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A Microfluidic-coupled in vitro Model of the Blood-Brain Barrier (BBB)

Advantages Real-time trans endothelial electrical resistance (TEER) monitoring: embedded Ag/AgCl electrodes enables high-resolution impedance spectroscopy, outperforming conventional models Physiologically relevant tri-culture design: microfluidic flow mimics in vivo BBB hemodynamics with spatially separated HUVECs, astrocytes, and pericytes Enhanced...

Published: 6/5/2025 | Inventor(s): Shyam Mohapatra, Subhra Mohapatra, Tao Wang, Taylor Martinez

Keywords(s):

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications, Technology Classifications > Research Tools/Copyright, Technology Classifications > Medical > Neuroscience

RNA Binding Motif 3 (RBM3) Overexpressing Transgenic Mouse

Advantages • RBM3 upregulation reverses multiple tau phosphorylations post-TBI • Novel RBM3 Overexpressing Transgenic Mouse Model allows researchers to study the effects of RBM3 activation on tissue function, brain function, and brain injury Summary Traumatic brain injury (TBI) not only causes immediate neuronal damage but also...

Published: 5/30/2025 | Inventor(s): Travis Jackson

Keywords(s): Animal Models, Neuroscience

Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology

A High-Throughput NMR Method for In-Membrane Ligand-Screening

Advantages: Maintains the original structural and functional properties of receptor proteins Enables high-throughput screening through automated NMR workflows with minimal sample quantities Enhanced Signal-to-Noise Ratio improves detection of ligand-receptor interactions (e.g. binding orientations, kinetics, and dynamics) Applicable to any membrane...

Published: 4/30/2025 | Inventor(s): Libin Ye, Xudong Wang

Keywords(s): Drug Delivery and Nanomedicine, Drug Discovery

Category(s): Technology Classifications, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology

Novel Anti- Aggregation Therapeutic Targets Against Cystic Fibrosis Caused by Pseudomonas Aeruginosa

Advantages: Therapeutic Targets: Identified essential genes in Pa aggregate formation that can be potentially targeted with therapeutics Improved Infection Model: use of synthetic CF sputum media that closely mimics the physical and nutritional environment of CF sputum Potential for Broader Applications: can be extended to other bacterial species...

Published: 2/21/2025 | Inventor(s): Sophie Darch

Keywords(s): Medical Devices, Medical Diagnostics, Therapeutics

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Medical Diagnostics

Antibacterial-Modified Comet Assay for the Study of Genome Integrity in Bacterial Pathogenesis

Advantages: The modified comet assay delivers consistent, reproducible results, ensuring reliable data for bacterial pathogenesis and DNA damage/repair studies A cost-effective and user-friendly antimicrobial peptide, making the modified comet assay an economical solution The method is versatile, applicable to bacteria, mammalian cells, microbiome,...

Published: 1/14/2025 | Inventor(s): Marcus Cooke, Haley Lockhart

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Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Medical Diagnostics

New Target for Heart Failure Therapies: Modifying MRPS5/ATF4 Signaling in Cardiomyocytes

Advantages: Identification of MRPS5 as a Therapeutic Target: Reduction of MRPS5 expression stimulates cardiomyocyte proliferation and enhances heart function Discovery of the MRPS5 signaling axis: Decreased MRPS5 enhances ATF4 and Knl1, which promote cardiomyocyte, boosting cardiac recovery after myocardial injury Improved Survival and Cardiac...

Published: 1/17/2025 | Inventor(s): Da-Zhi Wang, John Mably

Keywords(s): Biotechnology, Cardiological Diseases Treatment, Cell & Tissue Culture & Engineering, Medical Diagnostics, Pharmaceuticals

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Pharmaceuticals

Treating Age-Related Hearing Loss with Rapamycin and Its Derivatives

Advantages: Novel Application of FDA approved drugs, rapamycin and its derivatives, for treating age-related hearing loss (ARHL). Targeting mTOR alleviates oxidative stress and inflammation in the cochlea, enhancing cellular health and resilience to age-related damage. Potential to Reverse or Delay Age-related hearing loss (ARHL) in patients. Summary: Age-related...

Published: 1/17/2025 | Inventor(s): Robert Frisina, Xiaohua Zhu, Bo Ding, Xiaoxia Zhu

Keywords(s): Pharmaceuticals, Therapeutics

Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices

Sensitive and Robust Biosensing Using Plasmonic Enhancement of Fluorescence by Rapid Thermal Annealed Silver Nanostructures

Advantages: Enhances cancer biomarker sensitivity Scalable production methods Enables low-concentration detection Ideal for portable diagnostics Summary: In cancer diagnostics, a major challenge is the detection of biomarkers at extremely low concentrations, particularly at the nanogram per milliliter (ng/ml) level, which is crucial for...

Published: 9/17/2024 | Inventor(s): Shuangming Li, Venkat Bhethanabotla

Keywords(s): Biomarker, Cancer Diagnostics

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Medical Diagnostics

Human Adipose-Derived Stem Cell Exosomes’ Packaging for Use at Room Temperature

Advantages: Promotes wound healing and supports positive long-term outcomes Reduces oxidative stress in human dermal fibroblasts (HDF) by exposing them to a composition containing adipose stem cell-derived exosomes Promising solution specifically tailored for penetrating wounds such as during military combat Summary: Penetrating injuries...

Published: 6/4/2025 | Inventor(s): Niketa Patel

Keywords(s): Wound and Tissue Healing

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Therapeutics

Vaccine Candidate for Preventing Clostridioides difficile Infection: Cell Wall Protein 2 (CWP 2)

Advantages: A recombinant Cwp2 protein that induces strong IgG and IgA antibody response in animal models. Decrease levels of C. difficile spores and toxins in feces and decrease mortality rates in immunized mice. Anti-Cwp2 antibodies delay the binding of C. difficile vegetative cells to human gut epithelial cells and prevent bacterial colonization....

Published: 1/31/2025 | Inventor(s): Xingmin Sun, Shaohui Wang

Keywords(s): Vaccines

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Medical > Biotechnology

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