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Protein Oxidation as a Metric of Blood Sample Integrity
Human blood plasma and serum (P/S) samples from clinical studies are often archived by biobanks for future research. Biospecimen integrity is crucial for ensuring the validity of clinically oriented research. P/S samples are not intrinsically stable. Inappropriate handling and storage conditions can result in protein oxidation, which can dramatically...
Published: 2/23/2023   |   Inventor(s): Chad Borges, Matthew Schaab, Douglas Rehder, Joshua Jeffs
Keywords(s): Biocollections, Biospecimen integrity, Screening
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Buffers for coupling mass spectrometric immunoassay (MSIA) with electrospray ionization-based mass spectrometry
Mass spectrometry (MS) analysis is a ubiquitous and important analytical technique in protein research and analysis. Some of the most common technical issues involve low-concentration solutions (sub-µM) with their attendant adsorptive loss and oxidation of proteins to be analyzed. Carrier proteins are sometimes used to prevent adsorptive protein...
Published: 2/23/2023   |   Inventor(s): Douglas Rehder, Matthew Schaab, Chad Borges
Keywords(s): Bio-Technology
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools