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Search Results - muxiang+zhou
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Repurposing a Potent MDM2 Inhibitor for Leukemia Treatment
Application VERU-111, also known as sabizabulin, is a potent microtubule inhibitor and, notably, an MDM2 inhibitor. This repurposed compound demonstrates remarkable efficacy in the treatment of Acute Myeloid Leukemia (AML). Key Benefits Unique dual-action functionality as a microtubule and MDM2 inhibitor. Successful inhibition of MDM2, an oncogene...
Published: 8/22/2024
|
Inventor(s):
Deborah DeRyckere
,
Muxiang Zhou
,
Lu Bing Gu
,
Douglas Graham
,
Tao Liu
Keywords(s):
Cell Line
,
Hematology/Blood Products
,
Oncology
,
Repurposed Drug
Category(s):
TechPub Algolia > Drug Discovery
Whole transcriptome start site sequencing (WTSS-seq) method
Unmet Need: Effective methods for genetic profilingRNA contributes significantly to the complexity of information transfer from genome to phenome. Alternative transcripts have been considered as biomarkers for improved early diagnosis of diseases, and as targets for designing novel treatment options. Recent studies have revealed that the transcriptome...
Published: 10/27/2021
|
Inventor(s):
Zhihua Jiang
,
Jennifer Michal
,
Xiang Zhou
Keywords(s):
Biotechnology
,
Diagnostics
,
High throughput
,
Tool
Category(s):
Health & Well-being > Biotechnology
,
Health & Well-being > Health-IT
Pre-B Acute Lymphoblastic Leukemia Cell Line EU-4
Application Cancer cell line derived from a pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia with myeloid phenotype. Key Benefits Does not express p53 and expresses wild-type MDM2. Expresses wild-type Bax, over-expresses Bcl-xl, and does not express Bcl-2. Can be used as a tool for gene transfection assays in...
Published: 7/30/2024
|
Inventor(s):
Muxiang Zhou
,
Lu Bing Gu
Keywords(s):
Cell Line
,
Oncology
Category(s):
TechPub Algolia > Research Tools
Early Pre-B Acute Lymphoblastic Leukemia Cell Line EU-1
Application Cancer cell line derived from a relapsed pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia. Key Benefits Well-characterized continuous leukemia-lymphoma cell line. Expresses wild-type p53 and over-expresses MDM2 oncoprotein. Expresses wild-type Bcl-2, Bcl-xl, and Bax. Technical Summary p53 is...
Published: 7/30/2024
|
Inventor(s):
Muxiang Zhou
,
Lu Bing Gu
Keywords(s):
Cell Line
,
Oncology
Category(s):
TechPub Algolia > Research Tools
Early Pre-B Acute Lymphoblastic Leukemia Cell Line EU-6
Application Cancer cell line derived from a relapsed pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia. Key Benefits Well-characterized to have a point mutation of the p53 gene at codon 273. Expresses wild-type Bax, Bcl-xl, and Bcl-2. Well used tool for p53 studies in leukemia. Technical Summary p53 is a tumor...
Published: 7/30/2024
|
Inventor(s):
Muxiang Zhou
,
Lu Bing Gu
Keywords(s):
Cell Line
,
Oncology
Category(s):
TechPub Algolia > Research Tools