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Search Results - lu+bing+gu
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Repurposing a Potent MDM2 Inhibitor for Leukemia Treatment
Application VERU-111, also known as sabizabulin, is a potent microtubule inhibitor and, notably, an MDM2 inhibitor. This repurposed compound demonstrates remarkable efficacy in the treatment of Acute Myeloid Leukemia (AML). Key Benefits Unique dual-action functionality as a microtubule and MDM2 inhibitor. Successful inhibition of MDM2, an oncogene...
Published: 12/4/2024
|
Inventor(s):
Deborah DeRyckere
,
Muxiang Zhou
,
Lu Bing Gu
,
Douglas Graham
,
Tao Liu
Keywords(s):
Cell Line
,
Hematology/Blood Products
,
Oncology
,
Repurposed Drug
Category(s):
TechPub Algolia > Drug Discovery
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023
|
Inventor(s):
Jianfeng Cai
,
Shibo JIANG
,
Lu LU
,
Songyi XUE
,
Xinling WANG
,
Lei WANG
,
Wei XU
,
Shuai XIA
Keywords(s):
Drug Discovery
,
Immunology
Category(s):
Technology Classifications > Medical > Biotechnology
Network-Coded Multiple Access
[Licensing negotiation in progress] [Invitation for Expression of Interest - Deadline: 16 June 2016] Systems and methods include a first wireless local area network (WLAN) system that jointly exploit physical-layer network coding (PNC) and multi-user decoding (MUD) to boost system throughput. This multiple access mode is referred to as Network-Coded...
Published: 1/29/2024
|
Inventor(s):
Soung Chang Liew
,
Lu LU
,
Lizhao You
Keywords(s):
Network Coding
,
Wireless Local Area Network
Category(s):
Information and Communications Technology
Pre-B Acute Lymphoblastic Leukemia Cell Line EU-4
Application Cancer cell line derived from a pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia with myeloid phenotype. Key Benefits Does not express p53 and expresses wild-type MDM2. Expresses wild-type Bax, over-expresses Bcl-xl, and does not express Bcl-2. Can be used as a tool for gene transfection assays in...
Published: 11/20/2024
|
Inventor(s):
Muxiang Zhou
,
Lu Bing Gu
Keywords(s):
Cell Line
,
Oncology
Category(s):
TechPub Algolia > Research Tools
Early Pre-B Acute Lymphoblastic Leukemia Cell Line EU-1
Application Cancer cell line derived from a relapsed pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia. Key Benefits Well-characterized continuous leukemia-lymphoma cell line. Expresses wild-type p53 and over-expresses MDM2 oncoprotein. Expresses wild-type Bcl-2, Bcl-xl, and Bax. Technical Summary p53 is...
Published: 11/20/2024
|
Inventor(s):
Muxiang Zhou
,
Lu Bing Gu
Keywords(s):
Cell Line
,
Oncology
Category(s):
TechPub Algolia > Research Tools
Early Pre-B Acute Lymphoblastic Leukemia Cell Line EU-6
Application Cancer cell line derived from a relapsed pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia. Key Benefits Well-characterized to have a point mutation of the p53 gene at codon 273. Expresses wild-type Bax, Bcl-xl, and Bcl-2. Well used tool for p53 studies in leukemia. Technical Summary p53 is a tumor...
Published: 11/20/2024
|
Inventor(s):
Muxiang Zhou
,
Lu Bing Gu
Keywords(s):
Cell Line
,
Oncology
Category(s):
TechPub Algolia > Research Tools