Search Results - douglas+rehder

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Glycan Nodes: Multiplexed Glycotransferase Surrogate Analysis for Detecting and Monitoring Cancer
Cancer biologists have known for decades that tumor cells display aberrant sugar polymer (glycan) structures. This means that if glycans can be analyzed in the right way(s), they should serve as excellent markers for the presence and progression of cancer. Altered activity of the enzymes that build glycans (glycotransferases, GTs) is the immediate upstream...
Published: 2/23/2023   |   Inventor(s): Chad Borges, Douglas Rehder
Keywords(s): Biosignature, Cancer, Detection, Glycans, Health Monitoring, Molecular Diagnostics, Personalized medicine
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs)
Protein Oxidation as a Metric of Blood Sample Integrity
Human blood plasma and serum (P/S) samples from clinical studies are often archived by biobanks for future research. Biospecimen integrity is crucial for ensuring the validity of clinically oriented research. P/S samples are not intrinsically stable. Inappropriate handling and storage conditions can result in protein oxidation, which can dramatically...
Published: 2/23/2023   |   Inventor(s): Chad Borges, Matthew Schaab, Douglas Rehder, Joshua Jeffs
Keywords(s): Biocollections, Biospecimen integrity, Screening
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Buffers for coupling mass spectrometric immunoassay (MSIA) with electrospray ionization-based mass spectrometry
Mass spectrometry (MS) analysis is a ubiquitous and important analytical technique in protein research and analysis. Some of the most common technical issues involve low-concentration solutions (sub-µM) with their attendant adsorptive loss and oxidation of proteins to be analyzed. Carrier proteins are sometimes used to prevent adsorptive protein...
Published: 2/23/2023   |   Inventor(s): Douglas Rehder, Matthew Schaab, Chad Borges
Keywords(s): Bio-Technology
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools