Search Results - rorc

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An In-Vitro Cell System Useful For Identification of RORgamma Antagonists
The retinoid-related orphan receptors alpha, beta and gamma (RORalpha, beta and gamma , also referred to as NR1F1, 2 and 3, respectively) comprise a distinct subfamily of nuclear receptors. Study of ROR-deficient mice has implicated RORs in the regulation of a number of biological processes and revealed potential roles for these proteins in several...
Published: 10/28/2024   |   Inventor(s): Yukimasa Takeda, Anton Jetten
Keywords(s): AC5XXX, ACXXXX, AXXXXX, Cell, Cells, CHO, Co-expressing, DEVELOPED, Expression, IDXXXX, IXXXXX, Reporter., RORC, RORE5-Luciferase, RORgamma, RXXXXX, System, TET-ON, Vector, Vitro
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
RORgamma (RORC) Deficient Mice Which Are Useful for the Study of Lymph Node Organogenesis and Immune Responses
The retinoid-related orphan receptor gamma (RORgamma) is a member of the nuclear receptor superfamily. NIH investigators used homologous recombination in embryonic stem cells to generate mice in which the RORgamma gene was disrupted. RORgamma deficient mice lack peripheral and mesenteric lymph nodes and Peyer's patches indicating that ROR expression...
Published: 10/28/2024   |   Inventor(s): Anton Jetten
Keywords(s): Autoimmune, DEFICIENT, Disease, IDXXXX, IMMUNE, IXXXXX, Mice, Responses, RORC, RORgamma, RXXXXX, TOOLS
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Therapeutics, Application > Research Materials, Application > Diagnostics