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Search Results - zhigao+wang
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Blocking Necroptosis in Kidney Transplantation: PPP1R3G Targeting to Improve Graft Function and Survival
Advantages Novel Mechanism: Identifies PPP1R3G as a previously unexplored regulatory node in necroptosis during kidney transplantation. Demonstrated Preclinical Efficacy: In animal models, inhibition of PPP1R3G signaling resulted in a ~65% reduction in plasma creatinine and a ~55% improvement in glomerular filtration rate (GFR). Peptidomimetic...
Published: 1/13/2026
|
Inventor(s):
Lei Wang
,
Zhigao Wang
,
Jianfeng Cai
Keywords(s):
Organ Transplantation
,
Renal / Kidney
Category(s):
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Chemistry
,
Technology Classifications > Medical > Therapeutics
MLKL Polymerization-Induced Lysosome Membrane Permeabilization Drives Necroptotic Cell Death
Advantages: Novel Drug Targets: Technology identifies MLKL polymerization-induced LMP as a promising target for innovative medications. Advancing Precision Medicine: Isolated lysosomes with activated p-MLKL and MLKL offer resources for personalized treatments. Early Disease Detection: Live-cell imaging enables timely identification of necroptosis-related...
Published: 10/14/2025
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Inventor(s):
Preston Perez
,
Zhigao Wang
,
Shuzhen Liu
Keywords(s):
Cancer Treatment
Category(s):
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Therapeutics
Novel Peptidomimetics for the treatment of Doxorubicin-Induced Cardiomyopathy
Advantages: Compounds (peptidomimetic inhibitors) that prevent Doxorubicin-induced cardiomyopathy (DIC) that can occur with cancer chemotherapy Peptide therapeutics have high specificity, potency, and low toxicity when compared to traditional small molecule drugs Potentially enabling cancer patients to receive DOX treatment without compromising...
Published: 12/4/2025
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Inventor(s):
Jianfeng Cai
,
Zhigao Wang
,
Yizhan Zhai
,
Xue Zhao
,
Xueling Ma
,
Ken Chen
Keywords(s):
Biotechnology
,
Cancer Diagnostics
,
Cancer Treatment
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Oncology