Search Results - techpub+algolia+%3e+drug+discovery

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c‑Abl Modulators for Neurodegenerative Disease Treatment
Application Small‑molecule c‑Abl inhibitors designed to treat neurodegenerative diseases such as Parkinson’s and Alzheimer’s. Key Benefits Targets c‑Abl, a key regulator linked to neurodegeneration, oxidative stress, and loss of dopaminergic neurons. Provides new small‑molecule scaffolds with potential for improved safety profiles...
Published: 3/2/2026   |   Inventor(s): Thomas Kaiser, Zackery Dentmon, Christopher Dalloul, Dennis Liotta
Keywords(s): Drug Target Identification, Neurology and Pain Treatments, Rare and Orphan Disease Treatments, Small Molecule, Therapeutics
Category(s): TechPub Algolia > Drug Discovery
Precision Neo-Cysteine Molecular Glues to Restore Protein-Protein Interactions in Disease
Application Molecular glues designed to selectively bind mutated neo-cysteine residues and restore disease-disrupted protein–protein interactions (PPIs), offering a precision therapeutic approach for conditions such as cancer where loss or weakening of critical protein interactions drives tumor growth and progression. Key Benefits Provides...
Published: 3/2/2026   |   Inventor(s): Xiulei Mo, Haian Fu
Keywords(s): Oncology Treatments, Personalized Medicine, Protein and Peptide Therapeutics, Therapeutics
Category(s): TechPub Algolia > Drug Discovery
Small Molecule Inhibitors Targeting OTUD4-CD73 Interaction for Immune-Cold Tumors
Application This technology introduces small molecule inhibitors, ST80 and Z22, to disrupt the protein-protein interaction (PPI) between OTUD4 and CD73. These inhibitors enhance tumor immunogenicity by reducing CD73 stabilization, improving the immune response in triple-negative breast cancer (TNBC) and other immune-cold tumors. Key Benefits ST80...
Published: 1/20/2026   |   Inventor(s): Yong Wan, Yueming Zhu, Ivet Bahar, Anupam Banerjee, Jiyoung Lee
Keywords(s): Drug Target Identification, Immunotherapy, Oncology Treatments, Small Molecule, Therapeutics
Category(s): TechPub Algolia > Drug Discovery
Molecules Targeting Inflammatory Signaling
Application A group of small molecules for treating central and peripheral diseases associated with inflammation. Key Benefits Applicable to a wide variety of central nervous system and peripheral diseases. Can bypass side effects of existing therapeutics targeting similar inflammatory pathways. High target selectivity and aqueous solubility. Capability...
Published: 3/10/2026   |   Inventor(s): Raymond (Ray) Dingledine, Radhika Amaradhi, Shabber Mohammed, Thota Ganesh
Keywords(s): Immunology and Inflammation Treatments, Neurology and Pain Treatments, Oncology Treatments, Small Molecule, Women's Health
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease. Key Benefits Improved cellular uptake and protein suppression using antisense oligos. Longer ASO half-life compared to other ASO delivery methods. Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 3/10/2026   |   Inventor(s): Khalid Salaita, Radhika Sharma
Keywords(s): Biomaterials, Cardiology and Vascular Devices, Chemistry, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery, TechPub Algolia > Micro and Nanotechnology
Advancing Lymphatic Endothelial Cell Generation from iPSCs
Application The developed protocol offers a reproducible and scalable method for generating lymphatic endothelial cells (LECs) from induced pluripotent stem cells (iPSCs), addressing critical challenges in the field of lymphatic-related therapies. Key Benefits Reproducible and scalable protocol for generating LECs from iPSCs. Utilizes specific...
Published: 10/3/2025   |   Inventor(s): Katherine Hekman, Katherine Owsiany
Keywords(s): Cell Therapy, Production Methods
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery
Next Generation L-Asparaginase Cancer Therapeutics
Application A humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers. Key Benefits Human‑aligned variants may reduce immunogenicity and systemic toxicity compared to current FDA‑approved asparaginase drugs. Opportunity to improve treatment outcomes by minimizing the severe hypersensitivity reactions...
Published: 3/10/2026   |   Inventor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
Keywords(s): Oncology Treatments, Pediatrics, Platform
Category(s): TechPub Algolia > Drug Discovery
Small Molecules for Cardioprotection
Application A small molecule showing cardioprotection from drug-induced and alcohol-induced cytotoxicity. Key Benefits Demonstrates broad impact with cardioprotective effects against multiple cardiotoxic agents, including alcohol and chemotherapeutic drugs like doxorubicin and bortezomib. Does not interfere with the proteasome inhibition activity...
Published: 3/11/2026   |   Inventor(s): Chunhui Xu, Antonio Rampoldi, Yuhong Du
Keywords(s): Cardiology and Vascular Devices, Screening Assays, Small Molecule
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery
ONC201 for the Treatment of Vascular Aneurysms
Application A repurposed therapeutic for the preventative and treatment of aneurysms. Key Benefits A repurposed cancer drug that targets cells known to be damaged during the progression of an aneurysm. The drug has been tested within an animal model of aortic aneurysms, where it prevented the severe complications of the disease and protected the...
Published: 1/20/2026   |   Inventor(s): Alejandra Maria San Martin
Keywords(s): Cardiology and Vascular Devices, Repurposed Drug
Category(s): TechPub Algolia > Drug Discovery
Small Molecules for Treating Cystic Fibrosis
ApplicationSmall molecule compounds to potentiate most common type of CFTR mutation in cystic fibrosis patients.Key BenefitsPotentiates ΔF508-hCFTR mutation, addressing more than 60 percent of CF patients. Market SummaryCystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and ion channel that malfunctions in the genetic...
Published: 2/13/2025   |   Inventor(s): Nael McCarty, Guiying Cui, Hanoch Senderowitz, Netaly Khazanov
Keywords(s): Rare and Orphan Disease Treatments, Respiratory Treatments, Small Molecule
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery
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