Search Results - xingmin+sun

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A Vaccine Technology for Preventing Clostridioides difficile Infection Using Cell Wall Protein 2 (CWP 2)
­Advantages: A recombinant Cwp2 protein that induces strong IgG and IgA antibody response in animal models. Decrease levels of C. difficile spores and toxins in feces and decrease mortality rates in immunized mice. Anti-Cwp2 antibodies delay the binding of C. difficile vegetative cells to human gut epithelial cells and prevent bacterial colonization....
Published: 9/17/2024   |   Inventor(s): Xingmin Sun, Shaohui Wang
Keywords(s): Vaccines
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Medical > Biotechnology
Receptor Binding Domain 2 of CDTb Component of the Clostridioides Difficile Binary Toxin CDT as a Vaccine Component Against C. Difficile Infection
­Advantages: Enhanced Vaccine Conservation: This technology ensures the conservation of critical vaccine components across diverse C. difficile strains, improving vaccine effectiveness. Immunogenic Potential: RBD2, a key discovery, exhibits exceptional immunogenicity, promising robust immune responses in vaccine recipients. Inhibition of CDT...
Published: 9/3/2024   |   Inventor(s): Xingmin Sun, Shaohui Wang
Keywords(s): Infectious Diseases, Vaccines
Category(s): Technology Classifications > Medical > Infectious Diseases
Recombinant Fusion Protein Containing Clostridioides Difficile Flagellin Proteins FliC and FliD as a Vaccine Candidate Against C. Difficile Infection
­Advantages: Novel Vaccine Approach: Vacine targeting C. difficile flagellar proteins FliC and FliD. Enhanced Protection: FliCD provides robust immunity, reduces C. difficile infection severity, and decreases spore and toxin levels in feces. Potential Alternative Therapy: Anti-FliCD serum demonstrates promise as an adjunct therapy for CDI,...
Published: 2/13/2024   |   Inventor(s): Xingmin Sun
Keywords(s): Infectious Diseases, Vaccines
Category(s): Technology Classifications > Medical > Infectious Diseases
Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation
­Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...
Published: 10/2/2023   |   Inventor(s): Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang
Keywords(s): Drug Discovery, Infectious Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology
Antimalarial peptides
­Competitive Advantages Potential treatment for malaria Could be effective against drug resistant strain Dd2 The resulting compounds showed no significant cytotoxicity Summary Malaria, caused by the parasite Plasmodium falciparum, continues to threaten much of the world population and there is a pressing need for expanding treatment options....
Published: 9/3/2024   |   Inventor(s): Bill Baker, Joe Bracegirdle, James Rocca, John Adams, Nerida Wilson, Debora Casandra, Xingmin Sun, Anne-Claire Limon
Keywords(s): Infectious Diseases Treatment, Peptides, Therapeutics
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Infectious Diseases
A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Against Clostridium difficile
Competitive Advantages Bypasses antibacterial resistance More effective than metronidazole and vancomycin Works over a range of pHs Inhibits cytotoxicity of Toxin B Summary USF inventors have developed a novel fusion protein that is the combination of a human defensin and the lysis protein of a bacteriophage called LHD. LHD bypasses antibiotic...
Published: 5/25/2023   |   Inventor(s): Xingmin Sun
Keywords(s):  
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical
Oral Spore Vaccines AGainst Clostridium Difficile Infection
Competitive Advantages Targets main virulent factors Reduces distribution of toxigenic spores Improved efficacy No need for cold storage Summary USF researchers have designed an oral vaccine to protect users against C. difficile infection. This vaccine uses non-toxigenic C. difficile (NTCD) strains to carry non-pathogenic toxin fragments. These...
Published: 8/25/2023   |   Inventor(s): Xingmin Sun, Abraham Sonenshein
Keywords(s):  
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical