Search Results - niketa+patel

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Human Adipose-Derived Stem Cell Exosomes’ Packaging for Use at Room Temperature

Advantages: Promotes wound healing and supports positive long-term outcomes Reduces oxidative stress in human dermal fibroblasts (HDF) by exposing them to a composition containing adipose stem cell-derived exosomes Promising solution specifically tailored for penetrating wounds such as during military combat Summary: Penetrating injuries...

Published: 9/17/2024 | Inventor(s): Niketa Patel

Keywords(s): Wound and Tissue Healing

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Therapeutics

Novel small molecule targeting lncRNA in neurodegenerative diseases and tauopathies

Advantages: Developed lead compound #67 to elevate GAS5 levels and also enhances neuronal insulin signaling, offering a comprehensive approach to neurodegenerative complexities. Noninvasive Insights: GAS5's presence as a serum biomarker enables noninvasive disease assessment and NPC86 treatment efficacy confirmation. Compound #67's...

Published: 3/14/2024 | Inventor(s): Niketa Patel, Jianfeng Cai

Keywords(s): Medical Therapeutics Gene Therapy, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Neuroscience

Treatment of Traumatic Brain Injury Using Adipocyte Derived Stem Cells Secreting Long Noncoding RNAs, NEAT1 and MALAT1, or ADSC Conditioned Media

Competitive Advantages Improved cognitive performance Improved motor skills Prevents cortical and hippocampal damage Summary USF researchers have shown that lncRNAs secreted from adipocyte derived stem cells (ADSC) can improve certain motor, cognitive, and histological deficits related to TBI and other related diseases. Rats with induced...

Published: 8/26/2023 | Inventor(s): Cesario Borlongan, Lisa Gould, Niketa Patel, Paula Bickford, Denise Cooper (VA)

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Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience

Characterization and Manipulation of Adipose Stem Cell Depots to a Metabolically Healthy State

Competitive Advantages Successfully reprograms obese omental ASCs Increases the amount of metabolically healthy subcutaneous-like adipose Reduction in obesity comorbidities Metabolic disease treatment option Summary USF researchers have developed a method of reprogramming obese omental ASCs into a metabolically healthier subcutaneous-like...

Published: 6/14/2023 | Inventor(s): Niketa Patel, Ghattas El Bassit

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Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical

Treatment of Brain Injuries Using Exosomes from Adipose-Derived Stem Cells and Insulin

Competitive Advantages Promotes neuronal survival and regeneration Easy isolation in large quantities Minimal immune response Potential therapeutic application to treat brain injuries Summary USF researchers have demonstrate that hASC secrete factors which enhance the regeneration and survival of neurons. Exosomes from the hASC...

Published: 8/25/2023 | Inventor(s): Niketa Patel, Paula Bickford

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Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience

GAS5 mediated metabolic regulation in neurodegenerative diseases

Competitive Advantages • Potential diagnosis and treatment of sporadic, late onset Alzheimer’s disease (sAD) • Allows for early detection of AD • Novel compound to increase lncRNA levels for in vivo sAD treatment Summary Using transcriptomics, scientists at USF have shown that GAS5 is significantly reduced in patients...

Published: 7/25/2024 | Inventor(s): Niketa Patel, Jianfeng Cai

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Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience

GAS5-binding Small Molecule for Treatment of Diabetes and Cancer

Competitive Advantages Stabilize and increase Gas5 levels Controls glucose metabolism and uptake Multi-faceted and specific therapy Promotes Apoptosis Summary A technique has been developed to diagnose and predict type-2 diabetes mellitus via human GAS5; a long noncoding RNA(LncRNAs). LncRNAs are transcribed by all cell types however their...

Published: 8/22/2024 | Inventor(s): Niketa Patel

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Category(s): Technology Classifications > Cancer, Technology Classifications > Medical > Endocrinology, Technology Classifications > Medical

Sortilin-Binding Small Molecule Increases Glucose Uptake

Competitive Advantages Selectively binds to wild-type sortilin Increases cellular glucose uptake Compensates for reduced sortilin activity in obese patients Summary USF inventors have discovered novel therapeutic compounds that have shown to bind favorably to wild-type (WT) sortilin and increase glucose uptake, especially when used...

Published: 8/26/2023 | Inventor(s): Robert Sparks, Wayne Guida, Niketa Patel

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Category(s): Technology Classifications > Medical > Endocrinology, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical

Gas5 lncRNA Biomarker Signature for Prediction and Management of Diabetes

Competitive Advantages Establishes GAS5 a circulating biomarker in blood, urine, or saliva Easy integration into routine care to assess risk of developing diabetes Non-invasive biomarker that predicts pre-diabetic and diabetic conditions Summary Our inventors have identified GAS5, an RNA-based biofluid marker for prediction and management of...

Published: 8/2/2024 | Inventor(s): Niketa Patel

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Category(s): Technology Classifications > Medical > Endocrinology, Technology Classifications > Medical