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Search Results - sami+abdulkadir
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Novel Peptide-Based Inhibitors of HIF-1α for Cancer Therapy
Advantages: Developed helical mimetics of HIF-1α based on sulfonyl-γ-AA peptides that selectively target HIF-1α to target metastasis and therapy resistance in solid tumors. Inhibitors are stable and cell permeable. HC11, HC13, and HC14 sulfonyl-γ-AA peptides efficiently inhibit HIF-1α activity and reduce expression...
Published: 9/3/2024
|
Inventor(s):
Jianfeng Cai
,
Sami Abdulkadir
Keywords(s):
Cancer Treatment
Category(s):
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Oncology
Novel Vascular Endothelial Growth Factor Mimetics as Inhibitors or Activators of Angiogenesis
Advantages: Novel helical VEGF mimicking peptides that can inhibit or activate angiogenesis. Mimetics hold promise as therapeutic agents for intervention in angiogenesis-related diseases. The sulfono-γ-AA peptides exhibit remarkable stability against proteolytic hydrolysis, ensuring their durability and effectiveness in biological systems. Summary: Angiogenesis,...
Published: 6/11/2024
|
Inventor(s):
Jianfeng Cai
,
Sami Abdulkadir
Keywords(s):
Cancer
,
Peptides
,
Therapeutics
Category(s):
Technology Classifications > Cancer
,
Technology Classifications > Medical > Oncology
,
Technology Classifications > Medical > Therapeutics