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Fermentation Membrane Bioreactor for Biomanufacturing
Advantages Enables continuous, high-yield biomanufacturing beyond batch limitations Delivers real-time product extraction without interrupting fermentation Lowers operating costs by using waste-derived and alternative feedstocks Scales easily with automated control, ensuring consistent product quality Summary Traditional fermentation systems...
Published: 2/19/2026   |   Inventor(s): Daniel Yeh, Luke Roberson, Jason Fischer, Daniella Saetta, Alexandra Smith
Keywords(s): Biotechnology, Chemistry and Chemical Engineering, Energy Engineering, Renewable Energy
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Engineering > Chemical Engineering, Technology Classifications > Engineering > Manufacturing, Technology Classifications > Energy & Environment
Anti C. difficile Recurrence Vaccine Targeting Spore Colonization
Advantages Targets spore colonization, the root cause of CDI recurrence Broad coverage across diverse C. difficile strains Demonstrated protection in mice (reduced disease severity, toxins, and spore burden) Flexible delivery as injectable protein or oral L. lactis, enabling systemic + gut‑level immunity Summary Clostridioides difficile remains...
Published: 2/17/2026   |   Inventor(s): Xingmin Sun, Lubem Agbendeh, Soumyadeep Chakraborty
Keywords(s): Infectious Diseases, Vaccines
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Therapeutics
Novel Therapy to Prevent Kidney Transplant Rejection
Advantages First-in-class mechanism: Only known PPP1R3G/PP1γ inhibitor—differentiated from all RIPK1/RIPK3 competitors Upstream targeting: Acts before RIPK1 activation for potentially improved selectivity Validated efficacy: Demonstrated reduction in necroptosis markers (p-RIP1, p-RIP3, p-MLKL) Large unmet need: No approved DGF prevention...
Published: 2/11/2026   |   Inventor(s): Lei Wang, Zhigao Wang, Jianfeng Cai
Keywords(s): Organ Transplantation, Renal / Kidney
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Chemistry, Technology Classifications > Medical > Therapeutics
Exogenous Acetate Formulations for Treating Alcohol Use Disorder and Withdrawal
Advantages Mechanistic Innovation: stabilizes brain energy metabolism and modulates adenosine signaling mechanisms not targeted by current addiction therapies. Targeted Brain Delivery: formulations enable effective acetate transport across the blood-brain barrier, (BBB) Controlled and sustained release Versatile Administration Routes: compatible...
Published: 9/30/2025   |   Inventor(s): Dominic D'Agostino
Keywords(s): Neuroscience, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience
Novel Heart Failure Therapy: Farnesyltransferase Inhibition Targets Protein Aggregation in Cardiomyocytes
Advantages First-in-Class Mechanism: Targets a novel pathway—protein farnesylation—for heart failure treatment. Broad Therapeutic Potential: Effective in both HFrEF and HFpEF, addressing a major unmet need. Tested in multiple preclinical models: Danon disease cardiomyopathy (genetic model); HFpEF (diet-induced and hypertensive models);...
Published: 11/7/2025   |   Inventor(s): Kunhua Song, Congwu Chi, Amanda Conniff
Keywords(s): Cardiovascular Diseases, Drug Repurpose, Medical Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Chemistry
Cell Wall Protein 6 (Cwp6) as a Vaccine Component Against Clostridioides difficile Infection
Advantages Broader protection: targets bacterial colonization in addition to toxins A (TcdA) and B (TcdB) Applicability across different C. diff strains: Cwp6 is conserved across various C.diff ribotypes and toxinotypes Dual immune response: administration of Cwp6 with alum adjuvant elicits both systemic and IgG and mucosal IgA antibody responses Summary C.difficile...
Published: 9/29/2025   |   Inventor(s): Xingmin Sun, Lubem Agbendeh
Keywords(s):  
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases
A Novel Immunomodulatory Strategy for Treating Heart Failure in Aging Populations
Advantages Novel Mechanism of Action: Targets the Th17/IL17A signaling axis Validated Target: IL17A is already clinically validated in other inflammatory diseases (e.g., psoriasis, psoriatic arthritis), with FDA-approved therapies like secukinumab Strong Preclinical POC: transcriptomic, histological, and functional cardiac assessments showing reversal...
Published: 10/14/2025   |   Inventor(s): Wanling Xuan, Srinivas Tipparaju
Keywords(s): Cardiological Diseases Treatment, Cardiovascular Diseases, Drug Discovery
Category(s): zzCardiology, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Methionine Sulfoxide Reductase A (MsrA) Gene Therapy for Retinal Degeneration
Advantaages Targeted Protection Against Oxidative Stress Dual-Vector Delivery System (AAV and Lenti) Simple and scalable plasmid design for efficient production Suitable for major ophthalmology indications: Age-related macular degeneration (AMD), Retinitis pigmentosa, other oxidative stress-related retinal degenerations Summary Oxidative stress...
Published: 10/14/2025   |   Inventor(s): Manas Biswal
Keywords(s): Ophthalmology, Pharmaceuticals
Category(s): Technology Classifications, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
FLR: A Triple-Target Fusion Vaccine Candidate Against Clostridioides difficile
Advantages Multi-Antigen Targeting for Broad Protection: targets three distinct virulence factors (FliC, LP2, RBD2) simultaneously Targeting Hypervirulent Strain Pathogenesis Significant protection from infection and weight loss Reduced fecal toxin and spore levels Summary Clostridioides difficile (C. difficile) is a bacterium that colonizes...
Published: 9/29/2025   |   Inventor(s): Xingmin Sun
Keywords(s): Infectious Diseases Treatment, Vaccines
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering
Cell Culture Dishes with Dynamically Reconfigurable Surface Textures for Cell Expansion and Harvesting
Advantages Enzyme-free individual cell harvesting: avoids cellular damage, preserving cell viability and surface receptors Single-cell resolution: Releases dispersed individual cells rather than large confluent sheets, which is ideal for clonal assays Rapid (<1 min), mild stimulus-triggered detachment: triggers detachment via a brief temperature...
Published: 7/24/2025   |   Inventor(s): Nathan Gallant, Ryan Toomey, Michael Cross
Keywords(s):  
Category(s): Technology Classifications > Chemistry > Polymers, Technology Classifications > Medical > Biomaterials, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Research Tools/Copyright
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