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Sensitive and Robust Biosensing Using Plasmonic Enhancement of Fluorescence by Rapid Thermal Annealed Silver Nanostructures

Advantages: Enhances cancer biomarker sensitivity Scalable production methods Enables low-concentration detection Ideal for portable diagnostics Summary: In cancer diagnostics, a major challenge is the detection of biomarkers at extremely low concentrations, particularly at the nanogram per milliliter (ng/ml) level, which is crucial for...

Published: 9/17/2024 | Inventor(s): Shuangming Li, Venkat Bhethanabotla

Keywords(s): Biomarker, Cancer Diagnostics

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Medical Diagnostics

Human Adipose-Derived Stem Cell Exosomes’ Packaging for Use at Room Temperature

Advantages: Promotes wound healing and supports positive long-term outcomes Reduces oxidative stress in human dermal fibroblasts (HDF) by exposing them to a composition containing adipose stem cell-derived exosomes Promising solution specifically tailored for penetrating wounds such as during military combat Summary: Penetrating injuries...

Published: 9/17/2024 | Inventor(s): Niketa Patel

Keywords(s): Wound and Tissue Healing

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Therapeutics

A Vaccine Technology for Preventing Clostridioides difficile Infection Using Cell Wall Protein 2 (CWP 2)

Advantages: A recombinant Cwp2 protein that induces strong IgG and IgA antibody response in animal models. Decrease levels of C. difficile spores and toxins in feces and decrease mortality rates in immunized mice. Anti-Cwp2 antibodies delay the binding of C. difficile vegetative cells to human gut epithelial cells and prevent bacterial colonization....

Published: 9/17/2024 | Inventor(s): Xingmin Sun, Shaohui Wang

Keywords(s): Vaccines

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Medical > Biotechnology

Modulating Molecular Chaperone DnaJB6b as a Novel Method to Regulate Tau Seeding and Propagation

Advantages: Semi-high throughput screening accelerates drug discovery by quickly identifying candidates, reducing time to market, and gaining a competitive edge. Molecular Chaperone reduces tau aggregation, preserving cognitive function and improving patient quality. Employs a precision medicine approach targeting tauopathy mechanisms, potentially...

Published: 9/11/2024 | Inventor(s): Abigail Esquivel, Laura Blair

Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics

Compact System and Method for Treating Urine and Other Wastewater

Advantages: The system offers enhanced sustainability by efficiently treating waste with minimal consumable inputs and hazardous byproducts. SAMBR provides a compact solution, achieving high treatment efficiency within the constrained space of spacecraft. The technology supports long-duration missions by recovering valuable resources, ensuring...

Published: 7/10/2024 | Inventor(s): Daniel Yeh, Talon Bullard, Luke Roberson, Daniella Saetta, Alexandra Smith

Keywords(s):

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Energy & Environment > Energy Engineering, Technology Classifications > Engineering > Chemical Engineering

Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)

Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...

Published: 9/12/2024 | Inventor(s): Jianfeng Cai, Heng Liu

Keywords(s): Alzheimer's Disease, Biotechnology, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience

Smart Mosquito Trap For Mosquito Classification

Advantages: Automates mosquito identification, reducing manual inspection efforts. Provides immediate species data, aiding timely mosquito control decisions. Integrates AI for proactive surveillance and targeted management strategies. Summary: Current methods of identifying mosquitoes trapped for research or control purposes are labor-intensive...

Published: 9/20/2024 | Inventor(s): Sriram Chellappan, Stephen Saddow, Brandon Wolfram

Keywords(s): Artificial Intelligence, Environmental Sciences

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Devices, Technology Classifications > Data/AI > D/AI Imaging

Intermetallic Fe Based Catalysts for Light Olefin Production

Advantages: High Selectivity: Up to 45% light olefin selectivity with CO2 included. Exceptional Stability: Maintains performance over a 72-hour run. Customizable Reactivity: Fe:In ratios tune surface composition for optimized olefin production and reduced by-products. Summary: This technology addresses a critical need in the chemical industry...

Published: 8/22/2024 | Inventor(s): John Kuhn, Babu Joseph, Yang He

Keywords(s): Chemistry and Chemical Engineering, Material Science

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Chemistry, Technology Classifications > Energy & Environment > Energy Engineering

Targeting Cellular Senescence by PD-L1 Binding Peptide Engineered Extracellular Vesicles

Advantages: Engineered extracellular vesicles (EVs) by surface modification with PD-L1 binding peptide and PEGylation to target senescent VSMCs. Promising novel interventions for age-related and vascular diseases. Efficacy: Proven uptake of modified EVs in the aorta of old mice and senescent VSMCs. Summary: Targeting senescent cells, particularly...

Published: 8/22/2024 | Inventor(s): Wanling Xuan, Srinivas Tipparaju, Vijaykumar Sutariya

Keywords(s): Drug Delivery and Nanomedicine, Genetics, Peptides

Category(s): Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Biotechnology

Drugs That Regulate Heparan Sulfate Expression for Cancer Treatment

Advantages: Developed a novel assay for identifying repurposed drugs targeting HS-related gene expression Revealed a dose-dependent inhibition of the HS-related gene EXT1 with Vitamin D/ Calcitriol EXT1 stable cell line with luciferase reporter ensures specificity in identifying EXT1 regulators, minimizing off-target effects Summary: Heparan...

Published: 9/3/2024 | Inventor(s): Lianchun Wang

Keywords(s): Biotechnology, Cancer Treatment, Medical Therapeutics Gene Therapy

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals

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