Search Results - prevent

4 Results Sort By:
Monoclonal Antibodies To Prevent or Treat SARS-CoV-2 Infection
The ongoing COVID-19 pandemic, caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2), has created an immense public health, social, and economic burden. Variants of concern continue to emerge that have increased transmissibility, pathogenicity, or both and that reduce the effectiveness of current therapeutics and vaccines. Thus, there is...
Published: 10/28/2024   |   Inventor(s): Patrizia Farci, Kamille West, Peng Zhang, Paolo Lusso, Zhaochun Chen
Keywords(s): antibodies, Cure, Disease, monoclonal, Prevent, SARS-CoV-2
Category(s): Collaboration Sought > Collaboration
Alloreactive T Cell Depletion Method For Preventing Graft-Versus-Host Disease
The invention relates to the use of adenosine to deplete alloreactive T cells from donor grafts to prevent graft-versus-host disease (GVHD). The method includes culturing donor cells that include T cells with recipient antigen presenting cells (APCs) to form a mixture of cells. The recipient’s APCs activate donor T cells. The activated T cells are...
Published: 10/28/2024   |   Inventor(s): Gregory Whitehill, John Barrett, Dhanalakshmi (Donna) Chinnasamy
Keywords(s): Alloreactive, Cell, DEPLETION, Disease, DONOR, GRAFTS, GRAFT-VERSUS-HOST, GVHD, Listed LPM Maddox as of 4/15/2015, LYMPHOCYTE, lymphocytes, Method, Novel, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Prevent, SELECTIVE, Stem, T, YAXXXX
Category(s): Collaboration Sought > Licensing
Prevention and Treatment of Herpes Virus Infection by Inhibition of the JMJD2 Family of Histone Demethylases
Investigators at the NIH have discovered a potential means for preventing or treating a herpes virus infection by inhibiting the activity of the host cell’s histone demethylases. When herpesviruses enter a cell, they are inactivated by cellular defense mechanisms that wrap the viral genome in repressive chromatin structures. In order for viral replication...
Published: 10/28/2024   |   Inventor(s): Yu Liang, Jodi Vogel, Jesse Arbuckle, Thomas Kristie
Keywords(s): Analogs, Chicken pox, CYTOMEGALOVIRUS, DB4XXX, DBXXXX, DEPLETION, Dimethyloxalylglycine, DMOG, DXXXXX, ENZYMES, Ester, FAMILY, HERPES, INFECTIONS, Inhibitors, JMJD, Kaposi Sarcoma, Kaposi's sarcoma; Kaposi sarcoma, Latency, Methyl, N-methoxyoxoacetyl-glycine, Patent Category - Chemistry, Prevent, Reactivation, simplex, Varicella Zoster, virus
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease
Use of Mono-Amine Oxidase Inhibitors to Prevent Herpes Virus Infections and Reactivation from Latency
Available for licensing are methods of using Monoamine Oxidase Inhibitors (MAOIs) to prevent alpha-herpesvirus lytic infections, such as those caused by Herpes simplex virus (HSV-1 or HSV-2) and Varicella zoster virus (VZV), and to possibly prevent the periodic reactivation of these viruses from latency. MAOIs have been historically used to treat depression,...
Published: 10/28/2024   |   Inventor(s): Yu Liang, Thomas Kristie
Keywords(s): BBXXXX, CHEMISTRY, DB4BXX, DB4XXX, DBXXXX, DXXXXX, HERPES, HSV, HSV-1, hsv-2, Infection, INFECTIONS, Inhibitors, Latency, Mono-Amine, Mono-Anine, OXIDASE, Prevent, Reactivation, Reactiviation, Simpex, simplex, Variacella-zoster, Varicella Zoster, virus, VZV, ZOSTER
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease