Search Results - yuanzhou+chen

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YAP-TEAD Core Inhibitors for Developing Cancer Therapeutics

Inhibit YAP-TEAD Interactions for the Treatment of Diseases with Altered Hippo Signaling These small molecule inhibitors target TEA domain (TEAD) proteins, with the potential to treat diseases with altered Hippo signaling, such as Hepatocellular Carcinoma (HCC) and Hepatoblastoma (HB). The Hippo signaling pathway is vital to organ growth control, stem...

Published: 9/3/2024 | Inventor(s): Chenglong Li, Chen Zhou, Liya Pi, Chunbao Sun

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics

Object-Detecting Deep Learning for Multi-Event Electrochemical Data (Case No. 2024-088)

Summary: UCLA researchers in the Department of Chemistry and Biochemistry developed a custom-designed deep learning architecture for object detection and mechanisms classification to streamline the experimental design of cyclic voltammograms. Background: Cyclic voltammetry, a widely used electrochemical test, serves as a crucial tool in understanding...

Published: 8/23/2024 | Inventor(s): Chong Liu, Quanquan Gu, Benjamin Hoar, Weitong Zhang, Yuanzhou Chen

Keywords(s): 2D ultrasound imaging, Artifical Intelligence (Machine Learning, Data Mining), artificial electromagnetic materials, bioelectronics, Biomaterial, electrochemical sensors, Electronics & Semiconductors, Lithium Battery, Lithium-Ion Battery, Machine Learning, Materials, Medical Devices and Materials, Medical diagnostics, Pharmaceutical Drug, Pharmaceutical testing, Rechargeable Battery, zzenergy storage

Category(s): Electrical > Electronics & Semiconductors, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Storage, Energy & Environment > Water Monitoring & Treatment, Software & Algorithms > Image Processing, Software & Algorithms > Artificial Intelligence & Machine Learning, Electrical > Signal Processing

Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation

Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...

Published: 10/2/2023 | Inventor(s): Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang

Keywords(s): Drug Discovery, Infectious Diseases Treatment

Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology

A novel method to fabricate nanostructured bulk materials with tailored grain-boundary conditions

Overview Engineering at the grain boundary - the meeting points of where the crystals or grains of varying size and orientation that comprise a material meet—is crucial to fully utilizing a new material. This area of research is pivotal to fully utilizing the mechanical, electrical, and thermal transport properties of a variety of materials....

Published: 5/21/2023 | Inventor(s): Ou Chen, Yasutaka Nagaoka

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Category(s): Engineering and Sensors

Novel Multi-Omics Aging Clock

A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...

Published: 3/12/2024 | Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen

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Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools

Autonomous Drone for railroad track inspection

Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...

Published: 3/15/2023 | Inventor(s): Yu Qian, Yi Wang, Chen Chen

Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation

Category(s): Engineering and Physical Sciences

Tetrazole & Coumarin Phosphonate Based Broad-Spectrum Beta-Lactamase Inhibitors

Competitive Advantages Combats bacterial antibiotic resistance to β-Lactamase Effectively inhibits against the different classes of β-Lactamase Enhances effectiveness of current β-lactam antibiotics treatments Summary Our inventors have discovered tetrazole and coumarin phosphonate based compounds can actively inhibit...

Published: 6/27/2024 | Inventor(s): Yu Chen, Orville Pemberton, Adam Renslo, Priyadarshini Jaishankar

Keywords(s): Infectious Diseases Treatment, Pharmaceuticals

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical

Beta-Lactamase Inhibitor Compositions, Methods of Use, and Methods of Treatment

Competitive Advantages Can restore the efficacy of beta-lactam antibiotics Overcomes antibiotic resistance May help to develop new antibiotic treatment regimens Treats multi-drug resistant organisms Summary Our researchers have developed compositions comprised of a beta-lactamase inhibitor and methods of use to treat various infections and...

Published: 6/27/2024 | Inventor(s): Adam Renslo, Derek Nichols, Priyadarshini Jaishankar, Yu Chen, Erica Lauterwasser

Keywords(s): Infectious Diseases Treatment, Pharmaceuticals

Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical

2015-671 Underground Shafts for Hydrogen Storage

SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...

Published: 7/19/2023 | Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove

Keywords(s): Energy & Water

Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage

Pathogen Molecular Detection Platform

Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...

Published: 2/23/2023 | Inventor(s): Alexander Green, Yu Zhou

Keywords(s): Bio-Technology

Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools

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