Search Results - skin

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Methods and Compositions for Treating Melanoma (UCLA Case No. 2021-324)
The Graeber Laboratory at UCLA discovered a novel mechanism for treating melanoma using ferroptosis, a type of programmed cell death, that shows promise against therapy resistance. BACKGROUND: Melanoma is a highly aggressive skin cancer that spreads throughout the body and can be fatal if left untreated. Therapies for melanoma range from immunotherapy...
Published: 7/10/2024   |   Inventor(s): Thomas Graeber
Keywords(s): Cancer, ferroptosis, Immunotherapy, MAPK signaling, Melanoma, Oncology, Skin, tumor resistance
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
A Novel Carbohydrate Antibody to GalNac1-3Gal and Its Application for Cancer Diagnostic and Prognosis
Abstract: Cervical cancer is one of the most common cancers among women worldwide. Currently, physical descriptors such as tumor size and depth are the primary factors used for deciding the course of treatment. Despite significant efforts to identify prognostic biochemical markers or therapeutic targets to improve diagnosis and treatment, none have...
Published: 4/8/2024   |   Inventor(s): Jeffrey Gildersleeve, Zhitao Li, Qian Li, Miriam Anver, Donna Butcher
Keywords(s): ANTIBODY, CERVICAL, GaLNAc1-3Gal, Gildersleeve, Immunohistochemical staining, Larynx, Prognostic marker, SKIN, Squamous Cell
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
Staphylococcus Epidermidis Isolates from Human Skin Samples for Use as Clinical Molecular Markers
This technology includes a catalog of commensal and pathogenic staphylococci from human skin for utilization as clinical molecular markers of skin conditions and infections. The study of microbial diversity of human skin in both healthy and disease states is important to develop tools to track infections, outbreaks, and multi-drug resistant organisms,...
Published: 7/30/2024   |   Inventor(s): Lilia Mijares, Heidi Kong, Julia ("Julie") Segre
Keywords(s): Epidermidis, Human, ISOLATES, SAMPLES, SKIN, Staphylococcus, VJXXXX, WBXXXX, WIXXXX, XCXXXX
Category(s): TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials
Pre-Biotic Formulation of Topical Chemicals for Use on Human Skin
Atopic dermatitis (AD) is a common, recurrent, chronic inflammatory skin disease that is a cause of considerable economic and social burden. It is one of the most prevalent skin disorders, affecting ~25% of children in developed and developing countries and is expected to continue to escalate. This increased rate of incidence has changed the focus of...
Published: 7/25/2024   |   Inventor(s): Carlo Castillo, Ian Myles
Keywords(s): CHEMICALS, FORMULATION, Human, Pre-biotic, SKIN, TOPICAL
Category(s): Collaboration Sought > Collaboration
Method of Producing Immortalized Primary Human Keratinocytes for HPV Investigation, Testing of Therapeutics, and Skin Graft Generation
One of the major limitations of using cultured keratinocytes for research studies is that primary keratinocytes senesce after a few passages. Keratinocytes from specific anatomical sites are also difficult to culture. Scientists at the NIH have demonstrated that primary keratinocytes, from several anatomical sites, when treated with a small-molecule...
Published: 7/25/2024   |   Inventor(s): Sandra Chapman, Jonathan Vogel, Atsushi Terunuma, Alison McBride
Keywords(s): AC4XXX, ACXXXX, AXXXXX, CC3XXX, CCXXXX, Complete, CXXXXX, DDXXXX, DXXXXX, EXTENDED, grafting, Human, IB2BXX, IB2XXX, IBXXXX, inhibitor, IXXXXX, KERATINOCYTES, Keratinocytes., Life-cycle, LONG-TERM, Maintenance, Papillomaviruses., Patent Category - Biotechnology, Persistence, Primary, PROLIFERATIVE, REPLICATION, ROCK, RXXXXX, SKIN, STATE, Studies., Sustain, Y-27632
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Therapeutics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Dermatology, TherapeuticArea > Infectious Disease
2023-001 Skinprofiler: Low-Cost 3D Scanner for Skin Health Monitoring With Mobile Devices
Summary: UCLA researchers in the Electrical and Computer Engineering Department have developed SkinProfiler, an end-to-end skin profiling system that reconstructs and keeps track of 3D geometries of skin lesions and moles for long-term out-of-clinic skin health monitoring. Background: Skin cancers are among the most common types of cancer. In particular,...
