Search Results - pharmaceutical

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Methylene Blue and Methylene Violet Analogs as Mitochondrial Therapeutic Agents
Mitochondrial dysfunction has been implicated in a number of diseases, including Alzheimer’s disease (AD), movement disorders, diseases of the cardiovascular system, cancer, diabetes, blindness and deafness. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Membrane-penetrating...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Indrajit Bandyopadhyay
Keywords(s): Alzheimer's Disease, Diabetes, Genetic Disorders, Metabolic Disorders, Mitochondrial medicine, Neurodegenerative Disorders, Parkinson's Disease, Pharmaceutical
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
Alkylaminoquinones as Multifunctional Radical Quenchers
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Manikandadas Mathilakathu Madathil, Omar Khdour
Keywords(s): Alzheimer's Disease, CNS Therapeutics, Drug, Mitochondrial medicine, Neurodegenerative Disorders, Neurological Disorders, Pharmaceutical, Therapeutics
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
Controlling bacterial growth using conditional bacterial extracellular vesicle/exosomes
Unmet Need: Antibiotic resistance makes existing front-line antibiotics ineffective and is attributed to more than 1 million deaths annually The World Health Organization calls antibiotic resistance “one of the biggest threats to global health, food security, and development today”. Microbes resistant to front-line antibiotics are attributed...
Published: 3/14/2024   |   Inventor(s): Wenji Dong, marwa aly
Keywords(s): Antibiotic Resistance, Bacterial infection, Bacterial superbug, Clinical microbiology, Clinics and hospitals, Pharmaceutical
Category(s): Technologies > Health & Well-being > Community Health & Safety
Novel Bifunctional Catalyst and Methods for Synthesis of Optically Pure ß-Lactones
Project ID: D2010-06 Invention novelty: The disclosed invention embodies a novel cobalt based bifunctional catalyst and the process to synthesize enantiomerically pure ( > 99 % ee) β-lactones. Value proposition: Enantiomerically pure β-lactones have found attraction as intermediates in the synthesis of a large number of chiral drugs....
Published: 5/9/2024   |   Inventor(s): Yun-Ming Lin
Keywords(s): Catalyst, Enantiomers, Lactones, Pharmaceutical
Category(s): Catalysts, Manufacturing
A Novel High-Throughput Assay for Identifying Zike Virus NS2B-NS3 Protease Inhibitors
This invention includes a novel high-throughput assay to identify orthosteric inhibitors blocking the Zika virus NS2B-NS3 protease. Pathogenic flaviviruses, including Zika, require the NS2B-NS3 protease for viral replication. There is currently an unmet need for specific antiviral therapeutics against the Zika virus. Preliminary screening using the...
Published: 7/25/2024   |   Inventor(s): Menghang Xia, Ruili Huang, Laura Kramer, Zhong Li, Hongmin Li
Keywords(s): Activity, Antiflaviviral, Compositions, PHARMACEUTICAL, VLXXXX, WIXXXX, WKXXXX, XHXXXX
Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, ResearchProducts > Research Equipment, Application > Research Materials
Gas-assisted dynamic co-extrusion
Unmet Need: Scalable and high-throughput fabrication of personalized medicines In order to avoid dosage errors and adverse drug reactions for people taking multiple medications for co-occurring diseases, personalized medicines was introduced. This offered treatment of a patient by manufacturing proper drugs at the appropriate dosage via additive manufacturing...
Published: 5/26/2023   |   Inventor(s): Kuen-Ren Chen
Keywords(s): 3D printing, Additive Manufacturing, drug, Pharmaceutical, Precision medicine
Category(s): Products, Technologies, Technologies > Health & Well-being > Medical Devices, Technologies > Health & Well-being > Pharmaceutical
Sustainable Dehydrocoupling and Hydrofunctionalization Methods for Preparing Aminosilanes, Polysilazane Coatings, and Silicones
Background Silicon nitride, silicon oxynitride, silicon carbonitride, and silicon dioxide films are used to protect the semiconducting regions of microprocessors, memory devices, and solar panels. These coatings are prepared by atomic layer deposition (ALD) or chemical vapor deposition (CVD) using aminosilanes, or by applying perhydropolysilazane solutions....
Published: 2/23/2023   |   Inventor(s): Ryan Trovitch, Anuja Sharma, Thu Thao Nguyen
Keywords(s): Catalysis, Chemicals, Electronics, Fabrication, Pharmaceutical, Polymer, Reagents, Small Molecule, Small Organic Molecules, Synthesis
Category(s): Bioanalytical Assays, Chemistries & Devices, Physical Science, Semiconductors, Materials & Processes
Microreactor Array Instrument/Platform
High throughput parallel assays are needed to effectively identify and study biomolecules and their activity. Typically it takes a large number of repeated assays to get statistically significant data for studying biomolecules. However, fewer assays would be needed to get statistically meaningful results if the data were of higher quality. Because of...
Published: 2/23/2023   |   Inventor(s): Peter Wiktor
Keywords(s): Array Techs - Micro, Nano, Gen,Proteomic, Bioassay, Bio-Technology, Detection, Diagnostics, Diffusion, DNA nanotechnology, Drug Discovery, Drug Screening, Drug Target Identification, ELISA, Genomics, Proteomics, Health Monitoring, High Throughput Sensors, Immunology, In situ, In Vitro, Instrumentation, Liquid Handling and Dispensing, MicroArray, Microbiology, Micro-Fluidics, Microreactor, Molecular Diagnostics, Nucleic Acid, Personalized medicine, Pharmaceutical, Polymerase Chain Reaction (PCR), Protein, Protein Assays
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools
Methods and Compositions for Prevention and Treatment of Apicomplexan Infections
Unmet Need: Effective treatment options to combat Apicomplexan parasitic infectionsDiseases caused by apicomplexan parasites, such as cryptosporidiosis and malaria are among the most devastating to humans and their domestic animals. Ongoing discovery and development of new drugs to treat these diseases is a medical and veterinary imperative. For example,...
Published: 5/25/2023   |   Inventor(s): Roberta O'Connor, Eric Schmidt
Keywords(s): Animal Research, anti-parasitic drugs, Global Human and Animal Health, Natural products, Pharmaceutical, Therapeutics, Veterinary
Category(s): Technologies > Health & Well-being > Veterinary, Technologies > Health & Well-being > Pharmaceutical, Technologies > Health & Well-being > Biotechnology
Small molecular inhibitors of RAD51 recombinase and methods thereof
PAGE TITLE Overview PAGE SUMMARY Drexel researchers have developed small molecule therapeutics overcoming drug resistance mechanisms in certain types of ovarian and breast cancers. These compounds are specific inhibitors of human RAD51, a protein that plays a critical role in the repair of DNA double-strand breaks (DSB) and inter-strand...
Published: 7/12/2024   |   Inventor(s): Alexander Mazin, Fei Huang
Keywords(s): Cancer therapeutic, Pharmaceutical
Category(s): Pharmaceuticals & Therapeutics, Pharmaceuticals & Therapeutics > Pharma: Oncology
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