Search Results - thomas+nutman

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Lymphatic Filariasis Biomarkers for Detection and Surveillance
Lymphatic filariasis (elephantiasis; LF) is a neglected tropical disease that affects over 120 million people throughout the tropics and sub­tropics of Asia, Africa, the Western Pacific, and parts of the Caribbean and South America. LF results from infection with the filarial parasites Wuchereria bancrofti or Brugia malayi. Current methods of confirming...
Published: 4/8/2024   |   Inventor(s): Sasisekha Bennuru, Thomas Nutman
Keywords(s): 2IXXXX, 2XXXXX, Biomarkers, Detection, Filariasis, Lymphatic, Surveillance
Category(s):  
Polyclonal and Monoclonal Antibodies to Human Eosinophil Major Basic Protein, Eosinophil Peroxidase, Eosinophil Cationic Protein, and Eosinophil-Derived Neurotoxin
Reagents particularly useful in configuring multiplex assays for simultaneous measurement and quantification of multiple eosinophil granule proteins and for immunohistochemistry. Ultimately these reagents may be used as diagnostics for many eosinophil-mediated disorders.
Published: 10/28/2024   |   Inventor(s): Richard Davey, Thomas Nutman
Keywords(s): antibodies, BASIC, CATIONIC, EOSINOPHIL, Eosinophil-Derived, Eosionophil, Human, Listed LPM Fenn as of 4/15/2015, MAJOR, monoclonal, Neurotoxin, PEROXIDASE, polyclonal, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, RM, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Recombinant LL-SXP-1 and Plasmid Encoding LL-SXP-1 for the Immunodiagnosis of Loa Loa
A Loa loa specific antigen that can be used as the basis of an immunoassay for the diagnosis of Loa loa infection.
Published: 10/28/2024   |   Inventor(s): Amy Klion, Thomas Nutman
Keywords(s): Immunodiagnosis, LL-SXP1, Loa, RM, VQXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease
Recombinant NIE Antigen from Strongyloides stercoralis
Strongyloides stercoralis is an intestinal nematode endemic that affects an estimated 30 to 100 million people worldwide. Many of these individuals may be asymptomatic for decades. The present invention discloses a NIE recombinant antigen that can be used in improved assays and diagnostics for S. stercoralis infection. The NIE antigen is the only...
Published: 10/28/2024   |   Inventor(s): Ravi Varatharajalu, Franklin Neva, Thomas Nutman
Keywords(s): ANTIGEN, DA2XXX, DAXXXX, DDXXXX, DXXXXX, recombinant, S., SS-NIE, Stercoralis
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease
Diagnostic Assays and Methods of Use for Detection of Filarial Infection
The effort targeting the mosquito borne neglected tropical disease lymphatic filariasis for elimination through mass drug administration by 2020 will require accurate, cost effective methods for detecting early infections. The World Health Organization-recommended immunochromatographic test detects adult Wuchereria bancrofti (Wb) antigen in blood, but...
Published: 10/28/2024   |   Inventor(s): Doran Fink, Joseph Kubofcik, Peter Burbelo, Thomas Nutman
Keywords(s): Bancrofitan, Bancrofti, CONTROL, DA2XXX, DAXXXX, DXXXXX, Filariasis, FOLLOWING, Immunodiagnosis, Lymphatic filariasis (Wuchereria bancrofti, Brugia malayi), MOLECULE, Programs, Specific, Successful, Surveillance, Wuchereria
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Diagnostics
Novel Antigen for Use as Vaccine Against Nematode Infection
This invention describes a new vaccine against Strongyoides stercoralis, which establishes a parasitic infection that affects an estimated 100-200 million people worldwide. The potential for fatal disease associated with S. stercoralis infection and the difficulty in treating hyperinfection underscores the need for prophylactic vaccines against the...
Published: 10/28/2024   |   Inventor(s): David Abraham, Thomas Nutman
Keywords(s): Against, ANTIGEN, DB2XXX, DBXXXX, DC2XXX, DCXXXX, DXXXXX, Immunorcaclive, Infection, Patent Category - Biotechnology, Protection, S., SslR, Stercaralis, Stercoralis, STRONGYLOIDES, Vaccine
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Therapeutics
Compositions and Methods for Detecting Loa loa
Loa loa is a filarial nematode estimated to infect 3-13 million people in Central and Western Africa. In parts of Africa, mass administration of ivermectin is common for onchocerciasis and lymphatic filariasis control. However, some individuals infected with Loa loa microfilariae in high densities are known to experience post-ivermectin severe adverse...
Published: 10/28/2024   |   Inventor(s): Papa Drame, Sasisekha Bennuru, Thomas Nutman
Keywords(s): ANTIGENS, Diagnostics, Listed LPM Fenn as of 4/15/2015, Loa, Microfilariae, Post LPM Assignment Set 20150420, Pre LPM working set 20150418
Category(s): Collaboration Sought > Collaboration
Antigens for Use in Loa Loa Microfilariae Quantitative Immunoassays
Loa loa microfilarial-specific peptide sequences that could be used as a research material as well as for development of immunoassays for detection of Loa loa microfilaremia.
Published: 10/28/2024   |   Inventor(s): Papa Drame, Sasisekha Bennuru, Thomas Nutman
Keywords(s): ANTIGENS, IMMUNOASSAYS, Listed LPM Fenn as of 4/15/2015, Loa, Microfilariae, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, QUANTITATIVE, RM, VQXXXX, WIXXXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, TherapeuticArea > Infectious Disease