Search Results - composition

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Novel VAR2CSA Immunogens and Methods of Use Thereof
The invention provides immunogen polypeptides comprising fragments of VAR2CSA protein expressed by P. falciparum as potential second-generation placental malaria vaccine candidates. VAR2CSA is the leading antigen target for a placental malaria vaccine, where associated antibody titers are correlated with protection. Aspects of the inventive immunogen...
Published: 10/28/2024   |   Inventor(s): Rui Ma, Niraj Tolia
Keywords(s): Against, CANCER, COMPOSITION, COMPRISING, Diagnostics, IMMUNOGENS, Malaria, Matter, Placental, PROTECT, proteins, That, therapeutics, Used
Category(s): Collaboration Sought > Collaboration
Eeyarestatins: Novel Deubiquitination Inhibitors for the Treatment of Drug-Resistant Cancers
The ubiquitin-proteasome system has recently been recognized to play a central role in tumor biology. Bortezomib, an inhibitor of the chymotrypsin-like activity of the proteasome, has clinical activity in a variety of hematologic malignancies and is FDA approved for use in Multiple Myeloma and Mantle Cell Lymphoma. The present invention for the first...
Published: 10/28/2024   |   Inventor(s): Helena Mora-Jensen, Qiuyan Wang, Yihong Ye, Adrian Wiestner
Keywords(s): Active, Against, BBXXXX, Bortezomib, CANCER, CB5EXX, CB5XXX, CBXXXX, Cells, Chronic lymphocytic leukemia, COMPOSITION, CXXXXX, DB4AXX, DB4XXX, DBXXXX, Deubiquination, DXXXXX, Eeyarestatin, Hematologic, Highly, HIV AIDS - Therapeutics, Including, inhibitor, lymphoma, Mantle cell lymphoma, MULTIPLE MYELOMA, Proteasome, RESISTANT, That, tumor
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology
Mouse Model for Study of Diabetic Nephropathy and Role of Soluble Epoxide Hydrolase
Diabetic nephropathy (DN) is the leading cause of renal failure and is characterized by proteinuria that progresses to renal inflammation and decline in the glornerular filtration barrier (GFB). Podocytes are specialized epithelia cells in the glomerular capsule that have a role in filtration of blood and maintaining the integrity of the GFB; dysfunction...
Published: 10/28/2024   |   Inventor(s): Darryl Zeldin
Keywords(s): COMPOSITION, Methods, Nephropathy, TREATING, VFXXXX, VPXXXX, WIXXXX, WJXXXX, WKXXXX, XEXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Research Materials, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology
ApoA-1 Mimetic Peptides Promoting Lipid Efflux from Cells for Treatment of Vascular Disorders
This invention involves ApoA-1 mimetic peptides with multiple amphipathic alpha-helical domains that promote lipid efflux from cells and are useful in the treatment and prevention of dyslipidemic, inflammatory and vascular disorders. IND-enabling studies for one of the peptides, named Fx-5A, are completed in preparation for an IND filing at the FDA,...
Published: 10/28/2024   |   Inventor(s): Edward Neufeld, Fairwell Thomas, H. Bryan Brewer, Stephen Demosky, John Stonik, Marcelo Amar, Alan Remaley
Keywords(s): (4)r syndrome, 3-@hydroxyacyl-coa dehydrogenase deficiency, AMPHIPATHIC, assay, Atherosclerosis., C syndrome, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, COMPOSITION, G syndrome, HAD deficiency, HELICAL, HIS deficiency, Histidinemia, Hyperlipoproteinemia, Hypertelorism with esophageal abnormality and hypospadias, IA1XXX, IAXXXX, IXXXXX, Listed LPM Nguyen-Antczak as of 4/15/2015, Multi-domain, N syndrome, Patent Category - Biotechnology, Peptides, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R(6) syndrome, R(7) syndrome, Syndrome X, System, treatment, UA1XXX, VDXXXX, VHXXXX, W syndrome, W syndrome; Syndrome W, WJXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics