Search Results - xue+zhao

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Roadside LiDAR Sensing for Obtaining All-Traffic Trajectory and Traffic Performance Analysis
Background LiDAR technology, traditionally applied in autonomous vehicle navigation, has now expanded its footprint into roadside infrastructure. Roadside LiDAR aims to provide comprehensive traffic data, including behavior-level trajectory data for all road users. However, there exist challenges such as accurate differentiation between static and moving...
Published: 11/20/2023   |   Inventor(s): Hao Xu
Keywords(s):  
Category(s): Technology Classifications > Engineering, Technology Classifications > Software
Novel Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treatment of Solid Tumors
Abstract: Topoisomerase 1 (TOP1) is an essential enzyme that plays a critical role in DNA transcription and replication. TOP1 inhibitors are a known class of anti-cancer agents that work to interrupt DNA replication in cancer cells, causing cell death. Since the discovery of the TOP1 inhibitor camptothecin (CPT) from plant extracts more than 60 years...
Published: 5/22/2024   |   Inventor(s): Xue Zhao, George Lountos, Evgeny Kiselev, David Waugh, Yves Pommier, Terrence Burke
Keywords(s): Burke, CANCER, solid tumor, Tdp1, TOP1, Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1, Zhao
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Small Molecule Inhibitors of Drug Resistant Forms of HIV-1 Integrase
Abstract: Integrase strand transfer inhibitors (“INSTIs”) are currently in use as a component of prophylactic antiretroviral therapy for preventing HIV-1 infection from progressing to AIDS. Three INSTIs are approved by the FDA for inclusion in antiretroviral regiments: raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG). Clinicians have already...
Published: 5/22/2024   |   Inventor(s): Xue Zhao, Terrence Burke, Yves Pommier, Stephen Hughes, Mathieu Metifiot, Stephen Smith, Barry Johnson, Christophe Marchand
Keywords(s): dolutegravir, drug resistant HIV, elvitegravir, HIV therapy, Integrase, raltegravir, strand transfer
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/23/2023   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors