Search Results - technology+classifications+%3e+vaccines

19 Results Sort By:
Small Molecules That Expose HIV Env Sites To Trigger Targeted Immune Killing
This technology uses small molecules to bind HIV Env on infected cells, expose hidden sites, and trigger ADCC, enabling the immune system to kill cells that current therapies cannot reach. By improving antibody recognition and reducing infectious virus production, it provides a complementary approach that directly targets infected cells rather than...
Published: 12/1/2025   |   Inventor(s): Amos Smith, Melissa Grenier-Davies, Andres Finzi, Jean-Philippe Chapleau, Shilei Ding
Keywords(s): HIV/AIDS
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Peptides For Solid Cancer Tumor Immunotherapy Treatment
Short, multivalent peptide antagonists to block macrophage immune-receptor SIRPα, promoting cancer cell phagocytosis. Problem: Modern cancer cell immunotherapies incorporate immune checkpoint blockade mechanisms, where prominent therapies target functionally suppressed immune cells in tumor microenvironments. Relieving this suppression allows...
Published: 9/17/2025   |   Inventor(s): Dennis Discher, AbdelAziz Jalil
Keywords(s): Cell Therapy, Immunology, Oncology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Methods and Sequences for mRNA and Other HIV Vaccine Development
Unique sequences eliciting broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) that could be used to develop effective mRNA-based and other types of HIV vaccine. Problem: Despite decades of research, there is currently no vaccine to prevent HIV infection. A major goal of HIV vaccine programs is to generate bNAbs, which...
Published: 8/1/2025   |   Inventor(s): George Shaw, Edward (Ted) Kreider, Beatrice Hahn, Ashwin Skelly, Hui Li, Drew Weissman
Keywords(s): Bioengineering, HIV/AIDS, Immunology, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Vaccines
Lipid Nanoparticles That Specifically Target The Lungs
Lung-targeting lipid nanoparticles allowing organ specific mRNA delivery for gene therapy applications. Problem: Gene therapy via mRNA delivery allows the rapid generation of therapeutics and vaccines for a wide range of applications. However, mRNA is especially vulnerable to degradation in the body, necessitating packaging within lipid nanoparticles....
Published: 11/26/2025   |   Inventor(s): Michael Mitchell, Lulu Xue
Keywords(s): Bioengineering, COVID-19, Gene Therapy, Infectious Disease, Pulmonary
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Targeted Organ or Multiple Organ Delivery of mRNA with Ionizable Amphiphilic Janus Dendrimers
A library of easily synthesized ionizable amphiphilic Janus dendrimer (IAJD) compounds that deliver mRNA either to targeted organs or multiple organs, depending on the IAJD design. Problem: Four-component lipid nanoparticles (LNPs) are the benchmark synthetic vector for the delivery of mRNA. Despite their high biosafety, low toxicity, and immunogenicity,...
Published: 9/12/2025   |   Inventor(s): Virgil Percec, Drew Weissman, Juncheng (Luke) Lu, Elena Atochina-Vasserman, Devendra Maurya, Dipankar Sahoo
Keywords(s): Drug Delivery, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Vaccines
Universal cancer vaccine targeting tumor vasculature
A DNA vaccine targeting tumor endothelial marker 1 (TEM1) that allows to prevent and delay tumor progression without adverse effect on physiologic angiogenesis Technology Overview: Immunization against antigens specifically expressed on tumor vasculature is a very attractive immunotherapy options due to its ability to prevent solid tumor growth....
Published: 3/19/2025   |   Inventor(s): Andrea Facciabene, George Coukos
Keywords(s): Oncology
Category(s): Technology Classifications > Vaccines
Immune Modulator Encoded Lipid Nanoparticle Formulation Improves T Cell Response to Vaccines
Researchers developed an LNP-mRNA-based vaccine that encodes different cytokine mRNAs, as a method to enhance CD8+ T cell responses and memory formation. Problem: Lipid nanoparticles (LNPs) are an emerging technique to deliver mRNA in vivo more efficiently. While recent progress in mRNA technology has allowed the rapid development of SARS-COV2 vaccines,...
Published: 9/8/2025   |   Inventor(s): Christopher Hunter, Drew Weissman, Mohamad-Gabriel Alameh, Emily Aunins, Anthony Phan
Keywords(s): Bioengineering, Drug Delivery, Immunology, Immunoncology, Immunotherapy, Infectious Disease, Nanotechnology
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Modified Antimicrobial Peptides For Enhanced Antibiotic Properties
Modified antimicrobial peptides with protein sequences for augmenting antimicrobial and antibiofilm properties. Problem: Antibiotic resistant bacteria are becoming more prevalent, while antibiotic innovation has slowed. Novel antimicrobial agents are needed to treat the 35,000 annual deaths from antibiotic resistant infections. While antimicrobial...
Published: 9/16/2025   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Octavio Franco
Keywords(s): Bioengineering, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Direct and Effective Method To Reverse The Effects of Fragile X Syndrome
A method of treating Fragile X syndrome by correcting the abnormal DNA clusters causing the characteristic symptoms. Problem: Fragile X syndrome (FXS) affects approximately 1 in 4,000 males and 1 in 8,000 females and is characterized by symptoms such as: Inherited Intellectual Disability Anxiety Attention Deficit Disorder (ADD) Skin, Ovaries...
Published: 3/8/2024   |   Inventor(s): Jennifer Phillips-Cremins, Linda Zhou, Chunmin GE
Keywords(s): Bioengineering, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Neurology
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Modified Lipid Nanoparticle Formulations with Improved Therapeutic Delivery to the Bone Microenvironment In-vivo
A library of bi-phosphonate ionizable lipids and LNP formulations to facilitate mRNA delivery to the bone microenvironment. Problem: The increasing prevalence of skeletal diseases such as osteoporosis, osteoarthritis and bone cancer have motivated efforts to target the bone microenvironment therapeutically. However, therapeutic agents must overcome...
Published: 11/26/2025   |   Inventor(s): Michael Mitchell, Lulu Xue
Keywords(s): Drug Delivery, Drug Target, Nanotechnology, Orthopedics, Platform Technology, Regenerative Medicine
Category(s): Technology Classifications > Vaccines, Technology Classifications > Therapeutics, Technology Classifications > Research Tools & Reagents
1 2