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Search Results - pain
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NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR
NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR Researchers at Stanford University and Washington University have discovered a novel molecular pathway for the treatment of opioid overdose. Opioids are a powerful tool for
pain
management when used in clinical care settings. However, in recent years these drugs have...
Published: 9/24/2024
|
Inventor(s):
Evan Obrien
,
Kaavya Kumar
,
Brian Kobilka
,
Susruta Majumdar
,
Vipin Rangari
Keywords(s):
Opiod
,
Pain
Category(s):
Technology Classifications > Chemistry
COMPOUNDS AS GABA RECEPTOR MODULATORS
COMPOUNDS AS GABA RECEPTOR MODULATORS Researchers at UCSF have developed novel GABA-modulating pharmaceutical compounds that are potential therapeutics for the treatment of chronic
pain
. Neurotransmitters are the building blocks of information transfer in the central nervous system and can modulate action potentials at the synapses of neurons...
Published: 12/5/2023
|
Inventor(s):
Matthew McCarroll
,
Jason Sello
,
David Kokel
,
Allan Basbaum
,
Jarret Weinrich
Keywords(s):
Inhibitor
,
Neuron
,
Pain
Category(s):
Technology Classifications > Biology
ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR AND CANNABINOID RECEPTOR 1
ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR AND CANNABINOID RECEPTOR 1 Researchers at Stanford have synthesized a potential novel class of
pain
relief drugs. Traditional opioids, while highly effective for acute pain management, have historically been prescribed as long-term analgesic treatments despite their well-known addictive properties....
Published: 9/14/2023
|
Inventor(s):
Evan Obrien
,
Brian Kobilka
,
Krishna Kumar
Keywords(s):
Analgesic
,
Opiod
,
Pain
Category(s):
Technology Classifications > Chemistry
Fatty Acid Derivatives and Their Use for the Treatment and Prevention of Autoimmune, Inflammatory, and
Pain
Disorders
Abstract: The discovery and selection of suitable compounds for the treatment and prevention of autoimmune, inflammatory, and
pain
disorders is a significant challenge. Researchers at National Institute of Aging (NIA) mitigated this issue. They discovered and synthesized numerous novel fatty acid derivatives (novel small molecules) that may ameliorate...
Published: 4/8/2024
|
Inventor(s):
Christopher Ramsden
,
Gregory Keyes
Keywords(s):
Autoimmune
,
Inflammation
,
National Institute on Aging (NIA)
,
Pain
,
Ramsden
Category(s):
Collaboration Sought > Licensing
,
Application > Therapeutics
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Immunology
Methods for Amelioration and Treatment of Pathogen-associated Inflammatory Response
This CDC invention provides methods for preventing or treating inflammatory response-linked, infection induced pathologies, which are mediated by endogenous substance P. Substance P is a naturally-occurring and major pro-inflammatory neuromediator or neuromodulator, and elevated levels of substance P have been implicated in numerous inflammation-associated...
Published: 7/25/2024
|
Inventor(s):
Larry Anderson
,
Deborah Moore
,
Ralph Tripp
Keywords(s):
bronchoilitis
,
CAUSED
,
CDC Docket Import
,
CDC Docket Import CDC Prosecuting
,
DB3XXX
,
DB4XXX
,
DBXXXX
,
DISEASES
,
DXXXXX
,
IB3XXX
,
Infection
,
Inflammation
,
INFLAMMATORY
,
Methods
,
nitric oxide
,
OID-NCIRD-DVD
,
P
,
Pain
,
pain
control
,
Prevention
,
Pulmonary
,
RESPONSE
,
RSV
,
RSV virus
,
SUBSTANCE
,
SUBSTANCE p
,
treatment
,
treatment methods
,
vasodilation
,
VASODILATOR
,
VAXXXX
,
VBXXXX
,
VDXXXX
,
VEXXXX
,
VJXXXX
,
VKXXXX
,
VLXXXX
,
VMXXXX
,
VOXXXX
,
VPXXXX
,
WAXXXX
,
WIXXXX
,
WJXXXX
,
WKXXXX
,
WMXXXX
,
XAXXXX
,
XCXXXX
,
YBXXXX
,
YCXXXX
Category(s):
Collaboration Sought > Licensing
,
TherapeuticArea > Ophthalmology
,
TherapeuticArea > Infectious Disease
,
TherapeuticArea > Cardiology
,
TherapeuticArea > Oncology
,
Application > Consumer Products
,
Application > Therapeutics
,
TherapeuticArea > Dental
,
TherapeuticArea > Endocrinology
,
Application > Vaccines
,
ResearchProducts > Antibodies
,
TherapeuticArea > Immunology
,
TherapeuticArea > Neurology
,
Application > Research Materials
,
Application > Diagnostics
,
TherapeuticArea > Geriatrics
Therabot - a Robot Therapy Support System
Technology Overview A therapy support robot designed to aid patients Background A character robot is a social or entertainment robot with which an individual has at least some moral or ethical sense or connection. The robot of discussion appears as biological, expresses itself clearly, well-animated and has a recognizable personality. Technology...
