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Search Results - technology+classifications+%3e+drug+delivery
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Bioactive Telodendrimer Nanocarrier for Antibiotics Delivery and Immune Modulation
Novel telodendrimer nanoparticles have been developed to enhance the delivery and safety profile of the antibiotic Polymyxin B by improving its stability and reducing toxicity during treatment. Background: Polymyxin B (PMB) is a powerful antibiotic used to treat infections caused by Gram-negative bacteria, but its clinical application is limited...
Published: 6/12/2026
|
Updated: 6/12/2026
|
Inventor(s):
Juntao Luo
,
Dandan Guo
,
Md Shanewaz Hossan
,
Changying Shi
Keywords(s):
Technologies
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Drug Delivery
Pancreas-specific mRNA delivery enabled by sulfonium lipid nanoparticles
This technology presents a novel class of lipid nanoparticles engineered for targeted delivery of mRNA specifically to the pancreas following systemic administration. Background: Effective delivery of RNA therapeutics to specific organs remains a significant challenge in biomedical research. The pancreas, in particular, has been a difficult target...
Published: 6/12/2026
|
Updated: 6/11/2026
|
Inventor(s):
Yamin Li
,
Yuqin Men
Keywords(s):
mRNA
,
nanoparticle-enhanced delivery
,
nanoparticles
,
Technologies
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Drug Delivery
A lung-targeting britannin-lipid nanoparticle formulation and use thereof
This technology is a novel lung-targeting britannin-lipid nanoparticle formulation designed to effectively treat acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) by inhibiting lung inflammation. Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe lung conditions characterized by intense...
Published: 6/12/2026
|
Updated: 6/11/2026
|
Inventor(s):
Yamin Li
,
Qinghe Meng
,
Daping Fan
Keywords(s):
acute lung injury
,
drug delivery
,
Technologies
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Drug Delivery
Development of novel liver-targeting glucocorticoid prodrugs
This technology presents novel liver-targeting glucocorticoid prodrugs designed to improve the treatment of inflammatory liver diseases and sepsis with enhanced efficacy and reduced systemic side effects. Background: Inflammatory liver diseases and sepsis represent significant clinical challenges due to their complex immune responses and the difficulty...
Published: 6/12/2026
|
Updated: 6/11/2026
|
Inventor(s):
Hong Lu
,
Juntao Luo
,
Dandan Guo
Keywords(s):
glucocorticoid
,
inflammatory liver disease
,
liver-selective
,
nanoparticle
,
prodrug
,
sepsis
,
Technologies
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Drug Delivery
Chemical Modifications of Substrates Using Zwitterionic-Functionalized Dendrimers
Novel platform for biomaterials development with advanced physiological properties BACKGROUND: The need for improved biomaterials is a continuous challenge in the clinical field. Extended physiological circulation times, reduced immune responses, and lowered cytotoxicity are a few parameters crucial for therapeutic and diagnostic biomaterials. ...
Published: 4/16/2026
|
Updated: 3/23/2026
|
Inventor(s):
Chong Cheng
,
Mingxuan Zhang
,
Yun Wu
,
Ziwen Zhang
Keywords(s):
Featured
,
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Biological Materials
,
Technology Classifications > Diagnostics
,
Technology Classifications > Drug Delivery
,
Technology Classifications > Materials and Chemicals
,
Technology Classifications > Research Tools and Reagents
Functionalized Dendrimers with Regioselective Reactivity
Novel compositions of zwitterionic dendrimers and derived polymers BACKGROUND: There is a strong need for new classes of reactive reagents for the generation of novel materials with pre-defined characteristics. Here, new compounds can be generated employing properties associated with zwitterions, dendrimers, or combination materials. TECHNOLOGY...
Published: 4/16/2026
|
Updated: 3/23/2026
|
Inventor(s):
Chong Cheng
,
Mingxuan Zhang
,
Yun Wu
,
Ziwen Zhang
Keywords(s):
Featured
,
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Biomedical Science and Engineering
,
Technology Classifications > Drug Delivery
,
Technology Classifications > Materials and Chemicals
,
Technology Classifications > Research Tools and Reagents
,
Technology Classifications > Biological Materials
,
Technology Classifications > Diagnostics
Netrin-4–Mediated Disruption of Basement Membranes for Targeted Therapeutic Delivery
Novel tools that promote the delivery of therapeutics to treat inner retinal diseases such as diabetic retinopathy, retinal vein occlusion, and retinitis pigmentosa. Background: Non-surgical access to tissues for direct biological manipulation, e.g. gene transfer, stem cell transplantation, and drug delivery, can be difficult because many tissues...
Published: 3/9/2026
|
Updated: 3/3/2026
|
Inventor(s):
Dale Hunter
,
William Brunken
,
Peter Yurchenco
,
Karen Mckee
Keywords(s):
biologic therapies
,
drug delivery component
,
Technologies
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Drug Delivery
,
Technology Classifications > Therapeutics and Vaccines
Lipid nanoparticles for targeted delivery of therapeutic agents in acute lung injury
This technology uses lung-targeting lipid nanoparticles to deliver a combination of anti-inflammatory and immune-modulating drugs directly to the lungs, offering a more effective and targeted treatment for acute lung injury and acute respiratory distress syndrome. Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)...
Published: 4/2/2026
|
Updated: 1/15/2026
|
Inventor(s):
Yamin Li
,
Yuqin Men
,
Robert Cooney
,
Qinghe Meng
Keywords(s):
acute lung injury
,
anti-inflammatory therapeutic
,
drug delivery
,
Technologies
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Drug Delivery
Sulfonium Lipid Nanoparticles for Intranasal mRNA Delivery to Lung Epithelial and Immune Cells
This technology uses specially designed sulfonium lipid nanoparticles to deliver mRNA directly to lung cells through the nose, offering a non-invasive, more effective and targeted treatment for pulmonary diseases like asthma and cystic fibrosis. Background: The field of pulmonary medicine faces significant challenges in the treatment of diseases...
Published: 6/3/2026
|
Updated: 1/9/2026
|
Inventor(s):
Yamin Li
,
Yuqin Men
Keywords(s):
active pharmaceutical ingredient
,
chemicals
,
drug delivery
,
Technologies
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Biomedical Science and Engineering
,
Technology Classifications > Drug Delivery
Virus-Like Particles for mRNA Delivery
Virus-like particles have been engineered for drug delivery, gene editing applications, mRNA delivery and overcoming barriers in mouse lungs. Background: Recent biomedical research has shown increased interest in the use of virus-like particles as a drug delivery vehicle. Current viral vectors have been shown to cause adverse immunological responses,...
Published: 4/16/2026
|
Updated: 5/19/2025
|
Inventor(s):
Sriram Neelamegham
,
Qi Yang
Keywords(s):
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Biological Materials
,
Technology Classifications > Drug Delivery
,
Technology Classifications > Healthcare
,
Technology Classifications > Gene Therapy
,
Technology Classifications > Materials and Chemicals
,
Technology Classifications > Research Tools and Reagents
,
Technology Classifications > Screens and Assays
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