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GLI-Similar 3(GLIS3) Knock Out (KO) Mice as Models to Screen Therapeutics for Diabetes, Polycystic Kidney Disease, and Hypothyroidism
GLI-similar (Glis) 1-3 proteins constitute a subfamily of the Krüppel-like zinc finger transcription factors that are closely related to the Gli family. Mutations in human GLIS3 have been implicated in a syndrome characterized by neonatal diabetes and congenital hypothyroidism (NDH) and in some patients accompanied by polycystic kidney disease, glaucoma,...
Published: 10/28/2024   |   Inventor(s): Kristin Lichti-Kaiser, Hong Soon Kang, Anton Jetten
Keywords(s): ACXXXX, AXXXXX, GCXXXX, GLIS3, GXXXXX, Knock, KO, Mice, Mice:, RXXXXX, SELECTIVE, TISSUES, Which
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Therapeutics
An In-Vitro Cell System Useful For Identification of RORgamma Antagonists
The retinoid-related orphan receptors alpha, beta and gamma (RORalpha, beta and gamma , also referred to as NR1F1, 2 and 3, respectively) comprise a distinct subfamily of nuclear receptors. Study of ROR-deficient mice has implicated RORs in the regulation of a number of biological processes and revealed potential roles for these proteins in several...
Published: 10/28/2024   |   Inventor(s): Yukimasa Takeda, Anton Jetten
Keywords(s): AC5XXX, ACXXXX, AXXXXX, Cell, Cells, CHO, Co-expressing, DEVELOPED, Expression, IDXXXX, IXXXXX, Reporter., RORC, RORE5-Luciferase, RORgamma, RXXXXX, System, TET-ON, Vector, Vitro
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
RORgamma (RORC) Deficient Mice Which Are Useful for the Study of Lymph Node Organogenesis and Immune Responses
The retinoid-related orphan receptor gamma (RORgamma) is a member of the nuclear receptor superfamily. NIH investigators used homologous recombination in embryonic stem cells to generate mice in which the RORgamma gene was disrupted. RORgamma deficient mice lack peripheral and mesenteric lymph nodes and Peyer's patches indicating that ROR expression...
Published: 10/28/2024   |   Inventor(s): Anton Jetten
Keywords(s): Autoimmune, DEFICIENT, Disease, IDXXXX, IMMUNE, IXXXXX, Mice, Responses, RORC, RORgamma, RXXXXX, TOOLS
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Therapeutics, Application > Research Materials, Application > Diagnostics
Epithelial Cell Line Expressing a Cystic Fibrosis Phenotype
Cystic fibrosis (CF) is a common genetic disease that affects the entire body, producing thick, sticky mucus that clogs the lungs, pancreas, and other organs. It is the most common fatal genetic disease in the United States, and is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR). Researchers at NIEHS have developed...
Published: 10/28/2024   |   Inventor(s): Anton Jetten
Keywords(s): Cystic fibrosis, IB4XXX, IBXXXX, IXXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Pulmonology, Application > Diagnostics, Application > Research Materials