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Search Results - sriram+neelamegham
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Glycosyltransferase Mutation-Activity Landscape
A streamlined high-throughput platform for engineering glycosyltransferases and glucosidases Background: Glycosyltransferases are enzymes that commonly transfer monosaccharides to proteins and lipid scaffolds. These enzymes constitute ~2% of the coding human genome, representing over 200 proteins. Mutations in glycosyltransferases lead to disease;...
Published: 9/12/2025
|
Inventor(s):
Sriram Neelamegham
,
Ryoma Hombu
Keywords(s):
Biotechnology
,
Diagnostic
,
Pharmaceutical
,
Technologies
,
Therapeutic and Vaccines
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Biological Materials
,
Technology Classifications > Diagnostics
,
Technology Classifications > Materials and Chemicals
,
Technology Classifications > Screens and Assays
,
Technology Classifications > Research Tools and Reagents
,
Technology Classifications > Biomedical Science and Engineering
Virus-Like Particles for mRNA Delivery
Virus-like particles have been engineered for drug delivery, gene editing applications, mRNA delivery and overcoming barriers in mouse lungs. Background: Recent biomedical research has shown increased interest in the use of virus-like particles as a drug delivery vehicle. Current viral vectors have been shown to cause adverse immunological responses,...
Published: 9/12/2025
|
Inventor(s):
Sriram Neelamegham
,
Qi Yang
Keywords(s):
Featured
,
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Biological Materials
,
Technology Classifications > Drug Delivery
,
Technology Classifications > Healthcare
,
Technology Classifications > Gene Therapy
,
Technology Classifications > Materials and Chemicals
,
Technology Classifications > Research Tools and Reagents
,
Technology Classifications > Screens and Assays
Development of Lectins with Protein Engineering
Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue. Background: Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 9/12/2025
|
Inventor(s):
Sriram Neelamegham
,
Ryoma Hombu
Keywords(s):
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Biological Materials
,
Technology Classifications > Biomedical Science and Engineering
,
Technology Classifications > Diagnostics
,
Technology Classifications > Materials and Chemicals
,
Technology Classifications > Research Tools and Reagents
,
Technology Classifications > Screens and Assays