Search Results - animal+models

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Conditional Hs3st1/4/5 Mouse Lines for In-vivo Study of Heparan Sulfate (HS)
Advantages: Cell and Stage-specific Cre-loxP mediated ablation of Hs3st1/4/5 First-ever floxed alleles for Hs3st4 and Hs3st5 Captures complex neurological and behavioral phenotypes Evaluates drugs on HS pathways and 3-O-sulfation dependent motifs Summary: Heparan sulfate (HS) is a polysaccharide which plays a vital role in various biological...
Published: 6/26/2025   |   Inventor(s): Lianchun Wang
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience
Mouse Model for Direct Visualization of Endothelial Permeability in Disease States: Cdh5-mScarlet Reporter Mouse
Advantages Reporter mouse reliable labels VE-cadherin, replacing the need for difficult immunostaining protocols enables quicker, live, longitudinal imaging of VE-cadherin remodeling and vascular permeability in vivo Far-red mScarlet emission enables clearer deep-tissue imaging and real time quantification of VE-cadherin turnover and junctional...
Published: 6/4/2025   |   Inventor(s): Joshua Scallan
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
RNA Binding Motif 3 (RBM3) Overexpressing Transgenic Mouse
Advantages • RBM3 upregulation reverses multiple tau phosphorylations post-TBI • Novel RBM3 Overexpressing Transgenic Mouse Model allows researchers to study the effects of RBM3 activation on tissue function, brain function, and brain injury Summary Traumatic brain injury (TBI) not only causes immediate neuronal damage but also...
Published: 5/30/2025   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology
Transgenic Foxc2-tdTomato Overexpressing Mouse Model for Study and Screening of Lymphatic Valve Development
Advantages Tissue specific Foxc2 expression with integrated tdTomato fluorescent reporter enables precise spatiotemporal visualization Enables monitoring of lymphatic valve development 1:1 co-expression of Foxc2 and tdTomato, overcoming expression variability characteristic associated with of IRES-based or viral delivery systems Single-vector...
Published: 5/30/2025   |   Inventor(s): Joshua Scallan
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
BAC Transgenic Prox1CreERT2 Mouse Line: Allows for Deletion of 'Floxed' Genes Specifically in the Lymphatic Vasculature
Advantages Distinct BAC backbone allows for transgene integration on a separate chromosome, avoiding linkage and complex breeding schemes observed in current strains. Demonstrates >90% Cre-mediated excision in Prox1+ lymphatic endothelial cells, outperforming previous models which demonstrate ~60-70%. Restricts recombination to lymphatic vasculature...
Published: 5/29/2025   |   Inventor(s): Joshua Scallan
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
Mouse Models for Studying Hyperglycemia-induced Hyperfiltration via NOS1 and NKCC2 Proteins (NOS1Cre / NKCC2ftox / NOS1Cre-NKCC2ftox Mice)
Advantages Future applications for treatment of diabetic nephropathy Three mouse models for utilization in diabetic research Defined mechanism behind glomerular hyperfiltration Summary Our inventors have discovered a novel mechanism of hyperglycemia-induced hyperfiltration via the NOS1 and NKCC2 proteins within the body. By increasing the level...
Published: 6/10/2025   |   Inventor(s): Ruisheng Liu
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
Mouse Models for Studying Hyperglycemia-induced Hyperfiltration via NOS1 and NKCC2 Proteins (NOS1Cre / NKCC2ftox / NOS1Cre-NKCC2ftox Mice)
Advantages Future applications for treatment of diabetic nephropathy Three mouse models for utilization in diabetic research Defined mechanism behind glomerular hyperfiltration Summary: Our inventors have discovered a novel mechanism of hyperglycemia-induced hyperfiltration via the NOS1 and NKCC2 proteins within the body. By increasing the level...
Published: 6/10/2025   |   Inventor(s): Ruisheng Liu
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
Animal Model of Angelman Syndrome
Advantages: Lacks the entire UBE3 gene Removal of all isoforms Removal of all alternate promoters Summary: Angelman Syndrome (AS) is a devastating neurological disorder which affects 1 in every 15,000 people. AS presents with ataxia, frequent smiling, laughter, lack of speech, and severe, debilitating seizures. Epilepsy in AS is often refractory...
Published: 5/12/2025   |   Inventor(s): Edwin Weeber, David Segal, Hennriette O'Geen, Ben Pyles, Scott Dindot
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
Novel Cell Lines and Mouse Model to Study Congenital Heart Defects
Advantages: Mutant mouse lines with various CDK13 mutations Identified cardiac specific CDK13 mutations which mirror heart defect development Genetically modified human induced pluripotent stem cells can be differentiated into different cardiac cell types Provides method for screening potential therapeutic agents for congenital heart defects Summary: Congenital...
Published: 5/9/2025   |   Inventor(s): Joanne Chan, DaZhi Wang
Keywords(s): Animal Models, Cardiovascular Diseases, Cell & Tissue Culture & Engineering
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering
YTH Domain-Containing Family Protein 1 (YTHDF1): A Novel Therapeutic Target for Alzheimer’s Disease
Advantages: A novel method for targeting m6A methylation via YTHDF1 offers a potential therapy for tauopathies and Alzheimer’s disease YTHDF1 reduces neuroinflammation in Alzheimer’s disease by downregulating pro-inflammatory genes like Ccl6 and Cst7 Enhance working memory and reduce hyperactivity in tauopathy, suggesting cognitive...
Published: 5/11/2025   |   Inventor(s): Gopal Thinakaran, Shuai Wang
Keywords(s): Animal Models, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Computer Science
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