Published: 8/15/2023
|
Inventor(s):
Cindy Bethel
Keywords(s):
Medical Devices
,
Pain
Category(s):
Medical Devices
Neurostimulation Device for the Treatment of Chronic
Pain
Chronic
pain
is a common, complex, and distressing problem that afflicts more than 20 percent (50 million) of the population in the United States and more than 1.9 billion people worldwide. The condition arises from a series of events or injuries, including but not limited to traumatic injury, obesity, congenital disorders, nerve damage and sports injuries....
Published: 2/13/2024
|
Inventor(s):
Xue Wei
,
Jeffrey Hettinger
,
Xiao Hu
,
Robert Hirsh
Keywords(s):
Biocompatible
,
Inflammation
,
Neurostimulation
,
Pain
,
Polymers
,
Protein
Category(s):
Human Health Care > Medical Devices
Wearable Device for Continuous Monitoring and Intelligent Intervening of Targeted Body Region
Traditional treatment for arthritis and other forms of localized inflammation requires the use of an ice pack. For those who suffer from arthritis, accessibility to a cold pack is limited by the need for constant refrigeration. Moreover, physicians do not have a method to continually monitor localized patient inflammation, and this hampers the treatment...
Published: 3/6/2024
|
Inventor(s):
Charles Linderman
,
Hong Zhang
Keywords(s):
Arthritis
,
Cryotherapy
,
Feedback
,
Inflammation
,
Medical Devices
,
Pain
,
Wearable
Category(s):
Human Health Care > Medical Devices
Small Molecule Therapeutics for L-DOPA-Induced Dyskinesia
This invention provides a novel therapeutic for the reduction of levodopa-induced dyskinesia associated with the treatment of Parkinson’s disease. This invention has been demonstrated to have a statistically significant effect upon dyskinesia compared to amantadine, the only drug currently given for dyskinesia treatment. This invention is for...
Published: 6/20/2024
|
Inventor(s):
Ruben Vardanyan
,
Victor Hruby
Keywords(s):
pain
Category(s):
Technology Classifications > Life Sciences > Therapeutics
Discovery of Novel Amphipathic Ligands for the Dynorphin Binding Site on the Bradykinin Receptor
This invention is a dynorphin analog designed to interact with a receptor that is partly responsible for
pain
sensations. Dynorphin analog targets the bradykinin receptors instead of the f NMDA receptors. The ligands are novel in the deletion of an arginine residue in position 7 which has been recognized as an essential residue for opioid and non-opioid...
Published: 4/3/2023
|
Inventor(s):
Yeon Sun Lee
,
Victor Hruby
,
Josephine Lai
,
Frank Porreca
Keywords(s):
[des-Arg7]-dynorphin analogs
,
amphipathic bradykinin receptor
,
non-opioid effect of dynorphin
,
pain
,
pharmacophore
Category(s):
Technology Classifications > Life Sciences
,
Technology Classifications > Life Sciences > Small Molecules