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Antibacterial-Modified Comet Assay for the Study of Genome Integrity in Bacterial Pathogenesis

Advantages: The modified comet assay delivers consistent, reproducible results, ensuring reliable data for bacterial pathogenesis and DNA damage/repair studies A cost-effective and user-friendly antimicrobial peptide, making the modified comet assay an economical solution The method is versatile, applicable to bacteria, mammalian cells, microbiome,...

Published: 12/16/2024 | Inventor(s): Marcus Cooke, Haley Lockhart

Keywords(s):

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Medical Diagnostics

Novel Therapeutic Target to Promoting Cardiomyocyte Proliferation and Enhance Cardiac Regeneration for Myocardial Injury and Disease

Advantages: Identification of MRPS5 as a Therapeutic Target: Reduction of MRPS5 expression stimulates cardiomyocyte proliferation and enhances heart function Discovery of the MRPS5 signaling axis: Decreased MRPS5 enhances ATF4 and Knl1, which promote cardiomyocyte, boosting cardiac recovery after myocardial injury Improved Survival and Cardiac...

Published: 11/22/2024 | Inventor(s): Da-Zhi Wang, John Mably

Keywords(s): Biotechnology, Cardiological Diseases Treatment, Cell & Tissue Culture & Engineering, Medical Diagnostics, Pharmaceuticals

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Pharmaceuticals

Targeting mTOR-Related Autophagy Dysfunction to Treat Age-Related Hearing Loss with Rapamycin and Its Derivatives

Advantages: Novel Application of FDA approved drugs, rapamycin and its derivatives, for treating age-related hearing loss (ARHL). Targeting mTOR alleviates oxidative stress and inflammation in the cochlea, enhancing cellular health and resilience to age-related damage. Potential to Reverse or Delay Age-related hearing loss (ARHL) in patients. Summary: Age-related...

Published: 11/5/2024 | Inventor(s): Robert Frisina, Xiaohua Zhu, Bo Ding, Xiaoxia Zhu

Keywords(s): Pharmaceuticals, Therapeutics

Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices

Sensitive and Robust Biosensing Using Plasmonic Enhancement of Fluorescence by Rapid Thermal Annealed Silver Nanostructures

Advantages: Enhances cancer biomarker sensitivity Scalable production methods Enables low-concentration detection Ideal for portable diagnostics Summary: In cancer diagnostics, a major challenge is the detection of biomarkers at extremely low concentrations, particularly at the nanogram per milliliter (ng/ml) level, which is crucial for...

Published: 9/17/2024 | Inventor(s): Shuangming Li, Venkat Bhethanabotla

Keywords(s): Biomarker, Cancer Diagnostics

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Medical Diagnostics

Human Adipose-Derived Stem Cell Exosomes’ Packaging for Use at Room Temperature

Advantages: Promotes wound healing and supports positive long-term outcomes Reduces oxidative stress in human dermal fibroblasts (HDF) by exposing them to a composition containing adipose stem cell-derived exosomes Promising solution specifically tailored for penetrating wounds such as during military combat Summary: Penetrating injuries...

Published: 9/17/2024 | Inventor(s): Niketa Patel

Keywords(s): Wound and Tissue Healing

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Therapeutics

A Vaccine Technology for Preventing Clostridioides difficile Infection Using Cell Wall Protein 2 (CWP 2)

Advantages: A recombinant Cwp2 protein that induces strong IgG and IgA antibody response in animal models. Decrease levels of C. difficile spores and toxins in feces and decrease mortality rates in immunized mice. Anti-Cwp2 antibodies delay the binding of C. difficile vegetative cells to human gut epithelial cells and prevent bacterial colonization....

Published: 9/17/2024 | Inventor(s): Xingmin Sun, Shaohui Wang

Keywords(s): Vaccines

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Medical > Biotechnology

Modulating Molecular Chaperone DnaJB6b as a Novel Method to Regulate Tau Seeding and Propagation

Advantages: Semi-high throughput screening accelerates drug discovery by quickly identifying candidates, reducing time to market, and gaining a competitive edge. Molecular Chaperone reduces tau aggregation, preserving cognitive function and improving patient quality. Employs a precision medicine approach targeting tauopathy mechanisms, potentially...

Published: 9/11/2024 | Inventor(s): Abigail Esquivel, Laura Blair

Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics

Compact System and Method for Treating Urine and Other Wastewater

Advantages: The system offers enhanced sustainability by efficiently treating waste with minimal consumable inputs and hazardous byproducts. SAMBR provides a compact solution, achieving high treatment efficiency within the constrained space of spacecraft. The technology supports long-duration missions by recovering valuable resources, ensuring...

Published: 7/10/2024 | Inventor(s): Daniel Yeh, Talon Bullard, Luke Roberson, Daniella Saetta, Alexandra Smith

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Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Energy & Environment > Energy Engineering, Technology Classifications > Engineering > Chemical Engineering

Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)

Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...

Published: 11/6/2024 | Inventor(s): Jianfeng Cai, Heng Liu

Keywords(s): Alzheimer's Disease, Biotechnology, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience

Smart Mosquito Trap For Mosquito Classification

Advantages: Automates mosquito identification, reducing manual inspection efforts. Provides immediate species data, aiding timely mosquito control decisions. Integrates AI for proactive surveillance and targeted management strategies. Summary: Current methods of identifying mosquitoes trapped for research or control purposes are labor-intensive...

Published: 9/20/2024 | Inventor(s): Sriram Chellappan, Stephen Saddow, Brandon Wolfram

Keywords(s): Artificial Intelligence, Environmental Sciences

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Devices, Technology Classifications > Data/AI > D/AI Imaging

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