Search Results - alzheimer%27s+disease

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Modulating Molecular Chaperone DnaJB6b as a Novel Method to Regulate Tau Seeding and Propagation

Advantages: Semi-high throughput screening accelerates drug discovery by quickly identifying candidates, reducing time to market, and gaining a competitive edge. Molecular Chaperone reduces tau aggregation, preserving cognitive function and improving patient quality. Employs a precision medicine approach targeting tauopathy mechanisms, potentially...

Published: 9/11/2024 | Inventor(s): Abigail Esquivel, Laura Blair

Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics

Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)

Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...

Published: 9/12/2024 | Inventor(s): Jianfeng Cai, Heng Liu

Keywords(s): Alzheimer's Disease, Biotechnology, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience

Methylene Blue and Methylene Violet Analogs as Mitochondrial Therapeutic Agents

Mitochondrial dysfunction has been implicated in a number of diseases, including Alzheimer’s disease (AD), movement disorders, diseases of the cardiovascular system, cancer, diabetes, blindness and deafness. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Membrane-penetrating...

Published: 1/25/2024 | Inventor(s): Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Nishant Visavadiya

Keywords(s): Alzheimer's Disease, Diabetes, Genetic Disorders, Metabolic Disorders, Mitochondrial medicine

Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals

Methylene Blue and Methylene Violet Analogs as Mitochondrial Therapeutic Agents

Published: 1/25/2024 | Inventor(s): Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Indrajit Bandyopadhyay

Keywords(s): Alzheimer's Disease, Diabetes, Genetic Disorders, Metabolic Disorders, Mitochondrial medicine, Neurodegenerative Disorders, Parkinson's Disease, Pharmaceutical

Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals

Multifunctional Radical Quenchers for Mitochondrial Diseases

Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energy effecting defects have been implicated in forms of movement disorders, cardiomyopathy,...

Published: 1/25/2024 | Inventor(s): Sidney Hecht, Omar Khdour, Mohammad Alam, Sriloy Dey, Yana Chen, Arnaud Chevalier

Keywords(s): Alzheimer's Disease, Drug Discovery, Mitochondrial medicine, Neurodegenerative Disorders

Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics

Alkylaminoquinones as Multifunctional Radical Quenchers

Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...

Published: 1/25/2024 | Inventor(s): Sidney Hecht, Manikandadas Mathilakathu Madathil, Omar Khdour

Keywords(s): Alzheimer's Disease, CNS Therapeutics, Drug, Mitochondrial medicine, Neurodegenerative Disorders, Neurological Disorders, Pharmaceutical, Therapeutics

Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals

Gene for Successful Aging Without Cognitive Decline

Title: Biomarker for Successful Aging without Cognitive Decline Current State of the Art: It is estimated that up to one third of adults will experience a gradual decline in cognitive function known as mild cognitive impairment as they age. Individuals with cognitive decline are able to function reasonably well in everyday activities, such as managing...

Published: 6/21/2021 | Inventor(s): Shirley Poduslo

Keywords(s): Aging, Alzheimer's Disease, Therapeutics

Category(s): Diagnostics

Therapeutic Compounds to Enhance Cognition, Counteract Depression and Treat Smoking Addiction

Chemicals Selectively Modulate Cell Receptors Linked to Neurological Disorders in Humans and Other MammalsThese compounds enable effective treatment of neurological disorders involving cognitive deficits (including Alzheimer’s and Parkinson’s diseases), depression and drug dependences such as tobacco (nicotine) and betel nut addictions....

Published: 6/27/2021 | Inventor(s): William Kem, Ferenc Soti, Hong Xing

Keywords(s): Alzheimer's Disease, Anti-Inflammatory, Cognition Enhancer, Dementia, Parkinson's Disease, Post Traumatic Stress Disorder, Schizophrenia, Wound Healing

Category(s): Technology Classifications > Human Health Care > Therapeutics

AAV Vector that Promotes Antioxidant Production for Treatment of Age-Related Macular Degeneration

Gene Therapy Requires Just One Intraocular Injection to Treat Eye Ailment Caused by Oxidative StressThis AAV gene therapy approach provides a one-time treatment to oxidative stress. Sustained oxidative stress can lead to a variety of pathophysiological diseases including age-related macular degeneration, diabetic retinopathy, and amyotrophic lateral...

Published: 12/22/2022 | Inventor(s): Qiuhong Li, Christhian Ildefonso, Alfred Lewin

Keywords(s): Age Related Macular Degeneration, Alzheimer's Disease, Diabetic Retinopathy, Gene Therapy, Macular Degeneration, Retinal Degeneration, uveitis

Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Others

Soluble, Toll-Like Receptor Decoys for Treating Neurodegenerative Diseases

Protein Receptors Provide Immunotherapy Treatments for Proteinopathy DiseasesThese decoy protein receptors can be used to treat neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s and Parkinson’s, affect more than 6 million people in the United States. Over time and with age, the body’s natural protein growth...

Published: 6/27/2021 | Inventor(s): Todd Golde, Thomas Ladd, Pedro Cruz, Yona Levites, Paramita Chakrabarty, Andrew Li

Keywords(s): Alzheimer's Disease, Therapeutics

Category(s): Technology Classifications > Human Health Care > Therapeutics

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