell & Tissue Engineering
The Sudden Head Acceleration & Kinetic Encephalopathy (SHAKEn™) Device for Preclinical Modeling of Rotational Brain Injury
­Advantages: User control to adjust the positioning of the body plate (in the x/y plane) to optimize spinal alignment relative to the axis of rotation prior to insult. An aeronautics-grade angular rate sensor for direct measurement of angular velocity and to calculate rotational acceleration of the head. An electric plug to power accelerations...
Published: 7/18/2024   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Lab Apparatus, Laboratory Devices, Neuroscience, Research Tools
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience
Secreted UBE3A for the Treatment of Neurological Disorders
­Advantages: Novel vector, composition, and method of treating a neurological disorder with UBE3A deficiency. High fidelity to human Angelman syndrome. Facilitates comprehensive symptom representation for diverse treatment investigations. Allows innovative experiments for pioneering treatment development. Summary: Angelman...
Published: 2/27/2025   |   Inventor(s): Kevin Nash
Keywords(s): Animal Models, Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Neuroscience
Conditional FKBP51 Over-expression Transgenic Mouse
­Advantages: Created a transgenic mice model that allows researchers to precisely control the expression of human FKBP51. Offers a tailored approach to studying psychiatric disorders, enabling the development of personalized treatments. Enhances the understanding of the molecular mechanisms underlying psychiatric disorders such as depression,...
Published: 11/13/2024   |   Inventor(s): Chad Dickey(VA) (DECEASED - See Notes), Laura Blair, Bo Zhang
Keywords(s): Animal Models, Psychiatry / Mental Health
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
2020-120 NOVEL MOUSE MODELS FOR GENETICALLY-DIRECTED SPARSE AND COMPLETE LABELING OF BRAIN CELLS FOR ANALYSIS OF BRAIN CELL BIOLOGY AND PATHOLOGY
Researchers in the Jane and Terry Semel Institute for Neuroscience and Human Behaviors at UCLA have developed four novel reporter mouse lines that illuminate morphologies of genetically-defined neurons and glia and can serve as novel platform for testing candidate therapeutics for neurodevelopmental, psychiatric and age-related brain diseases. The tools...
Published: 2/14/2025   |   Inventor(s): William Yang
Keywords(s): Animal Models, Cns, Diagnostic Markers & Platforms, Life Science Research Tools
Category(s): Life Science Research Tools > Animal Models, Platforms > Diagnostic Platform Technologies, Therapeutics > CNS and Neurology
(XN) 2005-059 PTEN Null Cell Lines
PTEN Null Cell LinesBACKGROUNDPTEN (phsosphatase and tensin homolog deleted on chromosome 10) is a tumor suppressor gene identified to be frequently mutated/deleted in various human cancers. Besides carcinogenesis, Pten may play important roles in regulating stem cell activity, insulin action and development. PTEN is a member of the protein tyrosine...
Published: 2/14/2025   |   Inventor(s): Hong Wu, Daniel Freeman
Keywords(s): Animal Models, Cell Lines, Life Science Research Tools, Oncology
Category(s): Life Science Research Tools > Animal Models, Life Science Research Tools > Cell Lines, Life Science Research Tools, Therapeutics > Oncology
2012-120 WNT10B SIGNALING IN TRIPLE NEGATIVE BREAST CANCER
UCLA researchers in the Department of Obstetrics and Gynecology at the David Geffen School of Medicine have developed a new mouse model for Wnt signaling related to triple negative breast cancer. BACKGROUND: Approximately 250,000 people in the US are diagnosed with breast cancer annually. Breast cancer can be separated into different subtypes that are...
Published: 2/14/2025   |   Inventor(s): Gustavo Miranda-Carboni
Keywords(s): Animal Models, Diagnostic Markers & Platforms, Life Science Research Tools, Oncology
Category(s): Life Science Research Tools > Animal Models, Therapeutics > Oncology
2019-005 CREATION OF A HYPO-ALLERGENIC CAT
INTRODUCTION:UCLA researchers in the Department of Radiation Oncology have proposed to use the state-of-art gene-editing techniques to generate hypo-allergenic cats. BACKGROUND:Cat allergy in humans is an immune reaction to allergens produced by cats. Sensitivity to cat allergens is common in populations all over the world, varying from 15% in northern...
Published: 2/14/2025   |   Inventor(s):  
Keywords(s): Animal Models, Life Science Research Tools
Category(s): Life Science Research Tools > Animal Models
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