Search Results - yifan+zhang

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Mice with humanized telomere homeostasis
Unmet Need: The imperative need for mouse models in advancing research on human aging and tumorigenesis Telomeres play a key role in human aging and tumorigenesis. However, studying telomeres in mouse models presents challenges due to significant difference in telomere length, which is up to 10 times longer than in humans. To address this limitation,...
Published: 10/8/2024   |   Inventor(s): Jiyue Zhu, Shuwen Wang, Fan Zhang, De Cheng
Keywords(s): Animal Research, Biotechnology, Cancer and aging, Genome editing, Human Research, Male Infertility, Telomere and telomerase
Category(s): Technologies > Health & Well-being > Biotechnology
Targeted Therapy for Triple-Negative Breast Cancer
Breast cancer is the second leading cause of death in women and is the most common cancer among women worldwide. There are four main breast cancer subtypes, luminal A, luminal B, HER2-positive and triple-negative. Triple-negative breast cancer (TNBC) is highly invasive and has higher rates of metastasis and a worse prognosis. Metastasis of cancer cells...
Published: 9/12/2023   |   Inventor(s): Shengxi Chen, Xiaojiang Cui, Yi Zhang, Sidney Hecht
Keywords(s):  
Category(s): Life Science (All LS Techs), Advanced Materials/Nanotechnology, Cancer, Cancer Therapeutics, Pharmaceuticals
High-Affinity Mouse Monoclonal Antibodies to GPC-3 for Liver Cancer Research
Abstract: The National Cancer Institute Laboratory of Molecular Biology seeks parties for collaborative research to co-develop and commercialize antibody drug/toxin conjugates as liver cancer therapy and diagnostics.  There is great interest and value in developing more sensitive and efficient agents for earlier detection of hepatocellular cancer (HCC). ...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Yen Phung, Wei Gao, Yifan Zhang
Keywords(s): ANTIBODY, GLYCOPROTEIN, Glypican-3, GPC3, HCC, hepatocellular carcinoma, liver, monoclonal
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing
High-Affinity Rabbit Monoclonal Antibodies for Cancer Treatment
Abstract: Mesothelin is a cell surface protein that is highly expressed in aggressive cancers, such as malignant mesothelioma, ovarian cancer and pancreatic cancer, lung cancer, breast cancer, cholangiocarcinoma, bile duct carcinoma and gastric cancer.  Because of this selective expression, mesothelin is an excellent candidate for targeted therapeutics,...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Ira Pastan, Yen Phung, Yifan Zhang, Raffit Hassan, Wei Gao
Keywords(s): Epitope, MESOTHELIN
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
Masked-Based Learning Method for Neural Network Multiple Task Adaption
Nowadays, one practical limitation of deep neural networks (DNNs) is their high degree of specialization to a single task. This motivates researchers to develop algorithms that can adapt the DNN model to multiple tasks sequentially, while still performing well on past tasks. This process of gradually adapting the DNN model to learn from different...
Published: 4/19/2023   |   Inventor(s): Deliang Fan, Fan Zhang, Li Yang
Keywords(s): Algorithm Development, Computational Machine, Computing Architecture, Cyber-Physical System, Machine Learning, Neural Computing
Category(s): Computing & Information Technology, Physical Science
Photonic FPGA platform to create arbitrary photonic devices by programming the device structure into the platform.
Background The development and design process for electronic integrated circuits is very intensive before a finalized chip design is sent to the chip fab. Most application-specific electronic integrated circuits require a prototyping process that can be accomplished with a field-programmable gate array (FPGA), an electronic circuit which can be reconfigured...
Published: 5/7/2024   |   Inventor(s): Jaime Cardenas Gonzalez, Yi Zhang, Marissa Granados-Baez
Keywords(s):  
Category(s): Nanotechnology
Processing-In-Memory (PIM) Platform for mRNA Quantification
­The study of human genetics is a rapidly expanding field, fueled in part by developments in large-scale protein and genomic sequencing technologies. Biopharmaceutical companies and modern healthcare rely heavily on sequencing technologies and the acquired data to develop new drugs and provide effective treatments to patients. However, the results...
Published: 2/23/2023   |   Inventor(s): Deliang Fan, Fan Zhang, Shaahin Angizi
Keywords(s): Algorithm Development, Biomarker discovery, Computing Architecture, DNA and protein sequencing, Genomics, Proteomics, Sequencing
Category(s): Physical Science, Computing & Information Technology, Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools
Fast and Efficient Max/Min Searching in DRAM
­In the era of big data, min/max searching from bulk data arrays is one of the most important and widely used fundamental operations in data-intensive applications such as sorting, ranking, bioinformatics, data mining, graph processing, and route planning. Online news and social media require real-time ranking using fast min/max searching from...
Published: 2/23/2023   |   Inventor(s): Deliang Fan, Fan Zhang, Shaahin Angizi
Keywords(s): Algorithm Development, Computational Machine, Computing Architecture, Data Center, Data Mining, Microprocessors, Processing
Category(s): Computing & Information Technology, Physical Science
Imaging Inflammation using PET Radioligands that Target Translocator Protein 18?kDa with High Affinity Regardless of Genotype
This technology includes a group of radioligands that label inflammatory cells specifically, accurately, and across different genotypes and can be detected using Positron Emission Tomography (PET). The radioligands target the Translocator protein 18 kDa (TSPO) receptor which is present on the outer mitochondrial membrane and is involved in the production...
Published: 10/28/2024   |   Inventor(s): Robert Innis, Federico Da Settimo, Giorgio Stefancich, Sabrina Taliani, Sabrina Castellano, Claudia Martini, Yi Zhang, Victor Pike
Keywords(s): 18kDa, Emission, Genotype, Human, Listed LPM Fenn as of 4/15/2015, NA1XXX, Positron, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Quantifying/imaging, Radioligands, Regardless, tomography, TSPO, VEXXXX, VNXXXX, WBXXXX, WIXXXX, XCXXXX, XFXXXX
Category(s): TherapeuticArea > Psychiatry/Mental Health, Application > Non-Medical Devices, TherapeuticArea > Neurology, Application > Software / Apps, Application > Diagnostics, Application > Medical Devices, Application > Research Materials
Neutralizing Antibodies to Influenza HA and Their Use and Identification
The effectiveness of current influenza vaccines varies by strain and season, in part because influenza viruses continuously evolve to evade human immune responses. While the majority of seasonal influenza infections cause relatively mild symptoms, each year influenza virus infections result in over 500,000 hospitalizations in the United States and Europe....
Published: 10/28/2024   |   Inventor(s): Robert Bailer, Michael Joyce, John Mascola, Peter Kwong, Sarah Andrews, Paul Thomas, Gwo-Yu Chuang, Adam Wheatley, Yi Zhang, James Whittle, Adrian McDermott
Keywords(s): 1, 2, antibodies, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DXXXXX, GROUP, INFLUENZA, Neutralize, That, Their, Viruses, VLXXXX, WJXXXX, WNXXXX, XAXXXX, XKXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, ResearchProducts > Antibodies, TherapeuticArea > Immunology
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