Search Results - virgil+percec

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Targeted Organ or Multiple Organ Delivery of mRNA with Ionizable Amphiphilic Janus Dendrimers
A library of easily synthesized ionizable amphiphilic Janus dendrimer (IAJD) compounds that deliver mRNA either to targeted organs or multiple organs, depending on the IAJD design. Problem: Four-component lipid nanoparticles (LNPs) are the benchmark synthetic vector for the delivery of mRNA. Despite their high biosafety, low toxicity, and immunogenicity,...
Published: 7/23/2024   |   Inventor(s): Virgil Percec, Drew Weissman, Juncheng (Luke) Lu, Elena Atochina-Vasserman, Devendra Maurya, Dipankar Sahoo
Keywords(s): Drug Delivery, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Vaccines
Stable Biological Membrane Mimetic For Enhanced Protein Recruitment
Synthetic biological alternative to natural lipids for conjugation with nitrilotriacetic acid (NTA) for enhanced His-tagged protein interaction and long-term stability. Problem: Biomimetic lipid vesicles, such as liposomes, have multiple biotechnology and drug delivery applications as their lipid bilayer innately interacts with natural cell membranes....
Published: 10/16/2023   |   Inventor(s): Virgil Percec, Qi Xiao, Matthew Good
Keywords(s): Bioengineering, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
Synthesis of arylboronate esters and biaryl compounds
Technology Overview: Aryl boronate esters and biaryls are of interest for certain pharmaceutical and electronic material applications. Penn scientists have developed a chemical methodology for the sequential Ni-catalyzed borylation with a novel in-situ prepared reagent and Ni-catalyzed cross-coupling to form biaryls. This process is useful for the...
Published: 10/16/2023   |   Inventor(s): Virgil Percec, Brad Rosen, Christopher Wilson, Daniela Wilson
Keywords(s):  
Category(s): Technology Classifications > Chemical Processes and Synthesis