Search Results - vascular+disease

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Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction

SHORT DESCRIPTION Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs. INVENTORS Youyang Zhao* Ann & Robert H Lurie Children's Hospital of Chicago * Principal Investigator NU...

Published: 4/27/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease

Category(s): Life Sciences > Therapeutics

Drug Repurposing for Age-Impaired Vascular Repair in COVID-19, Sepsis, and ARDS

SHORT DESCRIPTION Methods and compositions for treating COVID-19, sepsis, acute respiratory distress syndrome (ARDS), and cardiovascular diseases in elderly patients by either inhibiting vascular endothelial injury/inflammation or promoting FOXM1-dependent endothelial regeneration and vascular repair. INVENTORS Youyang Zhao Northwestern...

Published: 4/27/2026 | Updated: 4/22/2026 | Inventor(s):

Keywords(s): ARDS - Acute Respiratory Distress Syndrome, COVID-19, Immunology, Infectious disease, Inflammation, Pulmonary disease, Therapeutics, Vascular disease, Vascular repair

Category(s): Life Sciences > Therapeutics

Methods for Treatment of Sepsis and Acute Respiratory Distress Syndrome

LU2025-192 INVENTORS Youyang Zhao Colin Evans SHORT DESCRIPTION This invention identifies endothelial ALOX15 and its lipid product, 1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol (POLAR), as key targets for treating sepsis and acute respiratory distress syndrome (ARDS). BACKGROUND Sepsis-induced acute lung injury (ALI) and acute...

Published: 2/16/2026 | Updated: 10/17/2025 | Inventor(s):

Keywords(s): ARDS - Acute Respiratory Distress Syndrome, Lung disease, Sepsis, Therapeutics, Vascular disease, Vascular repair

Category(s): Life Sciences > Therapeutics