Search Results - repurposed+drug

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Repurposing a Potent MDM2 Inhibitor for Leukemia Treatment
Application VERU-111, also known as sabizabulin, is a potent microtubule inhibitor and, notably, an MDM2 inhibitor. This repurposed compound demonstrates remarkable efficacy in the treatment of Acute Myeloid Leukemia (AML). Key Benefits Unique dual-action functionality as a microtubule and MDM2 inhibitor. Successful inhibition of MDM2, an oncogene...
Published: 8/22/2024   |   Inventor(s): Deborah DeRyckere, Muxiang Zhou, Lu Bing Gu, Douglas Graham, Tao Liu
Keywords(s): Cell Line, Hematology/Blood Products, Oncology, Repurposed Drug
Category(s): TechPub Algolia > Drug Discovery
Repurposing an FDA-Approved Drug for Treating Age-Associated Lung Fibrosis
Application New use of an FDA-approved therapeutic, diroximel fumarate (Vumerity), for treating Idiopathic Pulmonary Fibrosis. Key Benefits Novel use of an FDA-approved drug, diroximel fumarate - DRF (Vumerity), for treating age-dependent lung fibrosis. Lung-targeted inhaled delivery of DRF is effective for boosting lung antioxidant responses...
Published: 8/22/2024   |   Inventor(s): Louise Hecker, Kosuke Kato
Keywords(s): Repurposed Drug, Respiratory
Category(s): TechPub Algolia > Therapeutics
ONC201 for the Treatment of Vascular Aneurysms
Application A repurposed therapeutic for the preventative and treatment of aneurysms. Key Benefits A repurposed cancer drug that targets cells known to be damaged during the progression of an aneurysm. The drug has been tested within an animal model of aortic aneurysms, where it prevented the severe complications of the disease and protected the...
Published: 7/30/2024   |   Inventor(s): Alejandra Maria San Martin
Keywords(s): Cardiovascular, Repurposed Drug
Category(s): TechPub Algolia > Drug Discovery
Therapeutic to Treat Age-Dependent Idiopathic Pulmonary Fibrosis
Application Therapeutic for treating age-associated lung fibrosis. Key Benefits Tecfidera (dimethyl fumarate - DMF) is an FDA approved therapy to treat multiple sclerosis via oral administration. A novel formulation for inhaled delivery demonstrated efficacy for a new indication: Idiopathic Pulmonary Fibrosis (IPF), where it promotes the reversal...
Published: 8/22/2024   |   Inventor(s): Louise Hecker, Kosuke Kato, Priyadarshini Muralidharan, Heidi Mansour
Keywords(s): Repurposed Drug, Respiratory
Category(s): TechPub Algolia > Therapeutics
A Predictive Marker and Treatment to Sensitize Multiple Myeloma Patients to Venetoclax (ABT-199)
Application A marker that predicts Venetoclax (ABT-199) sensitivity that can also be targeted with a drug to help multiple myeloma patients. Key Benefits Marker that predicts if venetoclax will be an effective treatment in multiple myeloma patients. A drug that targets venetoclax resistant multiple myeloma cells to improve treatment in patients. Market...
Published: 7/30/2024   |   Inventor(s): Malathy (mala) Shanmugam, Richa Bajpai
Keywords(s): Biologic, Biomarker, Oncology, Repurposed Drug, Target
Category(s): TechPub Algolia > Diagnostics
Repurposed Treatment for Cocaine Use Disorder
Application Repurposed drug for transcriptomic-driven treatment of cocaine use disorder. Key Benefits FDA-approved drug. Outperformed current targets undergoing clinical trials for CUD at the mRNA level. Market Summary Cocaine abuse is associated with substantial morbidity and mortality, and there are no approved medications for the treatment...
Published: 8/22/2024   |   Inventor(s): Rohan Palmer, Spencer Huggett
Keywords(s): Neuroscience/Pain, Repurposed Drug
Category(s): TechPub Algolia > Therapeutics
Drug Combination to Treat Lung Cancer Metastasis
Application Combination product co-targeting PDH and GLUT1 to inhibit lung cancer metastasis. Key Benefits Combination of drugs exhibits greater synergism in cancer cell lines (H1299, 4T1, H1792). Has potential to prevent metastasis in a variety of cancers. Decreases both cell viability and invasive area. Repurposed drugs. Market Summary Metastatic...
Published: 7/30/2024   |   Inventor(s): Malathy (mala) Shanmugam, Adam Marcus
Keywords(s): Oncology, Repurposed Drug, Small Molecule
Category(s): TechPub Algolia > Therapeutics
HDAC Inhibitors for Managing Vascular Conditions and Diabetic Peripheral Neuropathies
Application Treatment of diabetic neuropathy using epigenetic modulators, histone deacetylase inhibitors (HDACis), to ameliorate or prevent vascular conditions and neuropathic pains by nerve damages. Key Benefits Reverses or protects against diabetes-induced nerve damages by direct injection of HDACi. Relatively low regulatory risk because many...
Published: 7/30/2024   |   Inventor(s): Young-Sup Yoon, Ji Woong (Jay) Han, Hyunsuk Shim
Keywords(s): Cell/Gene Therapy, Endocrinology, Metabolic Diseases, Repurposed Drug, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Therapeutic Compounds Inhibiting DUSP5 and DUSP6 for Cardiomyocyte Proliferation and Cardiac Regeneration
Application Therapeutics using siRNAs and small molecules to treat congenital heart defect and myocardial injuries. Key Benefits Reactivates cardiomyocyte (CM) cell replication, allowing regeneration of heart muscle after cardiac injuries. Therapeutic compounds may be administered for transient regeneration/repair of heart muscle after cardiac...
Published: 7/30/2024   |   Inventor(s): Ahsan Husain, Nawazish Naqvi
Keywords(s): Biologic, Cardiovascular, Repurposed Drug, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Small Molecules to Promote Bone Growth
Application Small molecule sclerostin-inhibitors to enhance the canonical Wnt pathways and promote BMP-induced osteoblast differentiation. Key Benefits Repurposing opportunities of FDA approved drugs. Lower cost compared to currently available monoclonal antibody or recombinant protein therapies. Stable compounds with established safety profiles...
Published: 8/22/2024   |   Inventor(s): Scott Boden, Steven Presciutti, Sreedhara Sangadala
Keywords(s): Musculoskeletal, Repurposed Drug, Small Molecule
Category(s): TechPub Algolia > Therapeutics
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