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Activation of E6Ap/Ube3A-Mediated Protein Ubiquitination and Degradation Pathways By A Cyclic G-Aa Peptide
Advantages By modulating E3 ligase activity, it is possible to regulate protein degradation pathways, gene activation, and other cellular functions. The research expands the therapeutic landscape by introducing the concept of E3 activators alongside E3 inhibitors, PROTACs, and molecular glues. Synthetic ligands, such as γ-AA peptides, offer...
Published: 4/18/2024   |   Inventor(s): Jianfeng Cai, Bo Huang, Jun Yin, Li Zhou, Ruochuan Liu
Keywords(s): Cancer Treatment, Drug Discovery, Neurodegenerative Diseases, Oncology
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Neuroscience