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Search Results - zhigao+wang
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Novel Therapy to Prevent Kidney Transplant Rejection
Advantages Targets root cause (cell death), not just immune suppression. Upstream Target: Blocks necroptosis before RIPK1 activation for earlier, more selective intervention. Novel mechanism outside the crowded RIPK1 space with strong IP positioning. Robust In Vivo Efficacy: ~50% ↓ graft injury; lead candidate shows ~65% ↓ creatinine...
Published: 5/14/2026
|
Updated: 1/12/2026
|
Inventor(s):
Lei Wang
,
Zhigao Wang
,
Jianfeng Cai
Keywords(s):
Organ Transplantation
,
Renal / Kidney
Category(s):
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Chemistry
,
Technology Classifications > Medical > Therapeutics
MLKL Polymerization-Induced Lysosome Membrane Permeabilization Drives Necroptotic Cell Death
Advantages: Novel Drug Targets: Technology identifies MLKL polymerization-induced LMP as a promising target for innovative medications. Advancing Precision Medicine: Isolated lysosomes with activated p-MLKL and MLKL offer resources for personalized treatments. Early Disease Detection: Live-cell imaging enables timely identification of necroptosis-related...
Published: 5/11/2026
|
Updated: 8/31/2023
|
Inventor(s):
Preston Perez
,
Zhigao Wang
,
Shuzhen Liu
Keywords(s):
Cancer Treatment
Category(s):
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Therapeutics
Novel Peptidomimetics for the treatment of Doxorubicin-Induced Cardiomyopathy
Advantages: Compounds (peptidomimetic inhibitors) that prevent Doxorubicin-induced cardiomyopathy (DIC) that can occur with cancer chemotherapy Peptide therapeutics have high specificity, potency, and low toxicity when compared to traditional small molecule drugs Potentially enabling cancer patients to receive DOX treatment without compromising...
Published: 5/11/2026
|
Updated: 8/2/2023
|
Inventor(s):
Jianfeng Cai
,
Zhigao Wang
,
Yizhan Zhai
,
Xue Zhao
,
Xueling Ma
,
Ken Chen
Keywords(s):
Biotechnology
,
Cancer Diagnostics
,
Cancer Treatment
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Oncology