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Search Results - pain
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NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR
NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR Researchers at Stanford University and Washington University have discovered a novel molecular pathway for the treatment of opioid overdose. Opioids are a powerful tool for
pain
management when used in clinical care settings. However, in recent years these drugs have...
Published: 9/24/2024
|
Inventor(s):
Evan Obrien
,
Kaavya Kumar
,
Brian Kobilka
,
Susruta Majumdar
,
Vipin Rangari
Keywords(s):
Opiod
,
Pain
Category(s):
Technology Classifications > Chemistry
COMPOUNDS AS GABA RECEPTOR MODULATORS
COMPOUNDS AS GABA RECEPTOR MODULATORS Researchers at UCSF have developed novel GABA-modulating pharmaceutical compounds that are potential therapeutics for the treatment of chronic
pain
. Neurotransmitters are the building blocks of information transfer in the central nervous system and can modulate action potentials at the synapses of neurons...
Published: 12/5/2023
|
Inventor(s):
Matthew McCarroll
,
Jason Sello
,
David Kokel
,
Allan Basbaum
,
Jarret Weinrich
Keywords(s):
Inhibitor
,
Neuron
,
Pain
Category(s):
Technology Classifications > Biology
ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR AND CANNABINOID RECEPTOR 1
ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR AND CANNABINOID RECEPTOR 1 Researchers at Stanford have synthesized a potential novel class of
pain
relief drugs. Traditional opioids, while highly effective for acute pain management, have historically been prescribed as long-term analgesic treatments despite their well-known addictive properties....
Published: 9/14/2023
|
Inventor(s):
Evan Obrien
,
Brian Kobilka
,
Krishna Kumar
Keywords(s):
Analgesic
,
Opiod
,
Pain
Category(s):
Technology Classifications > Chemistry
Fatty Acid Derivatives and Their Use for the Treatment and Prevention of Autoimmune, Inflammatory, and
Pain
Disorders
Abstract: The discovery and selection of suitable compounds for the treatment and prevention of autoimmune, inflammatory, and
pain
disorders is a significant challenge. Researchers at National Institute of Aging (NIA) mitigated this issue. They discovered and synthesized numerous novel fatty acid derivatives (novel small molecules) that may ameliorate...
Published: 4/8/2024
|
Inventor(s):
Christopher Ramsden
,
Gregory Keyes
Keywords(s):
Autoimmune
,
Inflammation
,
National Institute on Aging (NIA)
,
Pain
,
Ramsden
Category(s):
Collaboration Sought > Licensing
,
Application > Therapeutics
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Immunology
Methods for Amelioration and Treatment of Pathogen-associated Inflammatory Response
This CDC invention provides methods for preventing or treating inflammatory response-linked, infection induced pathologies, which are mediated by endogenous substance P. Substance P is a naturally-occurring and major pro-inflammatory neuromediator or neuromodulator, and elevated levels of substance P have been implicated in numerous inflammation-associated...
Published: 10/28/2024
|
Inventor(s):
Larry Anderson
,
Deborah Moore
,
Ralph Tripp
Keywords(s):
bronchoilitis
,
CAUSED
,
CDC Docket Import
,
CDC Docket Import CDC Prosecuting
,
DB3XXX
,
DB4XXX
,
DBXXXX
,
DISEASES
,
DXXXXX
,
IB3XXX
,
Infection
,
Inflammation
,
INFLAMMATORY
,
Methods
,
nitric oxide
,
OID-NCIRD-DVD
,
P
,
Pain
,
pain
control
,
Prevention
,
Pulmonary
,
RESPONSE
,
RSV
,
RSV virus
,
SUBSTANCE
,
SUBSTANCE p
,
treatment
,
treatment methods
,
vasodilation
,
VASODILATOR
,
VAXXXX
,
VBXXXX
,
VDXXXX
,
VEXXXX
,
VJXXXX
,
VKXXXX
,
VLXXXX
,
VMXXXX
,
VOXXXX
,
VPXXXX
,
WAXXXX
,
WIXXXX
,
WJXXXX
,
WKXXXX
,
WMXXXX
,
XAXXXX
,
XCXXXX
,
YBXXXX
,
YCXXXX
Category(s):
Collaboration Sought > Licensing
,
TherapeuticArea > Ophthalmology
,
TherapeuticArea > Infectious Disease
,
TherapeuticArea > Cardiology
,
TherapeuticArea > Oncology
,
Application > Consumer Products
,
Application > Therapeutics
,
TherapeuticArea > Dental
,
TherapeuticArea > Endocrinology
,
Application > Vaccines
,
ResearchProducts > Antibodies
,
TherapeuticArea > Immunology
,
TherapeuticArea > Neurology
,
Application > Research Materials
,
Application > Diagnostics
,
TherapeuticArea > Geriatrics
Therabot - a Robot Therapy Support System
Technology Overview A therapy support robot designed to aid patients Background A character robot is a social or entertainment robot with which an individual has at least some moral or ethical sense or connection. The robot of discussion appears as biological, expresses itself clearly, well-animated and has a recognizable personality. Technology...
Published: 8/15/2023
|
Inventor(s):
Cindy Bethel
Keywords(s):
Medical Devices
,
Pain
Category(s):
Medical Devices
Neurostimulation Device for the Treatment of Chronic
Pain
Chronic
pain
is a common, complex, and distressing problem that afflicts more than 20 percent (50 million) of the population in the United States and more than 1.9 billion people worldwide. The condition arises from a series of events or injuries, including but not limited to traumatic injury, obesity, congenital disorders, nerve damage and sports injuries....
Published: 12/9/2024
|
Inventor(s):
Xue Wei
,
Jeffrey Hettinger
,
Xiao Hu
,
Robert Hirsh
Keywords(s):
Biocompatible
,
Inflammation
,
Neurostimulation
,
Pain
,
Polymers
,
Protein
Category(s):
Human Health Care > Medical Devices
Small Molecule Therapeutics for L-DOPA-Induced Dyskinesia
This invention provides a novel therapeutic for the reduction of levodopa-induced dyskinesia associated with the treatment of Parkinson’s disease. This invention has been demonstrated to have a statistically significant effect upon dyskinesia compared to amantadine, the only drug currently given for dyskinesia treatment. This invention is for...
Published: 6/20/2024
|
Inventor(s):
Ruben Vardanyan
,
Victor Hruby
Keywords(s):
pain
Category(s):
Technology Classifications > Life Sciences > Therapeutics
Discovery of Novel Amphipathic Ligands for the Dynorphin Binding Site on the Bradykinin Receptor
This invention is a dynorphin analog designed to interact with a receptor that is partly responsible for
pain
sensations. Dynorphin analog targets the bradykinin receptors instead of the f NMDA receptors. The ligands are novel in the deletion of an arginine residue in position 7 which has been recognized as an essential residue for opioid and non-opioid...
Published: 4/3/2023
|
Inventor(s):
Yeon Sun Lee
,
Victor Hruby
,
Josephine Lai
,
Frank Porreca
Keywords(s):
[des-Arg7]-dynorphin analogs
,
amphipathic bradykinin receptor
,
non-opioid effect of dynorphin
,
pain
,
pharmacophore
Category(s):
Technology Classifications > Life Sciences
,
Technology Classifications > Life Sciences > Small Molecules