Search Results - obesity+metabolic+disease+and+diabetes

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Space Shuttle-Inspired Branched Lipid Nanoparticles As Potent mRNA Transporters
Lipid nanoparticles (LNPs) with reversibly attached branched lipid tails for the delivery of mRNA for gene therapy. Problem: Delivery of mRNA to target cells enables the expression of engineered proteins but mRNA is unstable and negatively charged, necessitating a delivery vehicle to ensure its entry into cells. LNPs can ferry mRNA across the cell...
Published: 11/26/2024   |   Inventor(s): Michael Mitchell, Xuexiang Han
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Nanotechnology, Obesity Metabolic Disease and Diabetes, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
LNP Delivery of Gene-Editing Machinery to Cure Hereditary Tyrosinemia Type 1g
Problem: Hereditary tyrosinemia type 1 (HT1) is a genetic metabolic disease caused by the inability to break down tyrosine, an amino acid present in many meats, dairy products, fruits, and nuts. This disease can be fatal within the first few months of life and increases the risk of liver cancer. The current treatment involves a strict drug regimen and...
Published: 7/25/2025   |   Inventor(s): Kiran Musunuru, Madelynn Whittaker, Xiao Wang, William Peranteau, Cara Berkowitz, Ana Dumitru
Keywords(s): Gene Editing, Genetic Disorders, Obesity Metabolic Disease and Diabetes
Category(s): Technology Classifications > Therapeutics
Topical Treatment for Autoimmune Disorders
Treatment method for autoimmune diseases such as diabetes, multiple sclerosis, atherosclerosis, and rheumatoid arthritis using skin application of a vitamin D analog where topical treatment leads to systemic immunoregulation. Problem: Immunomodulatory drugs are typically administered systemically and often lead to severe side effects. Moreover,...
Published: 7/31/2025   |   Inventor(s): Taku Kambayashi
Keywords(s): Immunology, Obesity Metabolic Disease and Diabetes
Category(s): Technology Classifications > Therapeutics
Physiology-independent control algorithm for an artificial pancreas
An insulin pump control system that works automatically without user input Problem: Diabetic patients can use insulin pumps to deliver insulin after a meal. Continuous glucose monitoring (CGM) systems are also used to record glucose levels throughout the day. These systems could be unified via a closed-loop control algorithm to create an artificial...
Published: 1/17/2025   |   Inventor(s): Insup Lee
Keywords(s): Drug Delivery, Obesity Metabolic Disease and Diabetes
Category(s): Technology Classifications > Medical Devices
The g3mclass Software for Multiclass Disease Diagnosis and Reporting.
Diagnostic software to stratify patients on biomarkers and therapeutic targets. Problem: Targeted therapy has revolutionized the treatment of cancer. The efficacy of such therapy is highly dependent on target levels that may increase, decrease, or remain unchanged in the tumor compared to healthy tissue. In clinical practice, the target’s...
Published: 7/25/2025   |   Inventor(s): Marina Guvakova
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Data Science, Drug Target, Immunoncology, Men's Health, Neurology, Obesity Metabolic Disease and Diabetes, Oncology, Software, Surgery, Women's Health
Category(s): Technology Classifications > Animal Health, Technology Classifications > Diagnostics, Technology Classifications > Therapeutics, Technology Classifications > Testing & Measurement