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Search Results - jianfeng+cai
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Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR for Cancer Treatment
Advantages: Novel cyclic γ-AA peptide (M-2-5) effectively binds with EGFR and inhibits tumor growth in an A549 lung cancer xenograft model. M-2-5 interferes with EGFR-EGF binding, prevents EGFR phosphorylation, and suppresses cancer cell proliferation and migration. Targets the extracellular domain of EGFR with high affinity and specificity....
Published: 7/29/2024
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Inventor(s):
Jianfeng Cai
,
Mengmeng Zheng
Keywords(s):
Category(s):
Technology Classifications > Cancer
Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)
Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...
Published: 9/12/2024
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Inventor(s):
Jianfeng Cai
,
Heng Liu
Keywords(s):
Alzheimer's Disease
,
Biotechnology
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Neuroscience
Novel Peptide-Based Inhibitors of HIF-1α for Cancer Therapy
Advantages: Developed helical mimetics of HIF-1α based on sulfonyl-γ-AA peptides that selectively target HIF-1α to target metastasis and therapy resistance in solid tumors. Inhibitors are stable and cell permeable. HC11, HC13, and HC14 sulfonyl-γ-AA peptides efficiently inhibit HIF-1α activity and reduce expression...
Published: 9/3/2024
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Inventor(s):
Jianfeng Cai
,
Sami Abdulkadir
Keywords(s):
Cancer Treatment
Category(s):
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Oncology
Novel small molecule targeting lncRNA in neurodegenerative diseases and tauopathies
Advantages: Developed lead compound #67 to elevate GAS5 levels and also enhances neuronal insulin signaling, offering a comprehensive approach to neurodegenerative complexities. Noninvasive Insights: GAS5's presence as a serum biomarker enables noninvasive disease assessment and NPC86 treatment efficacy confirmation. Compound #67's...
Published: 3/14/2024
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Inventor(s):
Niketa Patel
,
Jianfeng Cai
Keywords(s):
Medical Therapeutics Gene Therapy
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Neuroscience
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023
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Inventor(s):
Jianfeng Cai
,
Shibo JIANG
,
Lu LU
,
Songyi XUE
,
Xinling WANG
,
Lei WANG
,
Wei XU
,
Shuai XIA
Keywords(s):
Drug Discovery
,
Immunology
Category(s):
Technology Classifications > Medical > Biotechnology
Activation of E6Ap/Ube3A-Mediated Protein Ubiquitination and Degradation Pathways By A Cyclic G-Aa Peptide
Advantages By modulating E3 ligase activity, it is possible to regulate protein degradation pathways, gene activation, and other cellular functions. The research expands the therapeutic landscape by introducing the concept of E3 activators alongside E3 inhibitors, PROTACs, and molecular glues. Synthetic ligands, such as γ-AA peptides, offer...
Published: 4/18/2024
|
Inventor(s):
Jianfeng Cai
,
Bo Huang
,
Jun Yin
,
Li Zhou
,
Ruochuan Liu
Keywords(s):
Cancer Treatment
,
Drug Discovery
,
Neurodegenerative Diseases
,
Oncology
Category(s):
Technology Classifications > Medical > Cell & Tissue Engineering
,
Technology Classifications > Medical > Neuroscience
Novel Vascular Endothelial Growth Factor Mimetics as Inhibitors or Activators of Angiogenesis
Advantages: Novel helical VEGF mimicking peptides that can inhibit or activate angiogenesis. Mimetics hold promise as therapeutic agents for intervention in angiogenesis-related diseases. The sulfono-γ-AA peptides exhibit remarkable stability against proteolytic hydrolysis, ensuring their durability and effectiveness in biological systems. Summary: Angiogenesis,...
Published: 6/11/2024
|
Inventor(s):
Jianfeng Cai
,
Sami Abdulkadir
Keywords(s):
Cancer
,
Peptides
,
Therapeutics
Category(s):
Technology Classifications > Cancer
,
Technology Classifications > Medical > Oncology
,
Technology Classifications > Medical > Therapeutics
Peptidomimetic-Based Antibody Surrogate for HER2
Advantages: High affinity for HER2 and inhibits downstream signaling Potent anti-tumor effects Small molecular weight Resistant to proteolysis Summary: Current HER2-targeted therapies, including monoclonal antibody trastuzumab, are hindered by high cost of production, large molecular weight, and susceptibility to degradation. A novel...
Published: 8/24/2023
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Inventor(s):
Jianfeng Cai
,
Mengmeng Zheng
Keywords(s):
Antibodies
,
Antiviral Therapeutics
,
Cancer
,
Peptides
Category(s):
Technology Classifications > Cancer > Cancer Treatment Breast Cancer
A Novel Sulfono-γ-AApeptides as Potential Treatment for Neurological Disease and Promote Neuron Generation
Competitive Advantages Could be an effective treatment for Alzheimer Might be able to fix neuronal damage and promote neuron growth Minimal toxicity thus would minimize the side effects Summary Effective therapies and/or cures for central nervous system (CNS) disorders like Alzheimer’s which impose a tremendous socioeconomic burden...
Published: 5/24/2024
|
Inventor(s):
Chuanhai Cao
,
Jianfeng Cai
Keywords(s):
Neurodegenerative Diseases
,
Neuroscience
,
Peptides
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Medical > Neuroscience
Novel Ligands as Potential Agents for the Treatment of Neurodegenerative Diseases
Competitive Advantages Treats underlying cause of AD instead of just treating symptoms Disrupts the aggregation of AD-causing proteins Has the potential to prevent or reverse AD and other related neurodegenerative diseases Summary Alzheimer’s Disease is a complex neurodegenerative condition that afflicts 25 million people worldwide. Current...
Published: 6/25/2024
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Inventor(s):
Jianfeng Cai
,
Chuanhai Cao
Keywords(s):
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Medical > Neuroscience
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