Search Results - bo+huang

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­PROBE-BASED DEVICE-FREE SINGLE-CELL RNA PROFILING
­PROBE-BASED DEVICE-FREE SINGLE-CELL RNA PROFILING Researchers at UCSF have developed a novel method for probe-based scRNA-seq. Single cell RNA sequencing (scRNA-seq) has revolutionized the field of cell biology by enabling nucleic acid profiling at single cell resolution. Typical detection efficiency of scRNA-seq ranges between 5-45%, mostly...
Published: 12/5/2023   |   Inventor(s): Bo Huang, Daniel Foyt
Keywords(s): Barcoding, RNA Sequencing, ScRNA-seq
Category(s): Technology Classifications > Biology
Activation of E6Ap/Ube3A-Mediated Protein Ubiquitination and Degradation Pathways By A Cyclic G-Aa Peptide
Advantages By modulating E3 ligase activity, it is possible to regulate protein degradation pathways, gene activation, and other cellular functions. The research expands the therapeutic landscape by introducing the concept of E3 activators alongside E3 inhibitors, PROTACs, and molecular glues. Synthetic ligands, such as γ-AA peptides, offer...
Published: 4/18/2024   |   Inventor(s): Jianfeng Cai, Bo Huang, Jun Yin, Li Zhou, Ruochuan Liu
Keywords(s): Cancer Treatment, Drug Discovery, Neurodegenerative Diseases, Oncology
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Neuroscience
RECONSTITUTION OF SPLIT-HALOTAG VIA ORTHOGONAL TAG BINDING DOMAINS
RECONSTITUTION OF SPLIT-HALOTAG VIA ORTHOGONAL TAG BINDING DOMAINS Researchers at UCSF have developed a method using split HaloTags to tag multiple proteins in a single assay and measure their interactions. Due to new technologies such as CRISPR/Cas9 gene editing, it is now easier to modify DNA than at any other point in human history. One of the...
Published: 5/18/2023   |   Inventor(s): David Brown, Suraj Makhija, Bo Huang
Keywords(s): FACS, HaloTag, Knock-In Cell Lines, Protein Fragment, Self-Complementing Protein Fragments, Split Protein System
Category(s): Technology Classifications > Biology
Machine Learning Method to Adapt and Identify Multiple-Input Multiple-Output (MIMO) systems
System Identification Based on Statistical Dependence This modularized machine learning model improves the accuracy of deep neural network (DNN) models. The standard methodology for machine learning is through backpropagation (BP) algorithms. While backpropagation allowed tuning the parameters of multilayer neural networks directly from data in supervised...
Published: 9/6/2022   |   Inventor(s): Jose Principe, Bo Hu
Keywords(s):  
Category(s): Technology Classifications > Engineering > Electrical, Technology Classifications > Engineering > Computer Science
Processing Technique for Ceramic- based Energy Conversion and Storage Devices
Due to rising carbon emissions, extreme weather events and other environmental threats, the demand for alternative energy sources is greater than ever. Therefore, businesses and communities are asking for three things: more affordable electricity, more resilient power, and cleaner energy. Fuel cells, electrolysis cells, membrane reactors, and solid-state...
Published: 10/8/2024   |   Inventor(s): Hai Xiao, Jianhua Tong, Fei Peng, Kyle Brinkman, Jincheng Lei, Yuzhe Hong, Hua Huang, Shenglong Mu, Rajendra Bordia
Keywords(s):  
Category(s): Manufacturing
Automated Pain Detection in Pediatric Care
uot;Times New Roman",serif; font-size:12pt">Unmet Need: Continuous pain assessment in infants Continuing advances in intensive care have made it possible for premature infants to survive outside the uterus in Neonatal Intensive Care Unit (NICU) even at very early stages of development. Infants in the NICU may receive an estimated 10-14 painful...
Published: 10/8/2024   |   Inventor(s): Subhanshu Gupta, Huan Hu, Martin Schiavenato
Keywords(s):  
Category(s): Technologies > Health & Well-being > Health-IT, Technologies > Health & Well-being > Medical Devices, Technologies > Energy & Environment > Computer Hardware/Software, Technologies > Energy & Environment > Electrical/Electronics
Simple, Accurate, Real-Time 3D Imaging System
Brief Description:This invention relates to a simple, inexpensive, automated 3-D imaging system that will allow a physician to perform a rapid preoperative and postoperative 3-D analysis of the head and neck. The technology aids in airway quality evaluation in anesthesiology; plastic surgery and biometric systems, including 3-D facial recognition.Applications:...
Published: 5/7/2024   |   Inventor(s): Bo Hu, Jacek Wojtczak, Christopher Brown
Keywords(s):  
Category(s): Imaging, Informatics, Optics
Reconstruction of an Image Mosaic
Brief Description:This is software which can automatically knit together images into a continuous mosaic. The process involves fiding matching features in the input image, rejecting inconsistent matches, and computing a projective mapping which wraps the images into a common coordinate system for display.Applications:The software can be used for automatic...
Published: 5/23/2023   |   Inventor(s): Randal Nelson, Christopher Brown, Bo Hu
Keywords(s):  
Category(s): Imaging