Search Results - alfred+lewin

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Adeno-Associated Virus-Based Serpin Delivery for Use as Anti-Inflammatory Gene Therapy
Recombinant Adeno-Associated Virus (rAAV) Vector Expressing Serine Proteinase Inhibitor 1 for Inhibiting Multiple Targets in the Inflammatory Cascade This recombinant AAV vector encoding a serine proteinase inhibitor (Serp-1) downregulates inflammation by targeting and inhibiting human serine proteinase enzymes. Inflammatory disorders, including lupus,...
Published: 3/28/2025   |   Inventor(s): Alfred Lewin, Alexandra Lucas, Westley Reeves, Douglas McFadden, Cristhian Ildefonso, Sriram Ambadapadi
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Therapeutics
AAV Vector that Promotes Antioxidant Production for Treatment of Age-Related Macular Degeneration
Gene Therapy Requires Just One Intraocular Injection to Treat Eye Ailment Caused by Oxidative StressThis AAV gene therapy approach provides a one-time treatment to oxidative stress. Sustained oxidative stress can lead to a variety of pathophysiological diseases including age-related macular degeneration, diabetic retinopathy, and amyotrophic lateral...
Published: 12/22/2022   |   Inventor(s): Qiuhong Li, Christhian Ildefonso, Alfred Lewin
Keywords(s): Age Related Macular Degeneration, Alzheimer's Disease, Diabetic Retinopathy, Gene Therapy, Macular Degeneration, Retinal Degeneration, uveitis
Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Others
Small Peptide Expression System in Mammalian Cells
Treats Various Diseases Including Cancer, Neurodegenerative Disorders and DiabetesThis small peptide expression technique effectively expresses small peptides through gene delivery in mammalian cells providing promising targets for therapeutic interventions for many pathological conditions. The use of peptides as mainstream drug candidates has been...
Published: 6/27/2021   |   Inventor(s): William Hauswirth, Alfred Lewin, Qiuhong Li
Keywords(s): Cell penetrating peptide, expression vector, furin cleavage, Plasmid, rAAV, small peptide
Category(s): Technology Classifications > Research Tools > Therapeutics