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Search Results - akhil+maheshwari
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Anti-Thrombin Nanoparticles and Therapeutics to Treat Necrotizing Enterocolitis
Advantages: Bivalirudin-tagged nanoparticles bind and neutralize nascent thrombin in clots, minimizing systemic anticoagulant effects Anti-thrombin nanoparticle confines its anticoagulant activity to sites of clot formation, limiting excessive systemic coagulation inhibition Dual therapeutic and diagnostic potential allows clinicians to treat NEC...
Published: 2/5/2025
|
Inventor(s):
Akhil Maheshwari
,
Samuel Wickline
,
Koppenruncholan Namachivayam
,
Hua Pan
Keywords(s):
Gastrointestinal / Digestive Health
,
Pharmaceuticals
Category(s):
Technology Classifications > Medical > Pharmaceuticals
A Novel Preclinical Model of Neonatal Necrotizing Enterocolitis
Advantages: Uniquely replicates the clinical scenario of RBC transfusion-exacerbated NEC in anemic neonates, providing a more accurate model than the traditional method Provide superior mechanistic insights, offering precise investigation of molecular pathways compared to in vitro intestinal injury assays Cost-effective and high-throughput experimentation,...
Published: 1/17/2025
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Inventor(s):
Akhil Maheshwari
,
Mohan Krishnan
Keywords(s):
Animal Models
,
Research Tools
Category(s):
Technology Classifications > Medical