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Novel Heart Failure Therapy: Farnesyltransferase Inhibition Targets Protein Aggregation in Cardiomyocytes
Advantages First-in-Class Mechanism: Targets a novel pathway—protein farnesylation—for heart failure treatment. Broad Therapeutic Potential: Effective in both HFrEF and HFpEF, addressing a major unmet need. Tested in multiple preclinical models: Danon disease cardiomyopathy (genetic model); HFpEF (diet-induced and hypertensive models);...
Published: 9/11/2025   |   Inventor(s): Kunhua Song, Congwu Chi, Amanda Conniff
Keywords(s): Cardiovascular Diseases, Drug Repurpose, Medical Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Chemistry
Cell Wall Protein 6 (Cwp6) as a Vaccine Component Against Clostridioides difficile Infection
Advantages Broader protection: targets bacterial colonization in addition to toxins A (TcdA) and B (TcdB) Applicability across different C. diff strains: Cwp6 is conserved across various C.diff ribotypes and toxinotypes Dual immune response: administration of Cwp6 with alum adjuvant elicits both systemic and IgG and mucosal IgA antibody responses Summary C.difficile...
Published: 8/26/2025   |   Inventor(s): Xingmin Sun, Lubem Agbendeh
Keywords(s):  
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases
A Novel Immunomodulatory Strategy for Treating Heart Failure in Aging Populations
Advantages Novel Mechanism of Action: Targets the Th17/IL17A signaling axis Validated Target: IL17A is already clinically validated in other inflammatory diseases (e.g., psoriasis, psoriatic arthritis), with FDA-approved therapies like secukinumab Strong Preclinical POC: transcriptomic, histological, and functional cardiac assessments showing reversal...
Published: 8/25/2025   |   Inventor(s): Wanling Xuan, Srinivas Tipparaju
Keywords(s): Cardiological Diseases Treatment, Cardiovascular Diseases, Drug Discovery
Category(s): zzCardiology, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Methionine Sulfoxide Reductase A (MsrA) Gene Therapy for Retinal Degeneration
Advantaages Targeted Protection Against Oxidative Stress Dual-Vector Delivery System (AAV and Lenti) Simple and scalable plasmid design for efficient production Suitable for major ophthalmology indications: Age-related macular degeneration (AMD), Retinitis pigmentosa, other oxidative stress-related retinal degenerations Summary Oxidative stress...
Published: 8/18/2025   |   Inventor(s): Manas Biswal
Keywords(s): Ophthalmology, Pharmaceuticals
Category(s): Technology Classifications, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
FLR: A Triple-Target Fusion Vaccine Candidate Against Clostridioides difficile
Advantages Multi-Antigen Targeting for Broad Protection: targets three distinct virulence factors (FliC, LP2, RBD2) simultaneously Targeting Hypervirulent Strain Pathogenesis Significant protection from infection and weight loss Reduced fecal toxin and spore levels Summary Clostridioides difficile (C. difficile) is a bacterium that colonizes...
Published: 8/7/2025   |   Inventor(s): Xingmin Sun
Keywords(s): Infectious Diseases Treatment, Vaccines
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering
Cell Culture Dishes with Dynamically Reconfigurable Surface Textures for Cell Expansion and Harvesting
Advantages Enzyme-free individual cell harvesting: avoids cellular damage, preserving cell viability and surface receptors Single-cell resolution: Releases dispersed individual cells rather than large confluent sheets, which is ideal for clonal assays Rapid (<1 min), mild stimulus-triggered detachment: triggers detachment via a brief temperature...
Published: 7/24/2025   |   Inventor(s): Nathan Gallant, Ryan Toomey, Michael Cross
Keywords(s):  
Category(s): Technology Classifications > Chemistry > Polymers, Technology Classifications > Medical > Biomaterials, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Research Tools/Copyright
A Microfluidic-coupled in vitro Model of the Blood-Brain Barrier (BBB)
Advantages Real-time trans endothelial electrical resistance (TEER) monitoring: embedded Ag/AgCl electrodes enables high-resolution impedance spectroscopy, outperforming conventional models Physiologically relevant tri-culture design: microfluidic flow mimics in vivo BBB hemodynamics with spatially separated HUVECs, astrocytes, and pericytes Enhanced...
Published: 6/5/2025   |   Inventor(s): Shyam Mohapatra, Subhra Mohapatra, Tao Wang, Taylor Martinez
Keywords(s):  
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications, Technology Classifications > Research Tools/Copyright, Technology Classifications > Medical > Neuroscience
RNA Binding Motif 3 (RBM3) Overexpressing Transgenic Mouse
Advantages • RBM3 upregulation reverses multiple tau phosphorylations post-TBI • Novel RBM3 Overexpressing Transgenic Mouse Model allows researchers to study the effects of RBM3 activation on tissue function, brain function, and brain injury Summary Traumatic brain injury (TBI) not only causes immediate neuronal damage but also...
Published: 5/30/2025   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology
A High-Throughput NMR Method for In-Membrane Ligand-Screening
Advantages: Maintains the original structural and functional properties of receptor proteins Enables high-throughput screening through automated NMR workflows with minimal sample quantities Enhanced Signal-to-Noise Ratio improves detection of ligand-receptor interactions (e.g. binding orientations, kinetics, and dynamics) Applicable to any membrane...
Published: 4/30/2025   |   Inventor(s): Libin Ye, Xudong Wang
Keywords(s): Drug Delivery and Nanomedicine, Drug Discovery
Category(s): Technology Classifications, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology
Novel Anti- Aggregation Therapeutic Targets Against Cystic Fibrosis Caused by Pseudomonas Aeruginosa
Advantages: Therapeutic Targets: Identified essential genes in Pa aggregate formation that can be potentially targeted with therapeutics Improved Infection Model: use of synthetic CF sputum media that closely mimics the physical and nutritional environment of CF sputum Potential for Broader Applications: can be extended to other bacterial species...
Published: 2/21/2025   |   Inventor(s): Sophie Darch
Keywords(s): Medical Devices, Medical Diagnostics, Therapeutics
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Medical Diagnostics
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