Published: 7/19/2023   |   Inventor(s): Yang Zhang
Keywords(s): Cancer, Digital Health, Imaging, Melanoma, Mobile Phone, Skin, Smartphone
Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Software & Algorithms > Digital Health, Software & Algorithms > Artificial Intelligence & Machine Learning, Medical Devices, Medical Devices > Medical Imaging
2021-344 Biopsy-Free In Vivo Virtual Histology of Skin Using Deep Learning
Summary: UCLA researchers in the Departments of Electrical and Computer Engineering & Bioengineering have developed a non-invasive, biopsy-free technique for in vivo virtual histology of skin cancer using deep learning. Background: Tissue biopsies have often been used to diagnose skin cancers in patients. These procedures are generally cumbersome...
Published: 7/19/2023   |   Inventor(s): Aydogan Ozcan, Jingxi Li, Yair Rivenson, Xiaoran Zhang, Philip Scumpia, Jason Garfinkel, Gennady Rubinstein
Keywords(s): Artificial Intelligence, Biopsy, Cancer, Confocal Microscopy, Diagnostic Test, Histology, Image Resolution, Invasiveness Of Surgical Procedures, Melanoma, Optics, Skin, Software, Tissue (Biology), Tumor
Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Electrical > Imaging, Medical Devices > Medical Imaging, Optics & Photonics
Wearable Light Sensors Based on Unique Features of a Natural Biochrome
Wearable Light Sensors Based on Unique Features of a Natural Biochrome A novel, low cost, wearable device for measurement of sun exposure Background Exposure to sunlight’s harsh radiation has proven to be detrimental to our health. Ultraviolet (UV)-rays, infrared (IR) and to a lesser degree, visible light, all contribute to skin damage. Thus,...
Published: 9/10/2024   |   Inventor(s): Daniel Wilson, Leila Deravi
Keywords(s): Radiation detector, Sensor, Skin, Solar, Sterilization, Wearable
Category(s): -Chemistry, -Cosmetic, -Energy Technology, -Equipment, -Health, -Materials, -Sustainability / Renewable Tech, -Sensors, Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials, Technology Classifications > 2. Physical Science > Environmental/Clean tech, Technology Classifications > 1. Life Science > Green Chemistry, Technology Classifications > 1. Life Science > Medical Devices, Technology Classifications > 1. Life Science, Chemistry
Accelerated Wound Healing and Wrinkle Reduction
Project ID: D2006-10Background: Wound healing is the body's natural process of regenerating dermal and epidermal tissue. When an individual is wounded, a set of complex biochemical events takes place in a closely orchestrated cascade to repair the damage. Wound healing is generally considered to be a process occurring in three phases; inflammation,...
Published: 5/9/2024   |   Inventor(s): Joseph Shapiro, Zi-Jian Xie
Keywords(s): Cardiotonic steroid, Collagen, Na pump, Skin, Wound healing
Category(s): Wound Healing, Animal Health
Topical Treatment for Raynaud’s Phenomenon Targets Cold Receptor
Project ID: D2015-43IP Status: PCT Patent application Invention Description and Novelty: Systemic sclerosis (also known as scleroderma, SSc) is an autoimmune connective tissue disease that is characterized by the presence of Raynaud’s phenomenon (RP) that manifests by repeated episodes of vasospasm of the distal arteries...
Published: 6/18/2024   |   Inventor(s): Bashar Kahaleh, Sai HS Boddu, Nezam Altorok, Vivek Nagaraja
Keywords(s): Autoimmune, Raynaud's, Schlerosis, Skin, Topical, Treatment
Category(s): Inflammation & Immunity