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Search Results - repurposed+drug
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Repurposing a Potent MDM2 Inhibitor for Leukemia Treatment
Application VERU-111, also known as sabizabulin, is a potent microtubule inhibitor and, notably, an MDM2 inhibitor. This repurposed compound demonstrates remarkable efficacy in the treatment of Acute Myeloid Leukemia (AML). Key Benefits Unique dual-action functionality as a microtubule and MDM2 inhibitor. Successful inhibition of MDM2, an oncogene...
Published: 12/4/2024
|
Inventor(s):
Deborah DeRyckere
,
Muxiang Zhou
,
Lu Bing Gu
,
Douglas Graham
,
Tao Liu
Keywords(s):
Cell Line
,
Hematology/Blood Products
,
Oncology
,
Repurposed Drug
Category(s):
TechPub Algolia > Drug Discovery
ONC201 for the Treatment of Vascular Aneurysms
Application A repurposed therapeutic for the preventative and treatment of aneurysms. Key Benefits A repurposed cancer drug that targets cells known to be damaged during the progression of an aneurysm. The drug has been tested within an animal model of aortic aneurysms, where it prevented the severe complications of the disease and protected the...
Published: 11/20/2024
|
Inventor(s):
Alejandra Maria San Martin
Keywords(s):
Cardiovascular
,
Repurposed Drug
Category(s):
TechPub Algolia > Drug Discovery
Therapeutic to Treat Age-Dependent Idiopathic Pulmonary Fibrosis
Application Therapeutic for treating age-associated lung fibrosis. Key Benefits Tecfidera (dimethyl fumarate - DMF) is an FDA approved therapy to treat multiple sclerosis via oral administration. A novel formulation for inhaled delivery demonstrated efficacy for a new indication: Idiopathic Pulmonary Fibrosis (IPF), where it promotes the reversal...
Published: 11/20/2024
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Inventor(s):
Louise Hecker
,
Kosuke Kato
,
Priyadarshini Muralidharan
,
Heidi Mansour
Keywords(s):
Repurposed Drug
,
Respiratory
Category(s):
TechPub Algolia > Therapeutics
A Predictive Marker and Treatment to Sensitize Multiple Myeloma Patients to Venetoclax (ABT-199)
Application A marker that predicts Venetoclax (ABT-199) sensitivity that can also be targeted with a drug to help multiple myeloma patients. Key Benefits Marker that predicts if venetoclax will be an effective treatment in multiple myeloma patients. A drug that targets venetoclax resistant multiple myeloma cells to improve treatment in patients. Market...
Published: 7/30/2024
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Inventor(s):
Malathy (mala) Shanmugam
,
Richa Bajpai
Keywords(s):
Biologic
,
Biomarker
,
Oncology
,
Repurposed Drug
,
Target
Category(s):
TechPub Algolia > Diagnostics
Repurposed Treatment for Cocaine Use Disorder
Application
Repurposed drug
for transcriptomic-driven treatment of cocaine use disorder. Key Benefits FDA-approved drug. Outperformed current targets undergoing clinical trials for CUD at the mRNA level. Market Summary Cocaine abuse is associated with substantial morbidity and mortality, and there are no approved medications for the treatment...
Published: 10/17/2024
|
Inventor(s):
Rohan Palmer
,
Spencer Huggett
Keywords(s):
Neuroscience/Pain
,
Repurposed Drug
Category(s):
TechPub Algolia > Therapeutics
Drug Combination to Treat Lung Cancer Metastasis
Application Combination product co-targeting PDH and GLUT1 to inhibit lung cancer metastasis. Key Benefits Combination of drugs exhibits greater synergism in cancer cell lines (H1299, 4T1, H1792). Has potential to prevent metastasis in a variety of cancers. Decreases both cell viability and invasive area.
Repurposed drug
s. Market Summary Metastatic...
Published: 7/30/2024
|
Inventor(s):
Malathy (mala) Shanmugam
,
Adam Marcus
Keywords(s):
Oncology
,
Repurposed Drug
,
Small Molecule
Category(s):
TechPub Algolia > Therapeutics
HDAC Inhibitors for Managing Vascular Conditions and Diabetic Peripheral Neuropathies
Application Treatment of diabetic neuropathy using epigenetic modulators, histone deacetylase inhibitors (HDACis), to ameliorate or prevent vascular conditions and neuropathic pains by nerve damages. Key Benefits Reverses or protects against diabetes-induced nerve damages by direct injection of HDACi. Relatively low regulatory risk because many...
Published: 11/20/2024
|
Inventor(s):
Young-Sup Yoon
,
Ji Woong (Jay) Han
,
Hyunsuk Shim
Keywords(s):
Cell/Gene Therapy
,
Endocrinology
,
Metabolic Diseases
,
Repurposed Drug
,
Small Molecule
Category(s):
TechPub Algolia > Therapeutics
Therapeutic Compounds Inhibiting DUSP5 and DUSP6 for Cardiomyocyte Proliferation and Cardiac Regeneration
Application Therapeutics using siRNAs and small molecules to treat congenital heart defect and myocardial injuries. Key Benefits Reactivates cardiomyocyte (CM) cell replication, allowing regeneration of heart muscle after cardiac injuries. Therapeutic compounds may be administered for transient regeneration/repair of heart muscle after cardiac...
Published: 7/30/2024
|
Inventor(s):
Ahsan Husain
,
Nawazish Naqvi
Keywords(s):
Biologic
,
Cardiovascular
,
Repurposed Drug
,
Small Molecule
Category(s):
TechPub Algolia > Therapeutics
Targeted Anti-Cancer Nanoparticle Therapy
Application A drug-carrying nanoparticle that selectively targets cancer cells. Key Benefits Incorporates an already proven anti-cancer therapeutic. Increases deliverability. Targets cancer cells. Market Summary Tris DBA palladium has been shown to have anti-cancer activity against melanoma and pancreatic cancer. However, Tris DBA has not...
Published: 10/28/2024
|
Inventor(s):
Jack Arbiser
,
Lily Yang
Keywords(s):
Oncology
,
Repurposed Drug
Category(s):
TechPub Algolia > Therapeutics
,
TechPub Algolia > Micro and Nanotechnology
Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax. Key Benefits Co-therapy increases MM sensitivity to venetoclax treatment. Identifies patients who will respond to venetoclax therapy. Market Summary Multiple Myeloma (MM) is a cancer of plasma cells responsible for making antibody...
Published: 10/28/2024
|
Inventor(s):
Malathy (mala) Shanmugam
,
Richa Bajpai
Keywords(s):
Biologic
,
Biomarker
,
Oncology
,
Rare/Orphan Diseases
,
Repurposed Drug
,
Target
Category(s):
TechPub Algolia > Diagnostics
,
TechPub Algolia > Therapeutics
,
TechPub Algolia > Drug Discovery
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